A5050032015- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Circadian rhythm and melatonin
- Ocular Oncology and Treatments
- Visual perception and processing mechanisms
Singapore National Eye Center
2018-2025
Singapore Eye Research Institute
2022-2025
Duke-NUS Medical School
2024
Abstract A major complication of hypertension is microvascular damage and capillary rarefaction a known hypertensive end-organ which confers higher risk systemic disease such as stroke cardiovascular events. Our aim was to study the effect on retinal microvasculature using non-invasive optical coherence tomography angiography (OCTA). We performed case-control 94 eyes participants with 46 normal control from Singapore Chinese Eye Study standardized protocol collect data past medical history...
To evaluate the ability of chromatic pupillometry to reveal abnormal pupillary responses light in patients with early-stage primary open-angle glaucoma (POAG) and test whether degree pupillometric impairment correlates structural hallmarks optic nerve damage disease.Cross-sectional study.Forty-six POAG (63.4±8.3 years, 63% male, 87% ethnic-Chinese) 90 age-matched healthy controls (61.4±8.6 34% 89% ethnic-Chinese). Patients had a visual field mean deviation (VFMD) -6 decibels or better on...
IMPORTANCE The potential benefit of adding photodynamic therapy (PDT) to intravitreal aflibercept injection (IAI) in eyes with polypoidal choroidal vasculopathy (PCV) remains unclear. OBJECTIVE To compare the functional and anatomical combination using reduced-fluence PDT (RF-PDT) plus IAI vs monotherapy participants PCV. DESIGN, SETTING, AND PARTICIPANTS This double-masked, sham-controlled, randomized clinical trial was conducted at 2 centers Singapore from January 2021 June 2024 for aged...
To assess 5-year cumulative incidence and risk factors of fellow eye involvement in Asian neovascular age-related macular degeneration (nAMD) polypoidal choroidal vasculopathy.In a prospective cohort study nAMD vasculopathy, the eyes were evaluated for exudation. The exudation was compared between vasculopathy.A total 488 patients studied. 16.2% (95% confidence interval: 12.0-20.2). Polypoidal vasculopathy with first associated lower progression (9.8% [95% 5.1-14.3]) vs. 22.9% 15.8-29.3], P...
Purpose: We describe an atypical presentation of 11-year-old female with enhanced S-cone syndrome (ESCS). Methods: Case report. The patient underwent a thorough ophthalmic examination and investigations such as colour fundus photography, optical coherence tomography, autofluorescence, fluorescein indocyanine angiography, electroretinogram genetic testing. After determining the presence secondary choroidal neovascularization, we treated her intravitreal Ranibizumab injections. present...
This case series describes responses to faricimab treatment in opposite directions different fluid compartments four patients with polypoidal choroidal vasculopathy (PCV). Despite reductions retinal (SRF) and stable visual acuity following treatment, all developed pigment epithelium (RPE) elevation. Over a 12-15 months follow-up, three exhibited gradual decrease RPE elevation, one resolving completely. These findings suggest that PCV may respond differently add the understanding of by...