A5072559424- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Consumer Behavior in Brand Consumption and Identification
- Socioeconomic Development in MENA
- Customer Service Quality and Loyalty
- Marketing and Advertising Strategies
- Higher Education and Employability
- Consumer Retail Behavior Studies
- Digital Marketing and Social Media
- Career Development and Diversity
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Grit, Self-Efficacy, and Motivation
- RNA Research and Splicing
- Economic Growth and Development
- Chronic Myeloid Leukemia Treatments
- Scientific Computing and Data Management
- Chronic Lymphocytic Leukemia Research
- Entrepreneurship Studies and Influences
- Distributed and Parallel Computing Systems
University of Kuala Lumpur
2020-2021
Iqra University
2012-2020
Institute of Business Management
2020
Agency for Science, Technology and Research
2007-2015
Genome Institute of Singapore
2007-2012
Bioinformatics Institute
2004-2007
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue these is not yet available their characteristic localizations also poorly understood. Because RNA represents direct output genetic information encoded by genomes a significant proportion cell's regulatory capabilities focused on its synthesis, processing, transport, modification translation, generation such crucial for...
The protooncogene MYC encodes the c-Myc transcription factor that regulates cell growth, proliferation, cycle, and apoptosis. Although deregulation of contributes to tumorigenesis, it is still unclear what direct Myc-induced transcriptomes promote transformation. Here we provide a snapshot genome-wide, unbiased characterization Myc binding targets in model human B lymphoid tumor using ChIP coupled with pair-end ditag sequencing analysis (ChIP-PET). potentially occupies > 4,000 genomic loci...
MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators gene expression. Many miRNAs expressed in the developing brain and regulate multiple aspects neural development, including neurogenesis, dendritogenesis, synapse formation. Rett syndrome (RTT) is progressive neurodevelopmental disorder caused by mutations encoding methyl-CpG–binding protein 2 ( MECP2 ). Although Mecp2 known to act global transcriptional regulator, directly regulated not...
Gastric cancer is the second highest cause of global mortality. To explore complete repertoire somatic alterations in gastric cancer, we combined massively parallel short read and DNA paired-end tag sequencing to present first whole-genome analysis two adenocarcinomas, one with chromosomal instability other microsatellite instability.Integrative de novo assemblies revealed architecture a wild-type KRAS amplification, common driver event cancer. We discovered three distinct mutational...
Using a long-span, paired-end deep sequencing strategy, we have comprehensively identified cancer genome rearrangements in eight breast genomes. Herein, show that 40%–54% of these structural genomic result different forms fusion transcripts and 44% are potentially translated. We find single segmental tandem duplication spanning several genes is major source the gene both cell lines primary tumors involving adjacent placed reverse-order position by event. Certain other mutations, however,...
Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts study human structural variations (SVs). The use of insert size allows the identification breakpoints within repetitive or homology-containing regions few kilobases and results higher physical coverage compared with small libraries same effort. have applied this comprehensively characterize SVs 15 two...
Identification of unconventional functional features such as fusion transcripts is a challenging task in the effort to annotate all DNA elements human genome. Paired-End diTag (PET) analysis possesses unique capability accurately and efficiently characterize two ends fragments, which may have either normal or unusual compositions. This nature PET makes it an ideal tool for uncovering residing Using approach comprehensive transcriptome analysis, we were able identify derived from genome...
The purpose of this study is to investigate the ways achieving Science, Technology and Innovation (STI) in UAE. Previously, sustainability within an entrepreneurship context has been related economic viability as opposed its broadest sense. Through a survey research method, we have highlighted effects three independent variables two intervening on important outcomes, innovation, need for achievement motivation, which ultimately contributes towards STI. These data collected from students...
Purpose This study aims to examine the drivers of sustainable entrepreneurship intention (SEI) among university students in Pakistan. Design/methodology/approach A survey-based methodology was used collect data from participants. Further, this covariance-based structural equation modeling test proposed hypotheses. Findings The findings confirm that model is effective as it explains 83% variance predict SEI students. Originality/value research has contributed literature and valuable insights...
Structural variations (SVs) contribute significantly to the variability of human genome and extensive genomic rearrangements are a hallmark cancer. While DNA paired-end-tag (DNA-PET) sequencing is an attractive approach identify SVs, current application PET with short insert size can be insufficient for comprehensive mapping SVs in low complexity repeat-rich regions. We employed recently developed procedure generate data using large inserts 10–20 kb compared their characteristics (1 kb)...
In order to investigate the purchase intention of customers, and its relationship with perceived humor, this research analysesdifferent types humor that havebeen used in advertising campaigns. regard, multi-mediation analysis has been applied keeping mind perspective advertising; moreover, attitudes towards advertisement, brand are as sequential mediators. addition, self-monitoring message arguments have also included moderators estimate interaction effect theproposedmodel. The data gathered...
Abstract Summary: The algorithm MGR enables the reconstruction of rearrangement phylogenies based on gene or synteny block order in multiple genomes. Although has been successfully applied to study evolution different sets species, its utilization hampered by prohibitive running time for some applications. In current work, we have designed new heuristics that significantly speed up tool without compromising accuracy. Moreover, developed a web server (webMGR) includes elaborate output...