A5012380371- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Bone Tissue Engineering Materials
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Optical Coherence Tomography Applications
- Ophthalmology and Visual Health Research
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Ocular Disorders and Treatments
- Drug-Induced Ocular Toxicity
- Older Adults Driving Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Connexins and lens biology
Singapore National Eye Center
2016-2025
Singapore Eye Research Institute
2016-2025
National University of Singapore
2012-2025
Duke-NUS Medical School
2014-2025
Malacca General Hospital
2022
Ministry of Health
2022
Changi General Hospital
2021
National University Hospital
2008-2021
National University Health System
2019
Vitreous Retina Macula Consultants of New York
2015-2018
Hydroxyapatite nodules in retinal drusen may indicate risk for progression to advanced age-related macular degeneration.
To comprehensively investigate spectral domain optical coherence tomography features associated with Type 3 neovascularization and determine the prevalence of each feature to develop an updated staging system for based on findings.The authors retrospectively analyzed 34 eyes new-onset neovascularization. Spectral images at onset neovascularization, immediately after first injection, final quiescent visit were presence specific features. In addition, when available, from before studied.Among...
Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced repeatability OCT-A measurements. Methods We obtained images on two separate visits 44 healthy eyes from subjects, each imaged with using Topcon DRI OCT Triton imaging system. The parafoveal vessel within a 1.5 mm radius centred over fovea was built-in...
<h3>Background/aims</h3> To assess the microvascular response of type 3 neovascularisation secondary to age-related macular degeneration (AMD) after antivascular endothelial growth factor (anti-VEGF) therapy using optical coherence tomography angiography (OCTA). <h3>Methods</h3> Consecutive patients diagnosed with AMD and based on clinical examination, structural fluorescein when available were retrospectively evaluated. En face OCTA imaging (3×3 mm scans) quantitative analysis was performed...
Abstract A major complication of hypertension is microvascular damage and capillary rarefaction a known hypertensive end-organ which confers higher risk systemic disease such as stroke cardiovascular events. Our aim was to study the effect on retinal microvasculature using non-invasive optical coherence tomography angiography (OCTA). We performed case-control 94 eyes participants with 46 normal control from Singapore Chinese Eye Study standardized protocol collect data past medical history...
Purpose To describe the early experiences of patients with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) whose treatment was switched to faricimab from other anti-vascular endothelial growth factor (VEGF) agents. Methods This is a prospective cohort eyes nAMD PCV that were previously treated anti-VEGF agents than faricimab. We evaluated visual acuity (VA), central subfield thickness (CST), volume (MV), pigment epithelial detachment (PED)...
To study the cross-sectional and en face optical coherence tomography angiography (OCTA) findings in Type 3 neovascularization (NV).Optical imaging of 27 eyes 23 patients with NV was analyzed 9 having consecutive follow-up OCTA studies.Type appeared as a linear high-flow structure on corresponding to tuft vessels seen OCTA. Cross-sectional seemed enable distinction between vascular nonvascular intraretinal hyperreflective foci. Two patterns flow were observed; Pattern 1 (11%): signal...
Purpose: To assess the ability of optical coherence tomography (OCT) alone and in combination with OCT angiography (OCTA) to differentiate polypoidal choroidal vasculopathy (PCV) from neovascular age-related macular degeneration, as compared fluorescein indocyanine green angiography. Methods: This is a cross-sectional study. All participants had standardized history, clinical examination including measurement best-corrected visual acuity, slit-lamp biomicroscopy, indirect fundus examination,...
To optimize the psychometric properties of age-related macular degeneration (AMD) quality life (QoL) item banks (IBs), and evaluate their performance using computerized adaptive testing (CAT) simulations. Cross-sectional, clinical study. 261 AMD patients answered 219 items within seven IBs: Activity Limitation (AL); Lighting (LT); Mobility (MB); Emotional (EM); Concerns (CN); Management (AM); Work (WK), referred to collectively as "MacCAT". The each IB (e.g. measurement precision; "fit";...
IMPORTANCE The potential benefit of adding photodynamic therapy (PDT) to intravitreal aflibercept injection (IAI) in eyes with polypoidal choroidal vasculopathy (PCV) remains unclear. OBJECTIVE To compare the functional and anatomical combination using reduced-fluence PDT (RF-PDT) plus IAI vs monotherapy participants PCV. DESIGN, SETTING, AND PARTICIPANTS This double-masked, sham-controlled, randomized clinical trial was conducted at 2 centers Singapore from January 2021 June 2024 for aged...
Aim To newly describe a spectral-domain (SD) optical coherence tomography angiography (OCTA) for the cornea and directly compare two OCTA system scans of same eyes with corneal vascularisation. Methods Cross-sectional, observational, comparative case series. We performed sequential (10 10 subjects vascularisation,4 each eye) repeated using split-spectrum amplitude decorrelation algorithm (SSADA, AngioVue; Optovue Inc, USA) SD (Angioscan; Nidek Co. Ltd, Japan) in region interest. analysed all...
Purpose . To describe a novel technique of adapting swept-source optical coherence tomography angiography (OCTA) to image corneal vascularization. Methods In this pilot cross-sectional study, we obtained 3 × mm scans, where 100,000 A-scans are acquired per second with axial resolution 8 μ m and lateral 20 m. This was performed manual “XYZ” focus without the anterior segment lens, until corneoscleral surface clearly seen vessels interest were in on corresponding red-free image. En face scans...
Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes varying levels DR. Optical coherence tomography angiography (OCTA) quantified superficial deep perifoveal vessel densities foveal avascular zone areas. Retinal sensitivity was measured using microperimetry. retinal were correlated. Results: Deep density decreased increasing severity DR (adjusted mean 51.93...