A5100609647- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Lipid metabolism and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Diet, Metabolism, and Disease
- Pediatric health and respiratory diseases
- Alcohol Consumption and Health Effects
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Studies
- Orthopedic Surgery and Rehabilitation
- Pancreatic function and diabetes
- Atherosclerosis and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Immune cells in cancer
- Cancer Cells and Metastasis
- Ginseng Biological Effects and Applications
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Asthma and respiratory diseases
- Renal cell carcinoma treatment
- Acupuncture Treatment Research Studies
First Affiliated Hospital of Bengbu Medical College
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Institute of Hematology & Blood Diseases Hospital
2024
Anhui Medical University
2024
Jining First People's Hospital
2024
Second Hospital of Anhui Medical University
2024
Xi’an Children’s Hospital
2024
Xi'an Jiaotong University
2024
Central Hospital of Wuhan
2023
Abstract A critical pathogenic factor in the development of lethal liver failure is cell death induced by accumulation lipid reactive oxygen species. In this study, we discovered and illuminated a new mechanism that led to alcoholic disease via ferroptosis, an iron-dependent regulated death. Study vitro showed both necroptosis inhibitor ferroptosis inhibitors performed significantly protective effect on alcohol-induced death, while apoptosis autophagy had no such effect. Our data also...
Endothelial dysfunction and senescence are closely associated with cardiovascular diseases including atherosclerosis hypertension. Ginsenoside Rb1 (Rb1), the major active constituent of ginseng, has been investigated intensively because its anti‑obesity anti‑inflammatory effects. In a previous study, hydrogen peroxide (H2O2) was applied to induce human umbilical vein endothelial cell (HUVEC) aging. It demonstrated that Sirtuin‑1 (SIRT1) activated by protect HUVECs from H2O2‑induced...
The prevalence of gestational diabetes mellitus (GDM) has spurred investigations into various interconnected factors, among which gut dysbiosis is notably prominent. Although strongly associated with GDM, the specific role microbiome in pathogenesis GDM remains unknown. This study aims to explore from microbiota.
The effects of Tartary buckwheat bran extract (TBBE) on antioxidation status and lipid profile were determined in hyperlipemic rats. Seven-week-old male Wistar rats fed a high-fat diet to induce hyperlipemia with doses TBBE at 0.2 (low), 0.5 (medium), 1.0 (high) g/kg body weight. positive control group was the or supplemented Gynostemma pantaphyllum total glucoside tablet 0.032 negative basal diet. blood lipids, liver antioxidant-related parameters measured. indicated that could effectively...
Objective: To analyze the association between serum uric acid (SUA) and metabolic state in obese inpatients preliminarily explore potential mechanisms of hyperuricemia obesity. Methods: A total 153 were selected assigned based on SUA level to normal (NC group) or high (HUA) group. Patients' sex, age, height, weight, blood pressure, BMI, prevalence syndrome collected recorded. SUA, FPG, FIns, HOMA-IR, HOMA-IS, HbA 1c , TGs, TC, LDL-C, HDL-C levels tested. Pearson correlation analysis was...
BACKGROUND: KRAS gene mutations are well known as a key driver of advanced non–small cell lung cancer (NSCLC). The impact KRAS-mutant subtypes on the survival benefit from salvage chemotherapy is controversial. Here, we present real-world study in patients across China with NSCLC using website-based patient self-report system. METHODS: We identified total 75 diagnosed (determined by molecular sequencing) between 2014/5/9 and 2019/5/30. mutation were divided into G12C non-G12C groups for...
To describe the heterogeneity of electrodiagnostic (EDx) studies in Guillain-Barré syndrome (GBS) patients collected as part International GBS Outcome Study (IGOS).Prospectively clinical and EDx data were available 957 IGOS from 115 centers. Only first study was included current analysis.Median timing 7 days (interquartile range 4-11) symptom onset. Methodology varied between centers, countries regions. Reference values responding 103 centers derived locally 49%, publications 37% a...
Senescence of endothelial cells has been proposed to play an important role in dysfunction and atherogenesis. In the present study we aimed investigate whether ginsenoside Rb1, a major constituent ginseng, protects from H2O2-induced senescence. While H2O2 induced premature senescent-like phenotype human umbilical vein (HUVECs), as judged by increased senescence-associated β-galactosidase (SA-β-gal) activity, enlarged, flattened cell morphology sustained growth arrest, our results...
Intricate health problems, such as insulin resistance (IR) and its associated diseases, call for multi-targeted therapies with few side effects. Based on traditional Chinese medicine (TCM), Dai-Zong-Fang (DZF) is an herbal formula mainly composed of Rhizoma Coptidis (Huanglian) Fructus Aurantii Immaturus (Zhishi), which berberine naringin are the main constituents. Though DZF has been clinically used treatment IR metabolic syndrome decades, mechanism in vivo remains unknown. In present...
Background The role of RNA-binding fox one homolog 2 (RBFOX2) in the progression multiple tumors is increasingly supported by evidence. However, unclearness pertaining to expression RBFOX2, its prognostic potential, and correlation with tumor microenvironment (TME) pan-cancer persists. This study aims comprehensively investigate immunological value RBFOX2. Methods Cancer Genome Atlas Gene Expression Omnibus Genotype-Tissue (GTEx), TIMER2.0, Kaplan-Meier (K–M) Plotter, University Alabama at...
To investigate the effects of acute hyperglycemia on dexmedetomidine-induced preconditioning against renal ischemia-reperfusion injury.Sprague-Dawley rats were randomly arranged to normoglycemic (NG) or hyperglycemic group (HG), with each further divided into sham (no I/R injury), (ischemia-reperfusion) and dex (given by dexmedetomidine) groups. Acute was induced intraperitoneal injection (i.p.) 25% glucose (3 g/kg) 45 min before ischemia. Dexmedetomidine (50 μg/kg, i.p.) administrated 30...
Pleomorphic adenoma gene like-2 (PLAGL2) is a member of the PLAG family. Previous studies have revealed that overexpression PLAGL2 associated with many human cancers. However, it has been reported also plays as tumor suppressor. The precise role in prostate cancer (PCa) still unknown. aim this study was to investigate expression and prognostic value PCa. Data from microarray datasets demonstrated DNA copy number mRNA level were significantly increased PCa compared normal prostate. qRT-PCR...
Objective To analyze the correlation between ovarian reserve and thyroid function in women with infertility. Methods Retrospective analysis of data 496 infertility patients who visited clinic January 2019 December 2020. According to TSH level, it is grouped into <2.5 mIU/L, 2.5~4.0mIU/L ≥4.0 mIU/L or according positive/negative autoimmune antibody. The relationship was assessed through reserve, function, anti-Müllerian hormone (AMH) levels infertile patients. On other hand, are...
To observe the effects of interactive scalp acupuncture on upper limb motor function and activities daily living in patients with dysfunction after stroke.
Background This study was designed to assess oral ulcerative mucositis, C-reactive protein, blood pressure, heart rate and thyroid function in breast cancer patients relation the occurrence of posttraumatic stress disorder (PTSD). Methods A total 120 female women 100 healthy subjects were enrolled this study. PTSD status assessed by questionnaire. Before after treatment (modified radical mastectomy chemotherapy), serum samples collected measured for levels triiodothyronine (T3), thyroxine...