A5051870090- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Microwave Engineering and Waveguides
- Antenna Design and Optimization
- Infective Endocarditis Diagnosis and Management
- Antenna Design and Analysis
- Congenital Heart Disease Studies
- Spacecraft Design and Technology
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Platelet Disorders and Treatments
- Infectious Aortic and Vascular Conditions
- Venous Thromboembolism Diagnosis and Management
- Satellite Communication Systems
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Advanced Antenna and Metasurface Technologies
- RFID technology advancements
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Surgical site infection prevention
Toho University
2025
Toho University Omori Medical Center
2025
Tokyo Medical and Dental University
2015-2024
Fujita Health University
2022-2024
The University of Tokyo
2018-2024
Fujita Health University Hospital
2023
Fujifilm (Japan)
2023
Tokyo Medical and Dental University Hospital
2014-2022
Heiwa (Japan)
2021
Juntendo University
2004-2019
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes that restricted by major histocompatibility complex-related molecule 1 (MR1). In this study, we investigated the role MAIT in pathogenesis lupus FcγRIIb-/-Yaa mice, spontaneous animal model lupus. Using two approaches cell deficiency, MR1 knockout animals and newly synthesized inhibitory ligand, demonstrate augment disease course enhancing autoantibody production tissue inflammation. deficiency reduced...
Left atrial mitral valve chorda (LAMVC) is a rare congenital cardiac anomaly. The abnormal tissue band, like chorda, attached to the left wall on one side and mostly leaflet other band sometimes disturbs motion, followed by regurgitation (MR). We encountered case with LAMVC which originated from papillary muscle posterior annulus over caused MR due restricted motion.
Recent studies have revealed that the platelet adhesive process under flow is tightly regulated by multiple ligand-receptor interactions. However, morphological changes during this process, particularly its physiological relevance, remain unknown blood conditions. Using epifluorescence and scanning electron microscopy, we evaluated real-time in morphology a on von Willebrand factor-coated surface high shear perfusion chamber. Here, show dynamic shape occurring distinct phases of are...
Background— After a myocardial infarction, the injured region becomes fibrotic and scar may expand if ventricular wall lacks elasticity. Cardiac dilatation precipitate vicious cycle of progressive heart failure. The present study evaluated functional benefits increasing elastin within using cell based gene therapy. Methods Results— A infarction was generated by ligation left anterior descending artery in rats. Six days later, 2×10 6 syngeneic rat endothelial cells transfected with (elastin...
Despite steadily improving outcomes, surgery for acute type A aortic dissection has several unresolved problems such as expansion of the residual false lumen in descending aorta. We performed transaortic stented graft implantation into aorta combined with ascending and arch replacement dissection. review efficacy outcomes this procedure respect to postoperative neurologic complications we encountered.Nine consecutive patients underwent procedure. The elephant trunk was implanted through...
Ventricular dilation after myocardial infarction can cause heart failure. Increasing strength and elasticity in the infarct region might prevent ventricular dilation. Because elastin provides strength, extensibility, resilience to tissues maintains tissue architecture, we studied effect of expression on scar expansion function. COS-7 cells transfected with a plasmid an gene fragment or vector were seeded into Gelfoam mesh cultured. Mechanical stretch test (n = 5/group) showed that was more...
Abstract The aim of the study was to evaluate disposition plasma unbound cefazolin in patients undergoing cardiothoracic surgery with cardiopulmonary bypass ( CPB ). Adult were enrolled study. Cefazolin sodium given intravenously before skin incision (1 g) and at beginning (2 g). Thereafter, an additional dose every 4 hours. Seven ten blood samples collected during surgery. Plasma total (ultrafiltrated) concentrations analyzed using HPLC ‐ UV method. protein binding Langmuir model....
Information on immune checkpoint inhibitor-induced vasculitides is limited, and predictors for this condition have not been identified. Therefore, we examined the frequency of by analyzing data recorded in Japanese Adverse Drug Event Report database. Data from April 2004 to March 2020 were extracted, as an immune-related adverse event was defined according 2012 revised International Chapel Hill Consensus Conference Nomenclature Vasculitides. signals recognized significant when reporting odds...
After restrictive mitral annuloplasty (RMAP) for functional regurgitation (MR), the MR frequently recurs. Papillary muscle relocation (PMR) should reduce recurrence rate. We assessed influence of procedural differences in PMR on postoperative valve configuration. Thirty-nine patients who underwent repair were enrolled. In limited tethering cases, RMAP alone was performed (RMAP group; n = 23). severe addition to RMAP, bilateral papillary muscles relocated direction posterior annulus...
Abstract: A magnetically levitated (MagLev) centrifugal blood pump (CBP) with a disposable head has been designed to realize safe, easy‐to‐handle, reliable, and low‐cost extracorporeal system. It consisted of radial magnetic‐coupled driver magnetic bearing having two‐degree freedom control unit priming volume 24 mL. The easy on–off was made into three‐piece system consisting the top bottom housings, impeller‐rotor assembly. size weight were 75 mm × 45 100 g, respectively. Because structure...
Abstract OBJECTIVES There are few reports on the rotational position of aortic valve relative to base left ventricle, and its influence valve-sparing root replacement (VSRR) has not been reported. Based our experience with complications such as right atrial perforation tricuspid injury, we investigated cause these in terms morphological variations surrounding structures. METHODS The rotation ventricle was assessed 30 patients tri-leaflet valves who underwent VSRR. anatomical surgical...
The risk factors for residual liver recurrence after resection of colorectal cancer metastases were analyzed separately synchronous and metachronous metastases. This retrospective study included 236 patients (139 with 97 lesions) who underwent initial surgery from April 2010 to December 2021 at the Fujita Health University Hospital. We performed univariate multivariate analyses based on clinical background. Univariate analysis identified three factors: positive lymph nodes (p = 0.018, HR...
Abstract Complications due to pump thrombus remain the weak point of mechanical circulatory support (MCS), such as use a left ventricular assist device (LVAD) or extracorporeal membrane oxygenation, leading poor outcomes. Hyperspectral imaging (HSI) is an effective method using hyperspectral (HS) camera, which comprises spectrophotometer and charge‐coupled camera discriminate from whole blood. Animal experiments were conducted analyze dynamic inside prototype hydrodynamically levitated...
Despite a negative Allen test, some patients develop hand ischemia after radial artery harvesting. The presence of large interosseous collaterals may reduce the sensitivity test. To evaluate combination ulnar flow measurements and test as an effective screening technique, we performed Doppler ultrasonography during Allen's maneuver.The was used to select candidates for harvesting from 80 undergoing coronary bypass surgery.Of 71 with one patient developed ischemia. This six (7.5 %) possessing...
We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set driver unit The incident light at near-infrared wavelength 810 nm was aimed pivot bearing, and resulting scattered guided to fibers. detected signal analyzed obtain formation level. As result, real-time monitoring...