Giuliana Galassi
A5056379297- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Long-Term Effects of COVID-19
- Parkinson's Disease and Spinal Disorders
- Autoimmune Neurological Disorders and Treatments
- Peripheral Nerve Disorders
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Herpesvirus Infections and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Cerebral Venous Sinus Thrombosis
- Inflammatory Myopathies and Dermatomyositis
- Botulinum Toxin and Related Neurological Disorders
- Mitochondrial Function and Pathology
- Intramuscular injections and effects
- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Plant-based Medicinal Research
- Muscle and Compartmental Disorders
- Multiple Sclerosis Research Studies
- Tracheal and airway disorders
University of Modena and Reggio Emilia
2016-2025
Erasmus MC
2019-2023
University of Michigan–Ann Arbor
2023
Aarhus University Hospital
2023
University of Milano-Bicocca
2022
Amsterdam University Medical Centers
2022
Lahey Medical Center
2022
Affiliated Hospital of Jining Medical University
2022
University of Amsterdam
2022
Amsterdam Neuroscience
2022
PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react peripheral-nerve antigens. We report on a patient peripheral an IgMk protein, in whom pathological and immunological studies indicated that antibody was directed against myelin, as shown by complement fixation immunoabsorption.Case ReportThe 45-year-old man admitted for evaluation of slowly progressive sensory-motor 11 years' duration. On examination there...
Guillain-Barré syndrome is a heterogeneous disorder regarding the clinical presentation, electrophysiological subtype and outcome. Previous single country reports indicate that may differ among regions, but no systematic comparative studies have been conducted. Comparative are required to identify factors determining disease susceptibility, variation prognosis, improve diagnostic criteria. The International Syndrome Outcome Study prospective, observational cohort study including all patients...
<h3>Objective</h3> To define the current treatment practice of Guillain-Barré syndrome (GBS). <h3>Methods</h3> The study was based on prospective observational data from first 1,300 patients included in International GBS Outcome Study. We described general, and for (1) severe forms (unable to walk independently), (2) no recovery after initial treatment, (3) treatment-related fluctuations, (4) mild (able (5) variant including Miller Fisher syndrome, taking patient characteristics hospital...
To investigate CSF findings in relation to clinical and electrodiagnostic subtypes, severity, outcome of Guillain-Barré syndrome (GBS) based on 1,500 patients the International GBS Outcome Study.
50%-60% of patients with ocular myasthenia gravis (OMG) progress to generalized (GMG) within two years. The aim our study was explore factors affecting prognosis OMG and test the predictive role several independent clinical variables.We reviewed a cohort 168 Caucasian followed from September 2000 January 2016. Several variables were considered as prognostic factors: gender, age onset, results on electrophysiological tests, presence level antibodies against acetylcholine receptors (AChR Abs),...
<h3>Background and Objectives</h3> The clinical course outcome of the Guillain-Barré syndrome (GBS) are diverse vary among regions. modified Erasmus GBS Outcome Score (mEGOS), developed with data from Dutch patients, is a model that predicts risk walking inability in patients GBS. study objective was to validate mEGOS International Study (IGOS) cohort improve its performance region specificity. <h3>Methods</h3> We used prospective first 1,500 included IGOS, aged ≥6 years unable walk...
Guillain-Barré syndrome (GBS) is a rapidly progressive, inflammatory polyradiculoneuropathy with heterogeneous presentation and pathogenesis. Diagnosis clinical electrophysiological, supportive features in cerebrospinal fluid. Respiratory insufficiency life-threatening manifestation occurring 20 to 30% of GBS patients associated poor functional outcome. Progressive weakness the respiratory muscles leading cause acute distress, failure hypoxemia hypercapnia. Bulbar may compromise airway...
Abstract Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside are thought to play a key role clinical diversity disease and can be helpful practice. Extensive research into associations individual anti-ganglioside antibody specificities has been performed. Recent highlighted glycolipid complexes, combinations may alter binding, as...
Abstract Two brothers and an unrelated man had serum creatine kinase values of 3000–8000 units when they were asymptomatic, there was no weakness on examination. EMG muscle biopsy showed changes indicative myopathy. Years later, all three developed that limited to the gastrocnemius. Because siblings affected, disorder can be regarded as a form muscular dystrophy. The distribution weakness, enzyme changes, histologic resembled autosomal recessive distal myopathy first described by Miyoshi...
Abstract Background and purpose Various electrodiagnostic criteria have been developed in Guillain–Barré syndrome (GBS). Their performance a broad representation of GBS patients has not evaluated. Motor conduction data from the International Outcome Study (IGOS) cohort were used to compare two widely criterion sets relate these diagnostic amyotrophic lateral sclerosis criteria. Methods From first 1500 IGOS, nerve studies 1137 (75.8%) available for current study. These classified according...
Two cases of sarcoid polyneuropathy were diagnosed by histological examination the nerve biopsy. The electrophysiological findings in both patients suggested a neuropathy axonal type, confirmed morphological study sural biopsy light microscopy and on teased-fiber preparations. granulomas multiple, especially case 2; they sparse epineurial perineurial spaces absent endoneurium, whose interstitial component contained cellular infiltrations scattered macrophages. Blood vessel changes constant...
To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part International GBS Outcome Study (IGOS).Prospectively clinical and EDx data were available 957 IGOS from 115 centers. Only first study was included current analysis.Median timing 7 days (interquartile range 4-11) symptom onset. Methodology varied between centers, countries regions. Reference values responding 103 centers derived locally 49%, publications 37% a...
We induced progressive conduction block in feline sciatic nerve by endoneurial injection of serum from 2 patients with demyelinating neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M protein. The was long-lasting (up to 4 days) affected about half the motor fibers. Control protein that did not react MAG produced a transient (<48 hours) average 25% Nerves sustained showed widespread demyelination many fibers, exceeding controls. findings support view chronic these is caused anti-MAG
Neuropathy associated with IgM monoclonal gammopathy (MGUS) represents distinctive clinical syndrome, characterized by male predominance, late age of onset, slow progression, predominantly sensory symptoms, deep loss, ataxia, minor motor impairment. More than 50% patients neuropathy-associated MGUS possess antibodies against myelin-associated glycoprotein (MAG). Purpose our study was to assess effects on disease progression demographic, and neurophysiological variables in large cohort...
To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated intravenous immunoglobulin (IVIg) or supportive care only.
Abstract Background and purpose The study aimed to identify predictors of respiratory failure leading mechanical ventilation (MV) tracheostomy in Guillain−Barré syndrome (GBS). Methods Two hundred thirty adult cases admitted the Neurology Unit Modena, Italy, between January 2000 December 2021 were studied. A cut‐off MV starting within 8 weeks from onset weakness was used. Univariable, multivariable logistic Cox regression analyses used determine which pre‐specified clinical diagnostic...