A5049861606- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- RNA modifications and cancer
- Immune cells in cancer
- Quinazolinone synthesis and applications
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Bone health and treatments
- Cancer Research and Treatments
- SARS-CoV-2 detection and testing
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
Duke-NUS Medical School
2012-2024
National University Cancer Institute, Singapore
2014-2024
National University of Singapore
2012-2024
KK Women's and Children's Hospital
2020-2024
SingHealth
2020
Hong Kong University of Science and Technology
2007-2012
University of Hong Kong
2007-2009
Chromosomal translocations involving the N-terminal approximately 250 residues of Ewings sarcoma (EWS) oncogene produce a group EWS fusion proteins (EFPs) that cause several distinct human cancers. EFPs are potent transcriptional activators and interact with other required for mRNA biogenesis, indicating induce tumorigenesis by perturbing gene expression. Although were discovered more than decade ago, molecular analysis has been greatly hindered repetitive activation domain (EAD) structure,...
To determine whether the frequencies of SARS-CoV-2-specific T cells are sufficiently high in blood convalescent donors and it is technically feasible to manufacture clinical-grade products overnight for T-cell therapy assessment COVID-19 immunity.One unit whole or leukapheresis was collected from each donor following standard bank practices. The leukocytes were stimulated using overlapping peptides SARS-CoV-2, covering immunodominant sequence domains S protein complete N M proteins....
Cancer cells, including in chronic myeloid leukemia (CML), depend on the hypoxic response to persist hosts and evade therapy. Accordingly, there is significant interest drugging cancer-specific responses. However, a major challenge identifying differential druggable responses between leukemic normal cells. Previously, we found that arginase 2 (ARG2), an enzyme of urea cycle, overexpressed CML but not progenitors. ARG2 target hypoxia inducible factors (HIF1-α HIF2-α), required for generation...
Aberrant chromosomal fusion of the Ewings sarcoma oncogene (EWS) to several different cellular partners gives rise Ewing's family oncogenic proteins [EWS (EFPs)] and associated tumors (EFTs). EFPs are potent transcriptional activators dependent on N-terminal region EWS [the activation domain (EAD)], this function is thought be central EFT oncogenesis maintenance. Thus, promising therapeutic targets, detailed molecular studies EAD will pivotal for exploring potential. For many reasons,...
SUMMARY Background Adoptive therapy with SARS-CoV-2 specific T cells for COVID-19 has not been reported. The feasibility of rapid clinical-grade manufacturing virus-specific from convalescent donors demonstrated this or prior pandemics. Methods One unit whole blood was collected each donor following standard bank practices. After the plasma separated and stored separately, leukocytes were stimulated using overlapping peptides SARS-CoV-2, covering immunodominant sequence domains S protein...
Post-transplant or hematological cancer patients have a higher risk of mortality after infection with ancestral and early variants severe acute respiratory syndrome (SARS)-CoV-2. Adoptive cell therapy (ACT) virus-specific T cells (VSTs) could augment endogenous immunity to avoid disease deterioration before viral clearance.
Background: Post-transplant or haematological cancer patients have a higher risk of mortality after infection with ancestral and early variants SARS-CoV-2 . Adoptive cell therapy (ACT) virus-specific T cells could augment endogenous immunity to avoid disease deterioration before viral clearance.Methods: We established third-party specific (COVID-T) bank in 2020 (NCT04351659) using convalescent and/or vaccinated donors. In phase I/II study (NCT04457726), thirteen adult paediatric patients,...
Abstract The use of tyrosine kinase inhibitors (TKI) to target oncogenic kinases has led remarkable responses in patients with chronic myeloid leukemia (CML) and EGFR-mutated non-small cell lung cancer (EGFR NSCLC). However, a significant subset have minimal or very brief response. It been suggested that germline polymorphisms may account for this upfront TKI resistance, identifying such will allow personalization targeted therapy achieve optimal patients. Using paired-end DNA sequencing, we...