A5034122771- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Long-Term Effects of COVID-19
- Cancer Treatment and Pharmacology
- Peripheral Nerve Disorders
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Multiple Myeloma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- T-cell and B-cell Immunology
- Pain Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Neurological diseases and metabolism
- Whipple's Disease and Interleukins
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Takotsubo Cardiomyopathy and Associated Phenomena
- Melanoma and MAPK Pathways
Kindai University
2015-2025
Yamaguchi University
2023
Aarhus University Hospital
2022-2023
Japan Community Healthcare Organization
2023
Erasmus MC
2022
To investigate anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP).Sera from 50 consecutive CIDP patients diagnosed in our clinic, 32 with multiple sclerosis, 40 other neuropathies including 26 Guillain-Barré syndrome (GBS)/Fisher syndrome, and 30 healthy controls were measured for anti-NF antibodies by flow cytometry using HEK293 cell lines stably expressing human NF155 or NF186. Four additional anti-NF155 referred clinics enrolled...
<h3>Background and Objectives</h3> Infections play a key role in the development of Guillain-Barré syndrome (GBS) have been associated with specific clinical features disease severity. The variation GBS across geographical regions has suggested to be related differences distribution preceding infections, but this not studied on large scale. <h3>Methods</h3> We analyzed first 1,000 patients included International Outcome Study available biosamples (n = 768) for presence recent infection...
Background Neuralgic amyotrophy (NA) is a distinct peripheral nervous system disorder characterized by attacks of acute neuropathic pain and rapid multifocal weakness atrophy unilaterally in the upper limb. The current hypothesis that episodes are caused an immune-mediated response to brachial plexus, however, therapeutic strategies for NA have not been well established. Methods Results We retrospectively reviewed 15 case series NA; 10 patients received intravenous immunoglobulin (IVIg) with...
To clarify the differences in clinical characteristics between anti-GQ1b antibody-positive and antibody-negative Bickerstaff brainstem encephalitis (BBE).We compared 73 BBE cases with 10 cases. Their information sera were collected from various hospitals throughout Japan 2014 2017. The antibody was examined each serum sample by ELISA.We identified distinctive findings of cases: (1) upper respiratory infection sensory disturbance more common, (2) cell count or protein concentration lower CSF,...
Guillain-Barré syndrome (GBS) is an acute, self-limited, immune-mediated peripheral neuropathy. Current treatments for GBS include intravenous immunoglobulin (IVIg) and plasma exchange, which may not sufficiently benefit severely affected patients. This study evaluated the efficacy safety of eculizumab add-on therapy to IVIg (standard-of-care treatment) in patients with severe GBS.
To investigate the relationship between antibody reactivities against glycolipid complexes and clinical features in Miller Fisher syndrome (MFS), Bickerstaff brainstem encephalitis (BBE), Guillain-Barré with ophthalmoplegia (GBS-OP).Using glycoarray, antibodies 10 antigens (GM1, GM2, GM4, GD1a, GD1b, GQ1b, galactocerebroside, lactosylceramide, GA1, sulfatide) 45 consisting 2 of glycolipids were examined sera 63 patients GBS-OP, 37 MFS, 27 BBE.Antibodies to containing GQ1b identified 73%...
Abstract Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside are thought to play a key role clinical diversity disease and can be helpful practice. Extensive research into associations individual anti-ganglioside antibody specificities has been performed. Recent highlighted glycolipid complexes, combinations may alter binding, as...
LM1 is the predominant glycolipid in human peripheral nerve myelin and antibodies to LM1-containing ganglioside complexes are detected some patients with chronic inflammatory demyelinating polyneuropathy (CIDP). The clinical features of such have not yet been investigated.Serum LM1, a mixture GM1 (GM1/LM1), that GD1b (GD1b/LM1) were examined 75 consecutive CIDP. CIDP present series those previous reports investigated compared antibody-negative patients.Of CIDP, two had three anti-GM1/LM1...
ABSTRACT Introduction Neurofascin155 (NF155) is a target antigen for autoantibodies in subset of chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We report the cases 4 patients with anti‐NF155 immunoglobulin G4 (IgG4) antibody‐positive CIDP who underwent sural nerve biopsies. Results All were relatively young at onset. Three experienced tremors, and 2 had severe ataxia. Although response to intravenous was poor all patients, plasma exchange corticosteroids least partially...
We examined the clinical and serologic features of Guillain-Barré syndrome (GBS)-related diseases (GBSRDs), including GBS, Fisher (FS), Bickerstaff brainstem encephalitis (BBE), after influenza virus infection (GBSRD-I) to reveal potential underlying autoimmune mechanisms.We retrospectively investigated presence antiglycolipid antibodies against 11 glycolipids 63 patients with GBSRD-I. Autoantibody profiles were compared those 82 GBSRDs Campylobacter jejuni (GBSRD-C).The anti-GQ1b...
Spastic paraplegia 30 is a recently established autosomal recessive disease characterized by complex form of spastic associated with neuropathy. Homozygous mutations KIF1A reportedly lead to hereditary or sensory and autonomic neuropathy type 2 (HSAN2), whereas heterozygous can cause nonsyndromic syndromic intellectual disability (MRD9). Here we report the case 37-year-old female who presented gait disturbance complicated moyamoya disease.The patient exhibited hypotonia during infancy, after...
Deposition of myelin-associated glycoprotein (MAG) immunoglobulin M (IgM) antibodies in the sural nerve is a key feature anti-MAG neuropathy. Whether blood-nerve barrier (BNB) disrupted neuropathy remains elusive.We aimed to evaluate effect sera from at molecular level using our vitro human BNB model and observe change endothelial cells neuropathy.Diluted patients with (n = 16), monoclonal gammopathies undetermined significance (MGUS) 7), amyotrophic lateral sclerosis (ALS, n 10), healthy...
Complement is involved in the pathogenesis of neuroimmune disease, but detailed pathological roles complement pathway remain incompletely understood. Recently, eculizumab, a humanized anti-C5 monoclonal antibody, has been clinically applied against diseases such as myasthenia gravis and neuromyelitis optica spectrum disorders (NMOSD). Clinical application eculizumab also being investigated for another Guillain-Barré syndrome (GBS). However, while effectiveness NMOSD extremely high many...
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) has recently been attributed to biallelic repeat expansions in RFC1. More recently, the disease entity expanded atypical phenotypes, including chronic neuropathy without cerebellar ataxia or areflexia. Very RFC1 were found patients with Sjögren who had that did not respond immunotherapy. In this study was examined 240 acute neuropathies, 105 Guillain-Barré Miller Fisher syndrome, 76 inflammatory demyelinating...