A5077924225- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Cephalopods and Marine Biology
- Robot Manipulation and Learning
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Tactile and Sensory Interactions
Hebrew University of Jerusalem
2008-2024
Hadassah Medical Center
2011-2024
Weizmann Institute of Science
2020-2022
Midbrain dopaminergic neurons (DANs) typically increase their discharge rate in response to appetitive predictive cues and outcomes, whereas striatal cholinergic tonically active interneurons (TANs) decrease rate. This may indicate that the activity of TANs DANs is negatively correlated can broaden basal ganglia reinforcement teaching signal, for instance by encoding worse than predicted events. We studied 106 180 two monkeys recorded during performance a classical conditioning task with...
We studied correlated firing between motor thalamic and cortical cells in monkeys performing a delayed-response reaching task. Simultaneous recording of thalamocortical activity revealed that around movement onset, were positively with cell the primary cortex but negatively premotor cortex. The differences correlation contrasted average neural responses, which similar all three areas. Neuronal correlations reveal functional cooperation opposition thalamus distinct areas specific roles...
N-methyl-d-aspartate (NMDA) antagonists are widely used in anesthesia, pain management, and schizophrenia animal model studies, recently as potential antidepressants. However, the mechanisms underlying their anesthetic, psychotic, cognitive, emotional effects still elusive. The basal ganglia (BG) integrate input from different cortical domains through dopamine-modulated connections to achieve optimal behavior control. NMDA have been shown induce gamma oscillations human EEG recordings rodent...
Octopus arms, as well other muscular hydrostats, are characterized by a very large number of degrees freedom and rich motion repertoire. Over the years, several attempts have been made to elucidate interplay between biomechanics these organs their control systems. Recent developments in electrophysiological recordings from both arms brains behaving octopuses mark significant progress this direction. The next stage is relating octopus arm movements, which requires an accurate reliable method...
Current anatomical models of the cortico-basal ganglia (BG) network predict reciprocal discharge patterns between external and internal segments globus pallidus (GPe GPi, respectively), as well cortical driving BG activity. However, physiological studies revealing similarity in transient responses GPe GPi neurons cast doubts on these predictions. Here, we studied properties GPe, primary motor cortex two monkeys distinct states: when eyes are open versus they closed. Both pallidal populations...
Abstract Focal cortical epilepsies are frequently refractory to available anticonvulsant drug therapies. One key factor contributing this state is the limited availability of animal models that allow reliably study focal seizures and how they recruit surrounding brain areas in vivo. In study, we selectively expressed inhibitory chemogenetic receptor, hM4D, GABAergic neurons using viral gene transfer. silencing Clozapine-N-Oxide (CNO) demonstrated reliable induction local epileptiform events...
Local field potentials (LFP) in the basal ganglia (BG) have attracted considerable research and clinical interest. The genesis of these signals has been a topic extensive discourse, focusing on whether they are manifestation local synaptic activity or result from propagation electrical through tissue, as described by Maxwell equations (volume conduction). To investigate this, we conducted simultaneous recordings LFPs two cortical areas— dorsolateral prefrontal cortex (DLPFC) primary motor...
Abstract Focal cortical epilepsies are frequently refractory to available anticonvulsant drug therapies. One key factor contributing this state is the limited availability of animal models that allow reliably study focal seizures and how they recruit surrounding brain areas in-vivo . In study, we selectively expressed inhibitory chemogenetic receptor, hM4D, in GABAergic neurons using viral gene transfer. Following silencing by administration Clozapine-N-Oxide (CNO), demonstrated reliable...
Local Field potential (LFP) in the basal ganglia (BG) nuclei brain have attracted much research and clinical interest. However, origin of this signal is still under debate throughout last decades. The question whether it a local subthreshold phenomenon, synaptic input to neurons or flow electrical signals merged as volume conduction which are generated from simultaneous firing cerebral cortex obeys Maxwell equations. In study, we recorded monkey simultaneously LFP's cortex, frontal lobe...