A5038615806- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Gut microbiota and health
- Connective Tissue Growth Factor Research
- CAR-T cell therapy research
- Clostridium difficile and Clostridium perfringens research
- Renal cell carcinoma treatment
- Genomics and Phylogenetic Studies
- Vascular Malformations and Hemangiomas
- S100 Proteins and Annexins
- Bladder and Urothelial Cancer Treatments
- Eosinophilic Disorders and Syndromes
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
Duke-NUS Medical School
2020-2025
Southern Medical University
2021-2023
Nanfang Hospital
2021-2023
Beijing Children’s Hospital
2017
The role of lung microbiota in non-small cell cancer remains unclear. We investigated the characteristics and functional roles cancer. Bronchoalveolar lavage fluid samples were obtained from patients with (n = 46) benign disease 29). differences composition gene expression between analyzed using 16s rRNA sequencing. oncogenic genus (Veillonella) was then evaluated progression C57 BL/6 mice. Compared to disease, significantly altered, both terms α- β-diversity. In bacterial composition, group...
Clinical risk scores in chronic myeloid leukemia (CML) are inadequate for identifying phase (CP) patients at high-risk of blast crisis (BC) progression. The lack accurate predictive tests hamper timely interventions, including stem cell transplants, that more effective early disease. By interrogating a single atlas primary imatinib resistance BC-like gene expression signature, we identify aberrant CD42A+ megakaryocytic and CD10+CD19+ lymphoid progenitor expansion, as well STAT1- IFNγ-related...
Enrichment of Veillonella parvula in the lung microbiota is strongly associated with non-small cell cancer (NSCLC) and induces progression adenocarcinoma vivo, but its actual role mechanism remain unexplored. This study analyzed correlation between NSCLC V. abundance based on 16 s rRNA sequencing results. The effects were observed vivo vitro using a C57 bl/6j mouse tumor-bearing model, bacterial co-culture combined transcriptome sequencing, TCGA database to explore validate growth promotion...
Abstract Purpose Primary pulmonary lympho-epithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC). Currently, there still lack research data on anti-angiogenic therapy advanced PPLELC. The purpose this study was to investigate the efficacy and safety combined with chemotherapy compared traditional for these patients. Methods Advanced PPLELC patients admitted six grade A hospitals from January 2013 2021 were selected. received (AT group) or (CT...
Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare malignancy that lacks specific biomarkers. N6-methyladenosine (m6 A) the most widespread internal modification of messenger RNA (mRNA), and its dysregulation involved in development many cancers. However, expression m6 A genes pLELC their roles are unknown. We obtained an exosomal transcriptome data set patients diagnosed with healthy controls using sequencing identified differentially expressed (DEGs) two groups R software. The...
Abstract Purpose: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC). Currently, there still lack research data on anti-angiogenic therapy advanced PPLELC. The purpose this study was to investigate the efficacy and safety combined with chemotherapy compared traditional for these patients.Methods: Advanced PPLELC patients admitted six grade A hospitals from January 2013 2021 were selected. received chemotherapy(AT group)...