Coen K.M. Boerhout
A5038693008- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- High Entropy Alloys Studies
- Childhood Cancer Survivors' Quality of Life
- Infrared Thermography in Medicine
- Reproductive Health and Contraception
- Transplantation: Methods and Outcomes
- Advanced Materials Characterization Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
Amsterdam University Medical Centers
2021-2025
Amsterdam Neuroscience
2022-2024
University of Amsterdam
2022-2023
Museum Boerhaave
2022
Amsterdam UMC Location University of Amsterdam
2021-2022
The aim of this study was to compare Doppler flow velocity and thermodilution-derived indexes determine the optimal thermodilution-based diagnostic thresholds for coronary reserve (CFR). majority clinical data flow-based are derived from measurements, correspondence with indices remain unclear. An international multicenter registry conducted among patients who had measurements using both thermodilution techniques in same vessel during procedure. Physiological 250 vessels (in 149 patients)...
The microvascular resistance reserve (MRR) was introduced as a means to characterize the vasodilator capacity of coronary microcirculation while accounting for influence concomitant epicardial disease and impact administration potent vasodilators on aortic pressure. This study aimed evaluate diagnostic prognostic performance MRR.A total 1481 patients with stable symptoms clinical indication angiography were included from global ILIAS Registry. MRR derived function flow (CFR) divided by...
Background In the absence of obstructive coronary stenoses, abnormality noninvasive stress tests (NIT) in patients with chronic syndromes may indicate myocardial ischemia nonobstructive arteries (INOCA). The differential prognosis INOCA according to presence microvascular dysfunction (CMD) and incremental prognostic value CMD intracoronary physiologic assessment on top NIT information remains unknown. Methods Results From international multicenter registry (ILIAS [Inclusive Invasive...
Coronary function testing in patients with ischemia and nonobstructive coronary arteries (INOCA) commonly includes assessment of adenosine-mediated vasodilation acetylcholine spasm provocation. The purpose this study was to evaluate the diagnostic value additional endothelial for diagnosis vasomotor dysfunction INOCA.In retrospective cohort study, we included INOCA who underwent clinically indicated comprehensive testing. Endothelial defined as a <50% increase blood flow, determined by...
Angina with non-obstructive coronary arteries (ANOCA) is a major cause of chronic syndromes, affecting nearly half patients anginal symptoms who undergo invasive angiography. ANOCA may lead to substantial symptom burden, increased risk adverse cardiac events, healthcare utilization due ongoing symptoms, repeat hospitalizations, and testing. The pathophysiology often involves variety disorders, such as microvascular dysfunction, epicardial or vasospasm endothelial dysfunction. While function...
Coronary endothelial dysfunction (CED) and coronary artery spasm (CAS) are causes of angina in patients with no obstructive arteries (ANOCA). Both can be diagnosed by invasive function testing (ICFT) using Acetylcholine (ACh). This study aimed to evaluate the diagnostic yield a 3-minute ACh infusion as compared 1-minute bolus injection protocol CED CAS. In total 220 consecutive ANOCA underwent ICFT continuous Doppler flow measurements. Per protocol, 110 were tested thereafter injections, due...
The hyperaemic stenosis resistance (HSR) index was introduced to provide a more comprehensive indicator of the haemodynamic severity coronary lesion. HSR combines both pressure drop across lesion and flow through it. As such, overcomes limitations traditional fractional reserve (FFR) or (CFR) indices.
Intracoronary acetylcholine (ACh) provocation is an established method for diagnosing epicardial and microvascular vasospasm in contemporary clinical practice. We hypothesize that ACh-induced followed by post-spastic reactive hyperemia (PSRH), which measured as increased flow-recovery time. To assess time, indicative of ischemia, among the diagnostic endotypes follow ACh testing. Patients with angina non-obstructive coronary artery disease on angiography who underwent testing were included...
Coronary pressure- and flow-derived parameters have prognostic value. This study aims to investigate the individual combined relevance of pressure flow reflecting resting hyperemic conditions. A total 1,971 vessels deferred from revascularization after invasive assessment were included international multicenter registry. Abnormal defined as distal coronary pressure/aortic ≤0.92 high (1/resting mean transit time >2.4 or average peak >22.7 cm/s), abnormal fractional reserve ≤0.80 low...
BackgroundThe microvascular resistance reserve (MRR) is an innovative index to assess the vasodilatory capacity of coronary circulation while accounting for presence concomitant epicardial disease. The MRR has shown be a valuable diagnostic and prognostic tool in general artery disease (CAD) population. However, considering fundamental aspects its assessment unique hemodynamic characteristics women, it crucial provide additional considerations evaluating specifically women.AimThe aim this...
We assessed the prevalence and diagnostic value of ECG abnormalities for cardiomyopathy surveillance in childhood cancer survivors. In this cross-sectional study, 1381 survivors (≥5 years) from Dutch Childhood Cancer Survivor Study part 2 272 siblings underwent a long-term follow-up echocardiography. compared abnormality prevalences using Minnesota Code between siblings, within biplane left ventricular ejection fraction (LVEF) categories. Among 880 who received anthracycline, mitoxantrone or...
Background Intracoronary physiologic indexes such as coronary flow reserve (CFR) and left ventricular ejection fraction (LVEF) have been regarded prognostic indicators in patients with artery disease. The current study evaluated the association between intracoronary LVEF their differential implications Methods Results A total of 1889 2492 vessels available CFR were selected from an international multicenter prospective registry. Baseline measured by thermodilution or Doppler methods was...
The aim of this study is to evaluate the diagnostic and prognostic value non-hyperaemic Pd/Pa determine its additional when combined with gold standard hyperaemic pressure ratio (FFR) guide revascularization.In a large, multi-center, retrospective registry, we included total 2141 patients clinical indication for coronary angiography providing physiological data in 2726 vessels. A classification was made based on FFR (cut-off value: 0.80) 0.92) values primary outcome target-vessel failure...
Background and aimsThe management of chronic coronary syndrome (CCS) is informed by studies predominantly including men. This study investigated the relationship between patients sex different endotypes CCS, sex-specific clinical outcomes.MethodsIn with CCS undergoing angiography, invasive Fractional Flow Reserve (FFR) Coronary (CFR) were measured. Patients stratified into groups: 1) obstructive artery disease (oCAD) (FFR≤0.80, no revascularization), 2) revascularization, 3) non-obstructive...
Vasoreactivity testing with high-dose acetylcholine is considered vasospasm provocation and low-dose as endothelial function testing.To assess the changes in reaction to low- endotypes of CAS defined by Coronary Vasomotor Disorders International Study Group (COVADIS) working group.Changes coronary epicardial diameter, blood flow (CBF) vascular resistance were determined at acetylcholine.A total 88 ANOCA patients included this analysis. In negative group (n = 14) incremental infusion produced...