A5074307736- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Clostridium difficile and Clostridium perfringens research
- Alcohol Consumption and Health Effects
- Neonatal Health and Biochemistry
- Gastrointestinal disorders and treatments
- Potassium and Related Disorders
- Extracellular vesicles in disease
- Nonmelanoma Skin Cancer Studies
- Inflammasome and immune disorders
- Circular RNAs in diseases
Singapore General Hospital
2014-2024
Duke-NUS Medical School
2018-2022
SingHealth
2022
SingHealth Duke-NUS Academic Medical Centre
2020-2021
Eastern Hepatobiliary Surgery Hospital
2015
University of Birmingham
2015
Second Military Medical University
2015
NIHR Birmingham Liver Biomedical Research Unit
2015
Queen Elizabeth Hospital Birmingham
2015
Hepatocellular carcinoma (HCC) is the fifth most common cancer with high mortality, due to late diagnosis and limited treatment options. Blood miRNAs, which circulate in a highly stable, cell-free form, show promise as novel potential biomarkers for early detection of HCC. Whole miRNome profiling was performed identify deregulated miRNAs between HCC normal healthy (NH) volunteers. These were validated an independent cohort HCC, NH chronic Hepatitis B (CHB) volunteers finally 3rd comprising...
Background & AimsHepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated epitopes are recognized by T cells and their presence in can be used to select HBV-specific T-cell receptors (TCRs) for immunotherapy.MethodsHCC negative antigens, based on immunohistochemistry, were analyzed the messenger RNAs (mRNAs) real-time...
Patients transplanted for autoimmune hepatitis (AIH) are at risk of recurrent disease. Our current practice is to maintain long-term low-dose corticosteroids with additional immunosuppressive agents. This study describes the implications on patients' outcomes, sepsis, and osteoporosis. We collected data patients between January 1999 October 2014 in a single center who survived more than 6 months. AIH recurrence was diagnosed by combination histology, raised immunoglobulin G levels, exclusion...
Background and Aims HBV‐specific T‐cell receptor (HBV‐TCR) engineered T cells have the potential for treating HCC relapses after liver transplantation, but their efficacy can be hampered by concomitant immunosuppressive treatment required to prevent graft rejection. Our aim is molecularly engineer TCR‐T that could retain polyfunctionality in such patients while minimizing associated risk of organ Approach Results We first analyzed how drugs interfere with vivo function transplanted HBV‐HCC...
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. The prevalence of IBS in Asian countries varies from 2.9% to 15.6%. does not result increased mortality, but associated with psychological distress and disruption work sleep. Consequently, the evaluation health-related quality life (HRQoL) an important outcome measure for patients since it provides holistic assessment patient's emotional, social physical function. However, some HRQoL tools can be time-consuming apply....
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and closely related to metabolic syndrome its risk factors. Worldwide, epidemiological studies have reported NAFLD prevalence rates of 5% 30% depending on geographical variations. While data suggest a progressively increasing factors in Singapore, there are limited about per se community. We aim explore perceptions Singapore.Attendees at gastroenterology public forum were enrolled cross-sectional observational study...
Acute-on-chronic liver failure (ACLF) is characterised by a sudden deterioration of underlying chronic disease, resulting in increased rates mortality and transplantation. Early prognostication can benefit optimal allocation resources.ACLF was defined as per the disease criteria Asian Pacific Association for Study Liver. Inpatient discharge summaries from between January 2001 April 2013 were reviewed. The primary outcome or transplantation within 60 days onset ACLF. Absolute 'model end-stage...
Repeat liver resection (RLR) and salvage transplantation (SLT) are viable treatment options for recurrent hepatocellular carcinoma (HCC). With possibly superior survival outcomes than RLR, SLT is however, limited by graft availability poses increased perioperative morbidity. In this study, we seek to compare the of RLR patients with HCC.Between 1999 2018, 94 16 consecutive who underwent respectively were identified. Further retrospective subgroup analysis was conducted, comparing via...
Salvage liver transplantation (SLT) is a therapeutic strategy for recurrent hepatocellular carcinoma (HCC). However, it remains controversial with compromised survival outcomes and increased perioperative morbidity compared to primary transplant (PLT). In the present work, we describe our institution's experience on SLT by comparing of PLT HCCs.Retrospective analysis was conducted 49 patients from 2006-2017. A comparative carried out between 14 35 patients.SLT demonstrated significantly...
BACKGROUND:In solid organ transplant (SOT) and hematopoietic stem cell (HSCT) recipients, coronavirus disease 2019 (COVID-19) can contribute to a severe clinical course an increased risk of death. Thus, patients awaiting SOT or HSCT face the dilemma choosing between life-saving treatment that presents significant threat COVID-19 waitlist dropout, progression disease, mortality. The lack established literature on complicates issue as patients, particularly those with inadequate health...
Abstract Therapeutic plasma exchange (TPE) and continuous kidney replacement therapy (CKRT) are extracorporeal therapeutic procedures often implemented in management of patients. Critically ill patients may be afflicted with disease processes that require both TPE CKRT. Performing discontinuous CKRT is technically easier, however, it disrupts compromise efficiency or hemofilter life. Concurrent offers several advantages including simultaneous control process correction electrolyte, fluid,...
We describe a challenging case of hepatic hydrothorax secondary to nonalcoholic steatohepatitis cirrhosis. Our management involved successfully treating the with transjugular intrahepatic porto-systemic shunt but having manage subsequent complication encephalopathy. conclude review available literature.
Abstract Introduction The clinical efficacy of chimeric antigen and T cell receptor (TCR) immunotherapies is attributed to their ability proliferate persist in vivo. Since the interaction engineered cells with targeted tumour or its environment might suppress function, functionality should be characterized not only before but also after adoptive transfer. Materials methods We sought achieve this by adapting a recently developed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Inflammasome is linked to many inflammatory diseases, including COVID-19 and autoimmune liver diseases. While severe was reported exacerbate failure, we report a fatal acute-on-chronic failure (ACLF) in stable primary biliary cholangitis-autoimmune hepatitis overlap syndrome patient triggered by mild infection. Postmortem biopsy showed sparse SARS-CoV-2-infected macrophages with extensive ASC (apoptosis-associated speck-like protein containing CARD) speck-positive hepatocytes, correlating...
Introduction Chronic Hepatitis B (CHB) remains important health concern in Singapore with approximately 3.6% population affected and common condition requiring follow-up by Gastroenterologist. Virtual monitoring has been used at many centres for various diseases, however, safety, effectiveness is still not explored. Aim Assess if virtual of patients CHB safe, acceptable cost-effective. Methods Prospective randomised-control trial to assess the efficacy patient satisfaction liver tests...
Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection.Our study aims to assess the epidemiology dermatologic conditions among liver in an academic medical center Singapore.Medical records on follow-up with gastroenterology dermatology departments Singapore General Hospital between 2006 2021 were retrospectively reviewed. A literature review was subsequently performed keywords "liver transplant" "dermatology."A...