A5022055760- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Genomics and Chromatin Dynamics
- Stress Responses and Cortisol
- Economic and Financial Impacts of Cancer
- Hematopoietic Stem Cell Transplantation
- Chromosomal and Genetic Variations
- Sleep and Work-Related Fatigue
- Palliative Care and End-of-Life Issues
- Sleep and Wakefulness Research
- Lymphoma Diagnosis and Treatment
- Nursing Education, Practice, and Leadership
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- Cancer survivorship and care
- Tryptophan and brain disorders
- Youth Substance Use and School Attendance
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Mental Health Research Topics
- Developmental Biology and Gene Regulation
- Acute Lymphoblastic Leukemia research
- Plant Molecular Biology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare Technology and Patient Monitoring
Cleveland Clinic
2001-2024
Stony Brook University
2019-2024
University of Massachusetts Amherst
2024
North Carolina Agricultural and Technical State University
2019-2023
ImmuNext (United States)
2023
Children's Hospital Colorado
2023
University of Colorado Denver
2023
United States Department of Veterans Affairs
2021
Milwaukee VA Medical Center
2010-2021
Brigham Young University
2019
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue these is not yet available their characteristic localizations also poorly understood. Because RNA represents direct output genetic information encoded by genomes a significant proportion cell's regulatory capabilities focused on its synthesis, processing, transport, modification translation, generation such crucial for...
Uniform processing and detailed annotation of human, worm fly RNA-sequencing data reveal ancient, conserved features the transcriptome, shared co-expression modules (many enriched in developmental genes), matched expression patterns across development similar extent non-canonical, non-coding transcription; furthermore, are used to create a single, universal model predict gene-expression levels for all three organisms from chromatin at promoter. In this paper modENCODE consortium reports on...
Drosophila melanogaster cell lines are important resources for biologists. Here, we catalog the expression of exons, genes, and unannotated transcriptional signals 25 lines. Unannotated transcription is substantial (typically 19% euchromatic signal). Conservatively, identify 1405 novel transcribed regions; 684 these appear to be new exons neighboring, often distant, genes. Sixty-four percent genes expressed detectably in at least one line, but only 21% detected all Each line expresses, on...
OBJECTIVE: To report a case of imatinib-induced hepatotoxicity after concurrent ginseng ingestion in patient with chronic myelogenous leukemia (CML). CASE SUMMARY: A 26-year-old man CML who had taken imatinib 400 mg daily for 7 years no complications presented right upper quadrant pain. Laboratory test results included alanine aminotransferase 1069 U/L, aspartate 481 alkaline phosphatase 124 IU/L, total bilirubin 1.4 mg/dL, albumin 4.0 g/dL, and international normalized ratio 1.08. Liver...
Angelman syndrome is a neurological disorder whose symptoms include severe mental retardation, loss of motor coordination, and sleep disturbances. The disease caused by function UBE3A, which encodes HECT-domain ubiquitin ligase. Here, we generate Drosophila model for the disease. results several experiments show that functions human UBE3A its fly counterpart, dube3a, are similar. First, expression Dube3a enriched in nervous system, including mushroom bodies, seat learning memory. Second,...
Childhood stress and trauma are associated with substance use disorders in adulthood, but the neurological changes that confer increased vulnerability largely unknown. In this study, maternal separation (MS) stress, restricted to pre-weaning period, was used as a model study mechanisms of protracted effects childhood stress/traumatic experiences on binge drinking impulsivity. Using an operant self-administration delay discounting assay measure impulsive-like behavior, we report early life...
Erwinia amylovora is a plant pathogen from the Erwiniaceae family and causative agent of devastating agricultural disease fire blight. Here we characterize eight lytic bacteriophages E. that isolated Wasatch front (Utah, USA) are highly similar to vB_EamM_Ea35-70 which was in Ontario, Canada. With genome size ranging 271-275 kb, this novel jumbo bacteriophages. These were further characterized through genomic proteomic comparison, mass spectrometry, host range burst size. Their proteomes...
Stressful neighborhood environments are known to adversely affect health and contribute disparities but underlying mechanisms not well understood. Healthy sleep can provide a respite from sustained sympathetic nervous system (SNS) activity. Our objective was evaluate relationships between stress nocturnal daytime SNS parasympathetic (PNS) Eighty-five urban-residing African Americans (56.5% female; mean age of 23.0) participated. Evaluation included surveys sleep-related vigilance, continuous...
6565 Background: Due to the rising cost of cancer care, even well-insured patients are at risk for financial toxicity. Cancer treatment costs can be challenging and families because increasing deductibles, premiums frequent co-payments. At Cleveland Clinic Centers, our goal is identify distress help ease stress hardship associated with care. Methods: In 2015 we initiated huddles all new ensure seven day access as well out network authorizations. During this work identified need a position...
Summary Compromised sleep and increased sympathetic nervous system ( SNS ) activity are implicated in the pathogenesis of, disparities in, cardiovascular disease. Parasympathetic dominance during may be important for health. Sleep autonomic balance influence immune activity, which impacts atherogenesis. We evaluated relationships between morning levels of activating cytokines, C‐reactive protein CRP interleukin IL )‐6. Ninety‐four (59 female) young adult African Americans without medical...
In the United States, during Coronavirus Disease 2019 (COVID-19) pandemic, patients with COVID-19 overwhelmed available intensive care beds, staffing levels were unpredictable, and personal protective equipment was limited. The safety of situating electronic infusion pumps outside patient rooms evaluated using an internal risk assessment. Based on a low level risk, procedure developed to direct clinicians as when this process is appropriate national crisis. A standardized analysis,...
124 Background: Due to the rising cost of cancer care, even well-insured patients are at risk for financial toxicity. Cancer treatment costs can be challenging and families because increasing deductibles, premiums frequent co-payments. At Cleveland Clinic Centers, our goal is identify distress help ease stress hardship associated with care. Methods: The Financial Navigator (FN) role was created in 2016 complete benefits investigations determine covered services minimize patient’s out pocket...
Abstract Creating community among new graduate students in a COVID world prompted the development of two-week virtual orientation program for engineering and applied sciences at research university. Despite complexity multiple time zones, technology challenges, space, sought to accomplish three goals: (1) building students; (2) intellectual engagement with faculty home department; (3) career as foundation their overall school experience. Participants (N=350 MS or PhD students) were...
e13695 Background: Health inequities among underserved populations in the U.S. are complex and derive from unequal access to quality healthcare. Addressing these disparities requires a coordinated effort multiple stakeholders. Genentech’s Equity Regional Symposia Program was created reduce healthcare by convening stakeholders representing community, patient, academic, policy, health care interests. Methods: Specific criteria were employed identify hosting locations, including regions with...