Despite decades of technological advancements in blood-contacting medical devices, complications related to shear flow-induced blood trauma are still frequently observed clinic. Blood includes haemolysis, platelet activation, and degradation High Molecular Weight von Willebrand Factor (HMW vWF) multimers, all which dependent on the exposure time magnitude stress. Specifically, accumulating evidence supports that when is exposed stresses above a certain threshold, ensues; however, it remains...

Abstract: In this study, mechanical trauma to red blood cells was evaluated by conventional hemolysis test and a newly developed cyclically reversing shear flow generator. The fresh porcine obtained from local slaughterhouse subjected the using commercial centrifugal pump for duration of 8 h. measurements consisted (i) plasma‐free hemoglobin based on standard optical measurement (ii) deformability (RBCs) generator microscope image acquisition system. RBCs expressed L/W value where L W were...

Although both the erythrocyte sedimentation rate (ESR) and optically measured aggregation parameters are affected by hematocrit, this interaction is not considered method used to estimate ESR that considers parameters. In study, we investigated relationship between obtained Westergren with an parameter, namely, index (AI) of multiple hematocrit values fibrinogen-spiked samples analysis time 5-60 s, attempted develop a rapid accurate estimation method. The AIs from 5- 10-s optical...

Abstract. ULF/ELF emission observation has been performed at Nakatsugawa observatory (geographic coordinates; 35.4° N, 137.5° E, Gifu prefecture) since January 1999. The equipment consists of three-orthogonal magnetic sensors (induction coils), amplifiers, A/D converters and the data logger with a computer. frequency range is from 0.001 Hz to 50 Hz. serious changes in ELF field intensity were detected on 20 September 1999, such way that noise level found increase by more than 5 dB normal for...

Abstract: We have developed a tiny rotary centrifugal blood pump for the purpose of supporting circulation children and infants. The is designed to provide flow 0.1–4.0 L/min against head pressure 50–120 mm Hg. diameter impeller 30 with six straight vanes. supported by hydrodynamic bearing at its center rotated radial coupled magnetic driver. that supports rotation very critical achieve durability, clot‐free antihemolytic performance. In this study, computational fluid dynamics (CFD)...

Abstract A survey of the birth prevalence congenital anomalies among newborn infants in Japan is under way at a large maternity hospital Tokyo. Of 14,430 consecutive babies (7,455 M; 6,975 F), 33 had multiple (MCA) syndrome. These included 2 with trisomy 13 (including mosaic), 3 18 1 16 21 cri‐du‐chat syndrome, 5p partial trisomy, Hallermann‐Streiff Treacher‐Collins achondroplasia, arthrogryposis multiplex congenita, hemihypertrophy, Wiedemann‐Beckwith asplenia Klippel‐Trenaunay‐Weber and...

Abstract Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates generated in LVAD causes impaired platelet aggregation, which increases risk bleeding. The effect rate on formation size aggregates has never been reported experimentally, although aggregation can be considered to directly relevant complications. Therefore, this study investigated impact and exposure time aggregates, vital predicting patients with an...

Our previous study confirmed that not only force but also the catheter contact angle substantially impacted area and its morphology. Therefore, in this study, we aimed to further investigate relationship between dimensions of ablation lesion as a function radiofrequency ablation.The test was performed for 5 angles 8 forces at fixed time 30 s. The initial impedance 92.5 ± 2.5 Ω, temperature during °C, power W. irrigation rate set 17 mL/min. Each experiment repeated 6 times.The showed strong...

Abstract Background Determination of the erythrocyte sedimentation rate (ESR) by measurement aggregation is an alternative to Westergren method and can be performed rapidly. However, its principle opaque ESR values obtained deviate from (WG ESR) due hematocrit. Furthermore, WG affected particle size, but no studies have examined effect individual mean corpuscular volumes (MCVs). Methods Simultaneous index (AI) over a 5‐s interval determination complete blood count in 80 μL 203 patients were...

Obesity has been increasing worldwide and is well-known as a risk factor for cognitive decline. It reported that oxidative stress in the brain deeply involved dysfunction rodent models. While there are many studies on oxidation liver adipose tissue of obese mice, relationship between obesity-induced not elucidated. Here, we show obesity induced by high-fat, high-sucrose diet (HFSD) alters function C57BL/6 male it may involve acceleration oxidation. Tocotrienols (T3s), which members vitamin E...

In chronic inflammatory diseases of the airways, such as cystic fibrosis, hypochlorous acid (HOCl) generated by neutrophils is involved in airway injury. We examined effects HOCl on 16HBE14o– bronchial epithelial cells bolus addition or generation with glucose oxidase plus myeloperoxidase. produced both carbonyl formation a discreet number proteins and modification surface targets that were recognized an antibody raised against HOCl-modified protein. Bolus enzymatically decreased...

Micromixing is a key process in microfluidics technology. However, rapid and efficient fluid mixing difficult to achieve inside the microchannels due unfavourable laminar flow. Active micromixers employing ultrasound thermal energy are effective enhancing micromixing process; however, integration of these sources within devices non-trivial task. In this study, have been extraneously applied at upstream micromixer significantly reduce fabrication complexity. A novel Dean was laser-fabricated...

The authors are developing a prototype of neuro-fuzzy cooperation system that has the precision and learning ability neural network is easy to understand like fuzzy model. To help convert between systems, this with structure corresponding Knowledge acquired from experts was converted network. applied target learned data obtained during operation enhance accuracy Converting back into model helps explain inner representation will be constructed as basic rules improved step by using repetition...

We synthesized a series of neoechinulin A derivatives and examined the structure-activity relationships in terms their anti-nitration anti-oxidant activities as well cytoprotective activity against peroxynitrite from SIN-1 (3-(4-morpholinyl)sydnonimine hydrochloride) using PC12 cells. Our results showed that C-8/C-9 double bond, which constitutes conjugate system with indole diketopiperazine moieties is essential for protection cytotoxicity. The presence an intact moiety additional...

Red blood cells (RBCs) suspended in a dextran solution were at first loaded with uniform shear stress of 21, 43 and 64 Pa for the duration 0, 10, 20, 30, 45 60 min, respectively, followed measurement dynamic deformation terms stretching recovery, using cyclically reversing sinusoidal flow peak 128 2 Hz. The L/W value, where L W major minor axis length RBC images, was derived to compare effects level exposure time. 21 as long min caused statistically insignificant change comparison control...

To elucidate development of shear-induced damage in erythrocytes, it is necessary to visualize erythrocytes under high-shear flow. Therefore, we prototyped a special shear flow chamber with counter-rotating mechanism consisting transparent acrylic cone and glass plate. The was mounted on an inverted microscope illuminated by 350-W metal halide lamp. This experimental system made possible for digital video camera record through the microscopes’ objective lens rheological behavior diluted...