A5057101505- Zebrafish Biomedical Research Applications
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Pluripotent Stem Cells Research
- CAR-T cell therapy research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Renal and related cancers
- Breast Lesions and Carcinomas
- Erythrocyte Function and Pathophysiology
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Complement system in diseases
Institute of Hematology & Blood Diseases Hospital
2019-2024
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2021
Abstract Objectives Vitronectin (VTN) has been widely used for the maintenance and expansion of human pluripotent stem cells (hPSCs) as feeder‐free conditions. However, effect VTN on hPSC differentiation remains unclear. Here, we investigated role in early haematopoietic development hPSCs. Materials Methods A chemically defined monolayer system was applied to study different matrix or basement membrane proteins The integrin signalling VTN‐mediated by antagonists. Finally, small interfering...
Hypoxia enhances hematopoiesis with functional T cell potential from human pluripotent stem cells via arterial priming.
Hemogenic endothelial (HE) cells are specialized to give rise hematopoietic stem/progenitor during development. The underlying mechanisms that regulate endothelial-to-hematopoietic transition (EHT) of human HE not fully understand. Here, we identified platelet aggregation receptor-1 (PEAR1) as a novel regulator early development in pluripotent stem (hPSCs). We found the expression PEAP1 was elevated A subpopulation PEAR1+ overlapped with CD34+ CD144+ CD184+ CD73- arterial-type cells....
Objective To investigate the value and feasibility of wire-location surgical biopsies by mammograpy three-dimensional positioning system for non-palpable breast lesions. Methods Between April 2013 October 2015, sixty-seven women with lesions underwent surgery at Beijing Shijitan Hospital. Wire localization guided was performed before operation. Results All founded out were accurately localized excised. Seventeen cases (25.4%) malignant, 13 (19.4%) precancerous (including ductal...