A5046690120- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- RNA regulation and disease
- RNA Research and Splicing
- Sleep and Wakefulness Research
- Muscle activation and electromyography studies
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Botulinum Toxin and Related Neurological Disorders
- Vestibular and auditory disorders
- Meningioma and schwannoma management
Hadassah Academic College
2016-2025
Hebrew University of Jerusalem
1995-2025
Hadassah Medical Center
2016-2025
Hadassah
2009-2024
Herzog Hospital
2007-2019
Sorbonne Université
2017
Hôpital Necker-Enfants Malades
2017
Centre for Sight
2015
University Medical Center
2010
Bar-Ilan University
2008
The significance of oscillations that characterize the subthalamic nucleus in Parkinson's disease is still under debate. Here, we analysed spectral and spatial characteristics 314 microelectrode trajectories from 128 patients undergoing deep brain stimulation surgery for disease. We correlated pathophysiology with outcome surgery, as evaluated by third section Unified Disease Rating Scale (motor score), which was subdivided into tremor, rigidity, limb-bradykinesia axial-bradykinesia...
The emergence of oscillations and synchrony among neurons the basal ganglia is a well-known characteristic Parkinson's disease. In this study we used intra-operative microelectrode recording to investigate interrelationship between these two phenomena in subthalamic nucleus (STN) 39 human disease patients undergoing deep brain stimulation surgery. From recorded neuronal traces both spike trains their background activity were extracted, spectral characteristics evaluated. We have as marker...
The continuously prolonged human lifespan is accompanied by increase in neurodegenerative diseases incidence, calling for the development of inexpensive blood-based diagnostics. Analyzing blood cell transcripts RNA-Seq a robust means to identify novel biomarkers that rapidly becomes commonplace. However, there lack tools discover exons, junctions and splicing events precisely sensitively assess differential through data analysis across platforms. Here, we present new comprehensive...
MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes. However, the detailed profile miRNA expression in Parkinson's disease, second most common neurodegenerative disease worldwide and first motor disorder has not been charted yet. Here, we report comprehensive profiling by next-generation small-RNA sequencing, combined with targets inspection splice-junction exon arrays interrogating leukocyte RNA patients before after deep brain stimulation (DBS)...
The striatum and the subthalamic nucleus (STN) constitute input stage of basal ganglia (BG) network together innervate BG downstream structures using GABA glutamate, respectively. Comparison neuronal activity in reveals that subthalamic, not striatal, fluctuations correlate with modulations increase/decrease discharge balance neurons during temporal discounting classical condition task. After induction parkinsonism 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), abnormal low beta (8-15...
ABSTRACT Background: The efficacy of deep brain stimulation (DBS) ‐ primarily the subthalamic nucleus (STN) for advanced Parkinson's disease (PD) is commonly attributed to suppression pathological synchronous β oscillations along cortico‐thalamo‐basal ganglia network. Conventional continuous high‐frequency DBS indiscriminately influences and normal neural activity. protocol would therefore be more effective if was only applied when necessary (closed‐loop adaptive DBS). Objectives Methods:...
Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients animal models suggest that beta-power increases with dopamine depletion. However, exact relationship between power, frequency tone remains unclear. We recorded neural ganglia of healthy non-human primates while acutely chronically up- down-modulating levels. assessed changes beta oscillations following acute chronic tone. Here we show...
Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functional convergence among genes, hinting at shared pathomechanism. However, neural dynamics supporting this remain largely unexplored. Methods Herein, we analyzed microelectrode recordings acquired during pallidal deep brain stimulation surgery 31 patients AOPEP , GNAL KMT2B PANK2 PLA2G6 SGCE THAP1...
Abstract Positive therapeutic response without adverse side effects to subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson's disease (PD) depends a large extent on electrode location within the STN. The sensorimotor region of STN (seemingly preferred lies dorsolaterally, in also marked by distinct beta (13–30 Hz) oscillations parkinsonian state. In this study, we present real‐time method accurately demarcate subterritories during surgery, based microelectrode recordings (MERs)...
The basal ganglia (BG) have been hypothesized to implement a reinforcement learning algorithm. However, it is not clear how information processed along this network, thus enabling perform its functional role. Here we present three different encoding schemes of visual cues associated with rewarding, neutral, and aversive outcomes by BG neuronal populations. We studied the response profile dynamical behavior two populations projection neurons [striatal medium spiny (MSNs), in external segment...
Implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN) for treatment Parkinson disease is often performed using microelectrode recording (MER) STN population spike activity. The extent to which sedative drugs interfere with MER unknown. We recorded activity neurons during propofol sedation and examined its effect on neuronal activity.The procedure was DBS surgery disease. administered (50 μg/kg/min) at a constant electrode location until stable achieved....
ABSTRACT Background Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery Parkinson's disease. Usually, demarcation STN is performed manually by a neurophysiologist. The exact detection difficult, especially detecting transition between and substantia nigra pars reticulata. Consequently, may be inaccurate, leading to suboptimal location DBS lead inadequate clinical...
Abstract Obsessive-compulsive disorder (OCD) is a common and serious psychiatric disorder. Although subthalamic nucleus deep brain stimulation (DBS) has been studied as treatment for OCD patients the underlying mechanism of this optimal method are unknown. To study neural basis DBS in we used novel, implantable system with long-term local field potential sensing capability. We focus our analysis on two who experienced severe treatment-resistant symptoms were implanted systems. them year at...
Abstract Deep brain stimulation (DBS) has been proposed for severe, chronic, treatment-refractory obsessive-compulsive disorder (OCD) patients. Although serious adverse events can occur, only a few studies report on the safety profile of DBS psychiatric disorders. In prospective, open-label, interventional multi-center study, we examined and efficacy electrical in 30 patients with electrodes bilaterally implanted anterior limb internal capsule. Safety, efficacy, functionality assessments...
Emotional processing is lateralized to the non-dominant brain hemisphere. However, there no clear spatial model for lateralization of emotional domains in basal ganglia. The subthalamic nucleus (STN), an input structure ganglia network, plays a major role pathophysiology Parkinson's disease (PD). This probably not limited only motor deficits PD, but may also span and cognitive commonly observed PD patients. Beta oscillations (12-30 Hz), electrophysiological signature are restricted...
Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic represent locally generated neuronal subthreshold activity or volume conductance of organized in cortex. This study aimed at understanding physiological origin determining most accurate method for recording them. We compared different methods recordings human nucleus: spikes (300-9,000 Hz) (3-100 recorded by monopolar micro-...
To determine whether the time between onset of anisocoria and surgery for hematoma evacuation in head-injured patient is a useful prognostic variable outcome comatose with an acute epidural hematoma.Prospective.Twenty-one patients traumatic admission Glasgow Coma Scale score less than 8 were analyzed.Anisocoria was present 14 (67%) patients. Mortality rate three times higher this group without anisocoria; however, difference not statistically significant (p = 0.21, Fisher's exact test). None...
Abstract The subthalamic nucleus (STN) is a major target for treatment of advanced Parkinson's disease patients undergoing deep brain stimulation surgery. Microelectrode recording (MER) used in many cases to identify the nucleus. A real‐time procedure identifying entry and exit points STN would improve outcome this targeting procedure. We normalized root mean square (NRMS) short (5 seconds) MER sampled signal estimated anatomical distance (EDT) as basis Electrode tip location was defined...