A5067210846- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Body Contouring and Surgery
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Pelvic and Acetabular Injuries
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Sports injuries and prevention
- Neuroendocrine Tumor Research Advances
- Gastroesophageal reflux and treatments
- Minimally Invasive Surgical Techniques
- Intraperitoneal and Appendiceal Malignancies
- Burkholderia infections and melioidosis
- Traumatic Ocular and Foreign Body Injuries
- Abdominal vascular conditions and treatments
- Gout, Hyperuricemia, Uric Acid
Sheffield Teaching Hospitals NHS Foundation Trust
2025
Tan Tock Seng Hospital
2013-2022
Gastroenterology Medical Center and Hospital
2017
Singapore General Hospital
2005
Walsall Healthcare NHS Trust
1995
Pfizer (United States)
1990
Objective An unmet need exists for a non-invasive biomarker assay to aid gastric cancer diagnosis. We aimed develop serum microRNA (miRNA) panel identifying patients with all stages of from high-risk population. Design conducted three-phase, multicentre study comprising 5248 subjects Singapore and Korea. Biomarker discovery verification phases were done through comprehensive miRNA profiling multivariant analysis 578 candidates in retrospective cohorts 682 subjects. A clinical was developed...
Introduction Robotic surgery is useful in areas with difficult access like the pelvis. The ideal indications for robotic are still to be established. neck area, especially thyroid gland poses a challenge many endoscopic surgeons. this area due its excellent magnification and endowrist function. We present our initial experience thyroidectomy using bilateral axillary breast approach (BABA). Methods Results Between March May 2008, 15 patients diagnosed papillary cancer underwent...
Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched open chromatin and shaped by structure. We identified seven rearrangement hot spots 136 fusions. In three out 100 GC cases, found recurrent between CLDN18, tight junction gene, ARHGAP26, encoding RHOA inhibitor. Epithelial cell lines expressing...
Gastric cancer is the second highest cause of global mortality. To explore complete repertoire somatic alterations in gastric cancer, we combined massively parallel short read and DNA paired-end tag sequencing to present first whole-genome analysis two adenocarcinomas, one with chromosomal instability other microsatellite instability.Integrative de novo assemblies revealed architecture a wild-type KRAS amplification, common driver event cancer. We discovered three distinct mutational...
Objective To investigate the incidence of gastric cancer (GC) attributed to intestinal metaplasia (IM), and validate Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate GC. Methods A prospective, longitudinal multicentre study was carried out Singapore. The participants comprised 2980 patients undergoing screening gastroscopy standardised mucosal sampling, from January 2004 December 2010, scheduled endoscopies at year...
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely performed. Indications for these procedures have been extended in Korea Japan. The aim was to evaluate whether indications safe.All patients who had surgery early gastric cancer at Seoul National University Bundang Hospital between May 2003 December 2007 were identified from a prospective database. Lymph node status examined met EMR undergone surgical resection.Of with cancers, 129 or ESD three (2.3 per...
The aim of the study was to compare clinical symptoms between Billroth II (B-II) and Roux-en-Y (R-Y) reconstruction after distal subtotal gastrectomy (DG) for gastric cancer.Surgery is mainstay curative treatment cancer. technique DG remains controversial. Both B-II R-Y are popular methods.This a prospective multicenter randomized controlled trial. From October 2008 2014, 162 patients who underwent were randomly allocated (n = 81) groups. primary endpoint Gastrointestinal (GI) Symptoms Score...
Abstract We conducted a retrospective study to examine the role of Collatamp G in reducing postoperative surgical site infection (SSI) patients with different wound classes. Ninety-two (62 men and 30 women; mean age, 58 years; range, 29–88 years) who had undergone surgery between December 2009 November 2011 Tan Tock Seng Hospital application their before closure were included study. The primary endpoint was development any superficial within 1 month postoperatively. Of 92 studied, 9 (10%)...
Simultaneous organ resection is performed in 10% of laparoscopic gastrectomies for gastric cancer. The purpose this study to investigate the feasibility and safety simultaneous with gastrectomy cancer.We retrospectively reviewed medical records from a prospectively collected database patients who underwent May 2003 April 2012 single center. were classified into three groups: gastrectomy-only (no [NS]) group as control, combined (CB) characterized by additional due tumor invasion extensive...
The superiority of laparoscopic repair over open incisional hernias (IHs) in the elective setting is still controversial. Our study aimed to compare postoperative outcomes and IH an Asian population.This retrospective was conducted acute general hospital Singapore between 2010 2015. Inclusion criteria were setting, IHs with diameter 3-15 cm, location at ventral abdominal wall. We excluded patients who underwent emergency repair, had recurrent or loss wall domain (i.e. hernia sac containing...
279 Background: Peritoneal recurrence of gastric cancer after curative surgical resection is common and portends a poor prognosis. Preliminary studies suggest extensive intraoperative peritoneal lavage (EIPL) may reduce the risk improve survival. We sought to perform randomized phase III study definitively establish role performing EIPL gastrectomy. Methods: This prospective, open-label, 3 multicentre randomised controlled trial involving 22 hospitals from Korea. China, Japan, Malaysia...
Laparoscopic resection of gastrointestinal stromal tumor (GIST) has increased popularity with studies showing good outcomes for patients tumors <5 cm, a shorter hospital stay, lower blood loss, and morbidity. Our study aims to audit the clinical profile surgical GISTs, an evaluation laparoscopic versus open surgery prognostic role positive R1 margins. In our retrospective study, 62 GIST who underwent were included further analysis was made 48 gastric GISTs patients. total, 33 resection,...