A5024112851- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Amyotrophic Lateral Sclerosis Research
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Functional Brain Connectivity Studies
- Neurogenetic and Muscular Disorders Research
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Hereditary Neurological Disorders
- Pain Management and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Migraine and Headache Studies
- Muscle activation and electromyography studies
- Neurology and Historical Studies
- Trigeminal Neuralgia and Treatments
- Spinal Cord Injury Research
- Cardiovascular Health and Disease Prevention
- Neural and Behavioral Psychology Studies
University of Pisa
2014-2023
Don Carlo Gnocchi Foundation
2021-2023
Neuroscience Institute
2013-2022
Ospedale Cisanello
2011-2021
University of Milan
2019
Azienda Ospedaliera Universitaria Pisana
2013-2019
Northwestern University
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
University of Minho
2019
Angelman syndrome (AS) results from lack of genetic contribution maternal chromosome 15q11-13. This region encompasses three GABAA receptor subunit genes (beta3, alpha5, and gamma3). The characteristic phenotype AS is severe mental retardation, ataxic gait, tremulousness, jerky movements. We studied the movement disorder in 11 patients, aged 3 to 28 years. Two patients had paternal uniparental disomy for 15, 8 a >3 Mb deletion, 1 microdeletion involving loci D15S10, D15S113, GABRB3. All...
This study aimed to assess the effects of thoracic anodal and cathodal transcutaneous spinal direct current stimulation (tsDCS) on upper lower limb corticospinal excitability. Although there have been studies assessing how tsDCS influences ascending tract reflexes, none has assessed this technique over corticomotor neuronal connections. In 14 healthy subjects we recorded motor evoked potentials (MEPs) elicited by transcranial magnetic (TMS) from abductor hallucis (AH) hand digiti minimi...
SummaryIt is known that vision may be altered in optic neuritis. Our aim was to establish whether chromatic and achromatic are differentially impaired using stimuli designed favour the activity of either magnocellular or parvocellular stream visual pathway. Fourteen patients with a past history unilateral neuritis course multiple sclerosis 10 age-matched control subjects were included study. Patients had relatively good acuity affected eyes no gross colour deficits (Ishihara). Stimuli...
Laser-evoked potentials (LEPs) are brain responses to laser radiant heat pulses and reflect the activation of Adelta nociceptors. LEPs date reference standard technique for studying nociceptive pathway function in patients with neuropathic pain. To find out whether also provide a useful neurophysiological tool assessing antinociceptive drug efficacy, this double-blind placebo-controlled study we measured changes induced by analgesic tramadol on 12 healthy subjects. We found that decreased...
Purpose: The cerebellum is involved in a wide number of integrative functions, but its role pain experience and the nociceptive information processing poorly understood. In healthy volunteers we evaluated effects transcranial cerebellar direct current stimulation (tcDCS) by studyin g changes perceptive threshold, intensity at given intensities (VAS:0-10) laser evoked potentials (LEPs) variables (N1 N2/P2 amplitudes latencies). Methods: Fifteen subjects were studied before after anodal,...
Summary Objective Juvenile myoclonic epilepsy ( JME ) is a young‐onset electroclinical syndrome, characterized by myoclonic, generalized tonic–clonic, and possibly typical absence seizures. Interictal electroencephalography EEG) displays 3–6 Hz spike/polyspike wave pattern. Photosensitivity common. Our aim was to explore the blood oxygen level–dependent BOLD) response evoked highly provocative photic stimulus in cohort of people with compared group nonphotosensitive healthy controls,...
Event-Related Potentials (ERPs) occurring independently from any stimulus are purely endogenous (emitted potentials) and their neural generators can be unequivocally linked with cognitive processes. In the present study, subjects performed two similar visual counting tasks: a standard two-stimulus oddball, an omitted-target oddball task, characterized by physical absence of target stimulus. Our investigation aimed at localizing sources scalp-recorded endogenous/emitted ERPs. To optimize...
Cerebral microembolism has often been documented by transcranial Doppler imaging during carotid angioplasty and stenting. However, few data are available about its characteristics the 2 different kinds of procedure.To compare incidence microemboli occurring alone with that stenting in phases procedures to relate it periprocedural cerebrovascular complications.Thirty-eight patients underwent 41 (15 26 stenting) for symptomatic stenoses 70% or more. Transcranial monitoring was performed detect...
Summary In Parkinson’s disease (PD), the luminance pattern electroretinogram (PERG) is reported to be abnormal, indicating dysfunction of retinal ganglion cells (RGCs). To determine vulnerability different subpopulations RGCs in PD patients, authors recorded PERG stimuli chromatic (red-green [R-G] and blue-yellow [B-Y]) achromatic (yellow-black [Y-Bk]) contrast, known emphasize contribution parvocellular, koniocellular, magnocellular RGCs, respectively. Subjects were early patients (n = 12;...
Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients mild or moderate cerebellar deficit age sex-matched healthy controls. SCA2 showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss GM the vermis hemispheres sparing lobules I,II, Crus II,VII, X, WM peridentate region,...