Abstract In this study, mean cell volume (MCV), hemoglobin concentration (MCHC), and (MCH) were measured to quantify RBC damage by rotary blood pumps. Six‐hour hemolysis tests conducted with a Bio‐pump BPX‐80, Sarns 15200 roller pump, prototype mag‐lev centrifugal pump (MedTech Heart) using fresh porcine circulated at 5 L/min against 100 mm Hg head pressure. The temperature of the test noncirculated control was maintained 37°C. normalized index (NIH) each determined measuring plasma‐free...

A magnetic fluid seal enables mechanical contact-free rotation of a shaft without frictional heat and material wear hence has excellent durability. However, the durability decreases in liquid. The life applied to rotary blood pump is not known. We have developed that shield mechanism minimizing influence on fluid. worked for over 286 days continuous flow condition, 24 (on-going) pulsatile condition h (electively terminated) flow. promising as pumps.

Abstract: In this study, mechanical trauma to red blood cells was evaluated by conventional hemolysis test and a newly developed cyclically reversing shear flow generator. The fresh porcine obtained from local slaughterhouse subjected the using commercial centrifugal pump for duration of 8 h. measurements consisted (i) plasma‐free hemoglobin based on standard optical measurement (ii) deformability (RBCs) generator microscope image acquisition system. RBCs expressed L/W value where L W were...

Abstract We have evaluated the feasibility of a newly developed single‐use, magnetically levitated centrifugal blood pump, M ed T ech ag‐ L ev, in 3‐week extracorporeal membrane oxygenation ( ECMO ) study calves against edtronic B io‐ P ump BPX ‐80. A heparin‐ and silicone‐coated polypropylene oxygenator MERA NHP E xcelung NSH ‐ R was employed as an oxygenator. Six healthy male H olstein with body weights about 100 kg were divided into two groups, four group group. Under general anesthesia,...

Blood coagulation is one of the primary concerns when using mechanical circulatory support devices such as blood pumps. Noninvasive detection and imaging thrombus formation useful not only for development more hemocompatible but also management to avoid risk infarction. The objective this study investigate use near-infrared light in a rotary pump. optical properties at wavelengths ranging from 600 750 nm were analyzed hyperspectral (HSI) system. A specially designed hydrodynamically...

Optical properties of flowing blood were analyzed using a photon-cell interactive Monte Carlo (pciMC) model with the physical red cells (RBCs) such as cell size, shape, refractive index, distribution, and orientation parameters. The scattering light by at He-Ne laser wavelength 632.8 nm was significantly affected shear rate. scattered more in direction flow rate increased. Therefore, intensity transmitted forward perpendicular to axis decreased. pciMC can duplicate changes photon propagation...

Abstract Plasma skimming is a phenomenon in which discharge hematocrit lower than feed microvessels. has been investigated at bearing gap spiral groove (SGB), as this the potential to prevent hemolysis SGB of blood pump. However, it not clear whether plasma occurs pump with SGB, because obtained. The purpose study verify an centrifugal by developing measurement method SGB. Erythrocyte observation using high‐speed microscope and laser confocal displacement meter was performed five times. In...

Abstract Complications due to pump thrombus remain the weak point of mechanical circulatory support (MCS), such as use a left ventricular assist device (LVAD) or extracorporeal membrane oxygenation, leading poor outcomes. Hyperspectral imaging (HSI) is an effective method using hyperspectral (HS) camera, which comprises spectrophotometer and charge‐coupled camera discriminate from whole blood. Animal experiments were conducted analyze dynamic inside prototype hydrodynamically levitated...

Abstract The purpose of this study is to evaluate a spiral groove geometry for thrust bearing improve the hemolysis level in hydrodynamically levitated centrifugal blood pump. We compared three geometric models: (i) width same as ridge at any given polar coordinate (conventional model); (ii) contracts inward from 9.7 0.5 mm (contraction and (iii) expands 4.2 (expansion model). To level, an impeller levitation performance test vitro were conducted using mock circulation loop. In these tests,...

Abstract The metabolic process in red blood cells (RBCs) is anaerobic. life‐dependent adenosine triphosphate (ATP) for survival of produced through glycolytic process. aim the study was to evaluate effects glucose level on mean corpuscular volume, hemoglobin concentration, and hemolysis rate during by rotary pumps. shear stress generated pumps may enhance utilization RBCs with depletion affecting ATP production and, consequently, cell size, shape, morphology. increases metabolism consuming...

Abstract Pediatric patients with end‐stage heart failure require mechanical circulatory support (MCS) just as adults do. In order to meet the special requirements for neonates' and infants' MCS, pediatric devices must be compact low priming volume, easily controllable flow, less traumatic blood cells tissues, biocompatible minimum anticoagulation. We have designed developed a miniature rotary centrifugal pump, “TinyPump,” volume of 5 mL, which has already demonstrated its performance flow...

We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set driver unit The incident light at near-infrared wavelength 810 nm was aimed pivot bearing, and resulting scattered guided to fibers. detected signal analyzed obtain formation level. As result, real-time monitoring...

Abstract Understanding the thrombus formation in cardiovascular devices such as rotary blood pumps is most important issue developing more hemocompatible devices. The objective of this study was to develop a hyperspectral imaging ( HSI ) method visualize growth process within pump and investigate optical properties thrombus. An vitro thrombogenic test conducted using fresh porcine specially designed hydrodynamically levitated centrifugal with transparent bottom. rotating at 3000 rpm...

Abstract The effect of the flow path geometry impeller on lift‐off and tilt rotational axis against hydrodynamic force was investigated in a centrifugal blood pump with an supported by single‐contact pivot bearing. Four types were compared: FR model having both front rear cutouts tip, F only cutout, R N straight path. First, axial thrust movement about point, which loaded surface impeller, calculated using computational fluid dynamics (CFD) analysis. Next, point measured experimentally. CFD...

Increased extravascular lung water during ex vivo perfusion (EVLP) is associated with ischemia reperfusion injury and poor pulmonary function. A non-invasive technique for evaluating EVLP desired to assess the transplant suitability of lungs. We investigated real-time weight measurements as a reliable method assessing functions in cellular using porcine model.

Abstract The use of contactless support technology for the impeller has led to an increase in durability ventricular assist devices (VADs), and these have been clinical worldwide. However, pump thrombosis stroke are still issues be solved. We developed a method detecting magnetically levitated blood without need additional sensors or other equipment. In proposed method, sinusoidal current is applied electromagnets used magnetic bearing, resulting vibration impeller. phase difference between...

Introduction: Real-time, non-invasive monitoring of thrombus formation in extracorporeal circuits has yet to be achieved. To address the challenges conventional optical detection methods requiring large devices that limit capacity, we developed a micro-optical sensor. Methods: The proposed sensor can detect intensity light scattered by blood at wavelengths 660 and 855 nm. Two sensors were installed on vitro circuit: one rotary pump flow channel. evaluate variation ratio incident each...

Abstract In this study, we have analyzed the changes in mean corpuscular volume (MCV), hemoglobin concentration (MCHC), and dynamic deformability mechanical fragility of red blood cells (RBCs) five male Holstein calves (body weight: 95.6 ± 10.8 kg) whose circulation was partially supported with a novel magnetically levitated extracorporeal centrifugal pump MedTech Dispo. One hour after pumping has started, MCV increased MCHC decreased by 1.064 0.006 0.906 0.050 times, respectively, as...

A photon-cell interactive Monte Carlo (pciMC) that tracks photon migration in both the extra- and intracellular spaces is developed without using macroscopic scattering phase functions anisotropy factors, as required for conventional Carlos (MCs). The interaction of photons at plasma-cell boundary randomly oriented 3-D biconcave red blood cells (RBCs) modeled geometric optics. pciMC incorporates different velocities from to space, whereas MC treats RBCs points space with a constant velocity....

The feasibility of optical non-invasive evaluation the graft function vascular anastomosis was investigated in vitro using hyperspectral imaging (HSI) wavelength range from 500 to 600 nm. A Y-shaped vessel made porcine carotid arteries having an inner diameter 3.5 4 mm. anastomosed at a 45° angle with 8-0 polypropylene suture. Fresh blood oxygen saturation 100% circulated specially designed circuit loop and through or main vessel. vessels were then irradiated light, reflected light captured...

We developed a hyperspectral imaging (HSI) method to image rotary blood pump rotating at high speed, and we investigated the optical properties of associated with clotting. In vitro antithrombogenic testing was conducted. Fresh porcine circulated by hydrodynamically levitated centrifugal while light pulsed same frequency as rotational speed illuminated bottom surface pump. Back scattering captured an HSI camera, spectral in wavelength range from 608 752 nm constructed. area suspected...