A5008244067- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Retinal Imaging and Analysis
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- GDF15 and Related Biomarkers
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Nutrition and Health in Aging
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Viral Infections and Immunology Research
- IL-33, ST2, and ILC Pathways
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Ultrasound in Clinical Applications
- Sustainable Supply Chain Management
- Corporate Social Responsibility Reporting
National Heart Centre Singapore
2016-2025
Duke-NUS Medical School
2017-2025
Chinese Culture University
2022-2024
National University of Singapore
2021-2024
University of Massachusetts Chan Medical School
2023
British Heart Foundation
2023
University of Glasgow
2023
Changi General Hospital
2017
National University Heart Centre Singapore
2017
Singapore General Hospital
2017
Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal using noninvasive optical coherence tomographic angiography (OCT-A) adults with treated systemic hypertension and determined possible correlations ambulatory blood pressure (BP) renal parameters.This observational cross-sectional study consisted 153 normal eyes from 77 nondiabetic hypertensive [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]. Data on 24-h BP...
The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.REMODEL (Response the Myocardium to Hypertrophic Conditions Adult Population) an observational cohort asymptomatic essential hypertension. All participants underwent magnetic resonance assess for fibrosis: nonischemic late gadolinium enhancement (LGE), native T1, postcontrast extracellular volume fraction including/excluding LGE regions, interstitial (extracellular...
The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care.
Left ventricular hypertrophy (LVH) is a strong predictor of adverse outcomes. Although normalizing LV mass (LVM) to height exponents reduced variability from body size, specific recommendations for are lacking due scarcity normal cohorts define appropriate exponents. The authors aimed show the diagnostic and prognostic implications establishing sex, ethnicity, imaging modality. Nonoverweight/nonobese Asian healthy volunteers (n = 416) were used establish impact these was examined in separate...
Cardiovascular magnetic resonance (CMR) reference ranges have not been well established in Chinese. Here we determined normal cardiac and aortic healthy Singaporean Chinese investigated how these data might affect clinical interpretation of CMR scans. In 180 (20 to 69 years old; males, n = 91), comprehensive assessment was performed using the steady state free precision technique (3T Ingenia, Philips) images were analysed by two independent observers (CMR42, Circle Imaging). Measurements...
Abstract We investigated the characteristics of choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, urine microalbumin/creatinine ratio (MCR) were collected. Estimated...
Left ventricular (LV) non-compaction (LVNC) is defined by extreme LV trabeculation, but measured variably. Here we examined the relationship between quantitative measurement in trabeculation and myocardial deformation health disease determined clinical utility of semi-automated assessment trabeculations. Cardiovascular magnetic resonance (CMR) was performed 180 healthy Singaporean Chinese (age 20–69 years; males, n = 91), using balanced steady state free precession cine imaging at 3T. The...
BACKGROUND: Compared with patients hypertension only, those and diabetes (HTN/DM) have worse prognosis. We aimed to characterize morphological differences between HTN/DM using cardiovascular magnetic resonance; compare differentially expressed proteins associated myocardial fibrosis high throughput multiplex assays. METHODS: Asymptomatic underwent resonance: 438 (60±8 years; 59% males) 167 age- sex-matched (60±10 64% males). Replacement was defined as nonischemic late gadolinium enhancement...
Exercise cardiovascular magnetic resonance (ExCMR) has great potential for clinical use but its development been limited by a lack of compatible equipment and robust real-time imaging techniques. We developed an exCMR protocol using in-scanner cycle ergometer assessed performance in differentiating athletes from non-athletes. Free-breathing CMR (1.5T Aera, Siemens) was performed 11 (5 males; median age 29 [IQR: 28–39] years) 16 age- sex-matched healthy volunteers (7 26 [interquartile range...
Background This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods Results We conducted a cross-sectional of 118 adults hypertension (197 eyes). Patients underwent OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations (superficial deep retinal capillary density) adverse cardiac remodeling (left...
BACKGROUND Diffuse interstitial fibrosis is a potential therapeutic target because of its prognostic significance and reversibility. Sacubitril/valsartan may offer superior anti-fibrotic effects through dual inhibition neprilysin angiotensin receptors. REVERSE-LVH compared the efficacy sacubitril/valsartan versus valsartan in reduction diffuse patients with essential hypertension left ventricular hypertrophy (LVH), independent blood pressure (BP) reduction. METHODS Hypertensive participants...
Hypertensive left ventricular hypertrophy (HTN-LVH) is a leading cause of heart failure. Conventional patterns cardiac geometry do not adequately risk-stratify patients with HTN-LVH. Using cardiovascular magnetic resonance, we developed novel Remodeling Index (RI) that was designed to detect an exaggerated hypertrophic response hypertension and tested its potential hypertensive patients.The RI derived using LaPlace's Law (), normal ranges were established in 180 healthy volunteers. The...
Abstract We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients determined possible correlations with BP renal parameters. levels, serum creatinine urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. main outcome flow deficits (CFD) metrics...
Aims: Left ventricular ejection fraction is the conventional measure used to guide heart failure management, regardless of underlying etiology. global longitudinal strain (LV-GLS) by speckle tracking echocardiography (STE) a more sensitive intrinsic myocardial function. We aim establish LV-GLS as marker replacement fibrosis on cardiovascular magnetic resonance (CMR) and validate prognostic value thresholds associated with fibrosis. Methods results: were established in derivation cohort: 151...
Abstract Background Heart failure (HF) and diabetes are associated with increased incidence worse prognosis of each other. The prognostic value global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been established in HF patients diabetes. Methods In this prospective, observational study, consecutive ( n = 315) underwent CMR at 3T, including GLS, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV) mapping. Plasma biomarker...
This study employs the two-stage dynamic data envelopment analysis model to examine sustainability and corporate performances of 29 largest multinational enterprises in transport manufacturing industry from 2015 2019. The results show that, on average, has a positive relation performance is better than for all (MNEs). In addition, we also found that social responsibility (CSR) acts as moderator relationship between performances. Overall, American group leads others performance, followed by...
Abstract Aims Hypertensive left ventricular hypertrophy (LVH) is associated with increased cardiovascular events. We previously developed the remodelling index (RI) that incorporated (LV) volume and wall-thickness in a single measure of advanced hypertensive patients. This study examined prognostic potential RI reference to contemporary LVH classifications. Methods results Cardiovascular magnetic resonance was performed 400 asymptomatic The newly derived (EDV3t, where EDV LV end-diastolic t...
Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at eye, heart, brain, kidneys. As retina is only tissue body that allows direct imaging of small vessels, relationship hypertensive retinopathy signs with development disease states other organs have been extensively studied; large-scale epidemiological studies using fundus photography advanced semi-automated analysis software reported association end-organ includes...
The imaging features of dilated cardiomyopathy (DCM) overlap with physiological exercise-induced cardiac remodeling in active and otherwise healthy individuals. Distinguishing the two conditions is challenging. This study examined diagnostic prognostic roles exercise stress asymptomatic patients suspected DCM. Exercise cardiovascular magnetic resonance (CMR) was performed 60 DCM (dilated left ventricle and/or impaired systolic function on CMR), who also underwent DNA sequencing for...