A5012305234- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Visual perception and processing mechanisms
- Transcranial Magnetic Stimulation Studies
- Cardiac Arrhythmias and Treatments
- Neural dynamics and brain function
- Cardiac electrophysiology and arrhythmias
- Neural and Behavioral Psychology Studies
- Cardiac Imaging and Diagnostics
- Neuroscience and Neural Engineering
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vestibular and auditory disorders
- Face Recognition and Perception
- Cerebrovascular and Carotid Artery Diseases
- Pulmonary Hypertension Research and Treatments
- Pancreatitis Pathology and Treatment
- Neurological and metabolic disorders
- Heart Failure Treatment and Management
- Pain Management and Treatment
- Chronic Kidney Disease and Diabetes
- Spatial Neglect and Hemispheric Dysfunction
- Neurological Complications and Syndromes
- Advanced Memory and Neural Computing
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
Charité - Universitätsmedizin Berlin
2010-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Berlin Heart (Germany)
2022
Humboldt State University
2008
Understanding processes performed by an intact visual cortex as the basis for developing methods that enhance or restore perception is of great interest to both researchers and medical practitioners. Here, we explore whether contrast sensitivity, a main function primary (V1), can be improved in healthy subjects repetitive, noninvasive anodal transcranial direct current stimulation (tDCS). Contrast was measured via threshold perimetry directly before after intervention (tDCS sham stimulation)...
ABSTRACT Aims Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health‐related quality life (HRQOL) in the general population, but data on HRQOL stroke patients with newly diagnosed are sparse. Methods Post hoc analysis prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity associated after or transient attack (TIA). was...
Background Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection. Methods and Results The investigator‐initiated, prospective, open, multicenter MonDAFIS (Impact of Standardized Monitoring Detection Atrial Fibrillation in Ischemic Stroke) study randomized 3465 patients with acute ischemic stroke without known AF 1:1 to usual diagnostic procedures detection or additive Holter monitoring hospital up 7 days, analyzed core...
Purpose: TDCS can increase excitability in the visual cortex. It is a matter of current debate if tDCS improve performance. Promising parameters to measure detection sensitivity may be those signal theory ( = SDT), as it
Background In patients with acute ischemic stroke, little is known regarding the frequency of abnormal ECG findings other than atrial fibrillation and their association cardiovascular outcomes. We aim to analyze type findings, subsequent changes in medical treatment, outcomes stroke. Methods Results investigator-initiated multicenter MonDAFIS (impact standardized monitoring for detection stroke) study, 3465 stroke or transient attack without were randomized 1:1 receive Holter-ECG up 7 days...
Background Oral anticoagulation (OAC) is key in stroke prevention patients with atrial fibrillation (AF) but there uncertainty regarding the optimal timing of OAC (re)initiation after stroke, as recent large randomised controlled trials have methodological weaknesses and excluded on therapeutic at onset well started a vitamin K antagonist stroke. The ‘1–3–6–12 days rule’, based expert consensus referring to severity, was used clinical practice initiate acute ischaemic or transient attack...
We aimed to analyze prevalence and predictors of NOAC off-label under-dosing in AF patients before after the index stroke.
To what extent are the left and right visual hemifields spatially coded in dorsal frontoparietal attention network? In many experiments with neglect patients, hemisphere shows a contralateral hemifield preference, whereas represents both hemifields. This pattern of spatial coding is often used to explain right-hemispheric dominance lesions causing hemispatial neglect. However, pathophysiological mechanisms controversial because recent on healthy subjects produced conflicting results...
Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of stroke lesions can used predict AF in patients without known at baseline. Lesion quantification on brain MRI was performed selected from intervention arm Impact standardized MONitoring for Detection Fibrillation Ischemic Stroke (MonDAFIS) study, which included with or TIA prior AF. Multiple morphologic...
Abstract Heart failure (HF) is associated with poor outcome after stroke, but data from large prospective trials are sparse. We assessed the impact of HF on clinical endpoints in patients hospitalized acute ischemic stroke or transient attack (TIA) enrolled prospective, multicenter Systematic Monitoring for Detection Atrial Fibrillation Patients Acute Ischemic Stroke (MonDAFIS) trial. was defined as left ventricular ejection fraction (LVEF) < 55% a history admission. The composite...
Abstract Background About 25% of all ischaemic strokes are related to cardio-embolism, most often due atrial fibrillation (AF). Little is known about the extent and standardization routine cardiac diagnostic work-up at certified stroke-units in Germany. Methods The MonDAFIS study included non-AF patients with acute stroke or transient attack (TIA) 38 Here, we analysed disregarded study-related Holter-ECG monitoring. We compared duration stroke-unit stay, number 24-h Holter-ECGs,...
How do we find a target object in cluttered visual scene? Targets carrying unique salient features can be found parallel without directing attention, whereas targets defined by feature conjunctions or non-salient need to scrutinized serial attentional process order identified. In this article, review series of experiments which used fMRI probe the neural basis active search human brain. all experiments, compared signal between difficult and an easy (each performed eye movements) isolate...
Introduction: In the primary visual cortex, transcranial direct current stimulation (tDCS) is able to induce upward and downward excitability shifts of cortex measured by an altered TMS phosphene threshold in V1 (Antal et al. 2006). Anodal tDCS enhances excitability, while cathodal diminishes it 2003). present study we investigated which degree can changes psychophysical performance. Therefore, detection sensitivity was examined a discrimination task measuring d' (=z-transformed hit rate...
Introduction: During visual search for a target object within cluttered scene, 'frontoparietal network' is engaged. The core components of the frontoparietal network are frontal eye fields (FEF) and several sub-regions intraparietal sulcus (IPS) (1,2). It still unclear if activation in during reflects spatial selection process (3,4). aim this fMRI-study was to analyze which degree population activity these areas human brain attention other operations involved visuo-motor integration search.
Impaired kidney function is associated with an increased risk of vascular events in acute stroke patients, when assessed by single measurements estimated glomerular filtration rate (eGFR). It unknown whether repeated provide additional information for prediction.The MonDAFIS (Systematic Monitoring Detection Atrial Fibrillation Patients Acute Ischemic Stroke) study randomly assigned 3465 ischemic patients to either standard procedures or additive Holter electrocardiogram. Baseline eGFR...
Introduction: Anodal transcranial direct current stimulation (tDCS) can induce upward excitability shifts in the primary visual cortex, e.g. as measured by an altered TMS phosphene threshold V1 (Nitsche et al. 2008). However effect of a singular is limited to 10–20 minutes (Antal 2006). In motor system it was demonstrated that anodal tDCS over multiple days facilitated skill acquisition through consolidation. The measure remained greater for even after three months (Reis 2009). analogy we...
(1) To assess the accuracy of a standard operating procedure (SOP) regarding utilization atrial fibrillation (AF) alarms in everyday clinical practice, and (2) to evaluate performance automated continuous surveillance for hospitalized acute stroke patients.Retrospective cohort study.Two units from two tertiary care hospitals Berlin, Germany.We identified 635 patients with ischemic diagnosis time period between 01. January 30. September 2021 which 176 had recorded AF during monitoring. Of...