A5022532985- Extracellular vesicles in disease
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Nuclear Structure and Function
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Genetic Syndromes and Imprinting
- Eosinophilic Disorders and Syndromes
- Neurogenesis and neuroplasticity mechanisms
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Cardiac Fibrosis and Remodeling
- Mechanical Circulatory Support Devices
- Nerve injury and regeneration
- Chemotherapy-induced cardiotoxicity and mitigation
- Mitochondrial Function and Pathology
- Chronic Lymphocytic Leukemia Research
- Fibroblast Growth Factor Research
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022-2025
University of Turin
2018-2025
Neuroscience Institute
2017-2021
The relevance of extracellular vesicles (EV) as mediators cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (ACS) subjected the RIPC sham procedures, may be a suitable therapeutic approach prevent IRI during Percutaneous-Coronary-Intervention (PCI). A double-blind, randomized, sham-controlled (NCT02195726)...
Cardiac laminopathies encompass a wide range of diseases caused by defects in nuclear envelope proteins, including cardiomyopathy, atrial and ventricular arrhythmias conduction system abnormalities. Two genes, namely LMNA EMD, are typically associated with these disorders part the routine genetic panel performed affected patients. Yet, there other markedly fewer known nesprins, encoded SYNE that play pivotal role connecting to cytoskeletal elements. So far, gene variants have been described...
Spino-Cerebellar-Ataxia type 38 (SCA38) is caused by missense mutations in the very long chain fatty acid elongase 5 gene, ELOVL5. The main clinical findings this disease are ataxia, hyposmia and cerebellar atrophy. Mice which Elovl5 has been knocked out represent a model of loss function hypothesis SCA38. In agreement with hypothesis, knock mice reproduced symptoms patients, motor deficits at beam balance test hyposmia. cortex showed reduction thickness molecular layer, already detectable 6...
The biological relevance of extracellular vesicles (EV) released in an ischemia/reperfusion setting is still unclear. We hypothesized that the inflammatory microenvironment prevents cardioprotection mediated by endothelial cell (EC)-derived vesicles. effects naïve EC-derived EV (eEV) or eEV response to interleukin-3 (IL-3) (eEV-IL-3) were evaluated cardiomyoblasts (H9c2) and rat hearts. In transwell assay, protected H9c2 exposed hypoxia/reoxygenation (H/R) more efficiently than eEV-IL-3....
Extracellular vesicles (EVs) are promising therapeutic tools in the treatment of cardiovascular disorders. We have recently shown that EVs from patients with Acute Coronary Syndrome (ACS) undergoing sham pre-conditioning, before percutaneous coronary intervention (PCI) were cardio-protective, while experiencing remote ischemic pre-conditioning (RIPC) failed to induce protection against ischemia/reperfusion Injury (IRI). No data on ACS recovered after PCI currently available. Therefore, we...
Abstract Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation other enzymes guarantees the normal levels of very long‐chain acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity myelin, is maintained by correct amount interaction between myelin proteins. We hypothesized that −/− mice, lack elongation substrates might cause alterations The analysis ultrastructure showed an enlarged...
Abstract Background Extracellular vesicles (EV) are recognized as carriers of relevant biological effects and have been identified regulators cell-to-cell communication contributing to several patho-physiological processes. These processes include angiogenesis/coagulation/tissue repair/inflammation. In ischemia/reperfusion (I/R) settings, along with the direct I/R itself, paracrine mechanisms associated activation inflammatory response, primary involving endothelial cells, crucial drivers...
Abstract A 38-year-old woman with curly hair was admitted at the Emergency Department of our Hospital for typical thoracic pain associated dyspnea and palpitations. Electrocardiogram showed sinus rhythm, 65 bpm, low voltages in peripheral leads fragmented QRS complex inferior negative T-waves anterior leads. Initial high-sensitivity cardiac troponin level 46326 ng/L (n.v. < 16 ng/L). At presentation patient treated Anakinra (anti-interleukin 1) Metoprolol 200 mg/die because a past...