A5030121303- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Trauma and Emergency Care Studies
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Psychological Well-being and Life Satisfaction
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Healthcare cost, quality, practices
- Acute Ischemic Stroke Management
- Advanced X-ray and CT Imaging
- Helicobacter pylori-related gastroenterology studies
Amsterdam University Medical Centers
2018-2024
University of Amsterdam
2003-2023
Vrije Universiteit Amsterdam
2019-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2022
Radboud University Nijmegen
2019-2022
Radboud University Medical Center
2019-2022
Amsterdam Neuroscience
2021
Hospital Clínico San Carlos
2015
Medisch Centrum Alkmaar
2007
Amsterdam UMC Location University of Amsterdam
1999-2003
Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role immediate coronary angiography and percutaneous intervention (PCI) in the treatment patients who have been successfully resuscitated after arrest absence ST-segment elevation myocardial infarction (STEMI) remains uncertain.
<h3>Importance</h3> Ischemic heart disease is a common cause of cardiac arrest. However, randomized data on long-term clinical outcomes immediate coronary angiography and percutaneous intervention (PCI) in patients successfully resuscitated from arrest the absence ST segment elevation myocardial infarction (STEMI) are lacking. <h3>Objective</h3> To determine whether improves at 1 year after without signs STEMI, compared with delayed strategy. <h3>Design, Setting, Participants</h3> A...
Early P2Y
A total of 40% to 50% patients with ST-segment-elevation myocardial infarction develop microvascular injury (MVI) despite angiographically successful primary percutaneous coronary intervention (PCI). We investigated whether hyperemic resistance (HMR) immediately after PCI predicts MVI at cardiovascular magnetic resonance and reduced blood flow positron emission tomography (PET).Sixty were included in this prospective study. Immediately PCI, intracoronary pressure-flow measurements performed...
Background: Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, microvascular injury occurs in a large proportion patients ST-segment–elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reported to increase plasma adenosine levels, which might have protective effect on the microcirculation. We investigated whether ticagrelor maintenance therapy after revascularized infarction is...
Patients with acute coronary syndrome who present initially ST-elevation on the electrocardiogram but, subsequently, show complete normalization of ST-segment and relief symptoms before reperfusion therapy are referred to as transient elevation myocardial infarction (STEMI) pose a therapeutic challenge. It is unclear what optimal timing revascularization for these patients whether they should be treated STEMI-like or non-ST-segment (NSTEMI)-like invasive approach. The aim study determine...
OBJECTIVES: Existing scores for risk stratification after out-of-hospital cardiac arrest (OHCA) are either medically outdated, limited to registry data, small cohorts, and certain healthcare systems only, or include rather complex calculations. The objective of this study was develop an easy-to-use prediction score short-term mortality in patients with successfully resuscitated OHCA without ST-segment elevation on the post-resuscitation electrocardiogram, derived from Angiography...
Background Off‐target properties of ticagrelor might reduce microvascular injury and improve clinical outcome in patients with ST‐segment–elevation myocardial infarction. The REDUCE ‐ MVI (Evaluation Microvascular Injury Revascularized Patients ST‐Segment–Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel) trial reported no benefit regarding function at 1 month. We now present the follow‐up data up to 1.5 years. Methods Results randomized 110 infarction either 90 mg...
Concomitant coronary artery disease (CAD) is highly prevalent in patients with severe aortic stenosis undergoing transcatheter valve implantation (TAVI). The optimal treatment strategy for CAD a topic of debate. An initial conservative TAVI may be favorable as multiple studies have failed to show an evident beneficial effect percutaneous intervention (PCI) on mortality after TAVI. However, more randomized, controlled trials are warranted. PeRcutaneous cOronary Intervention before...
In comparison to male patients with coronary artery disease, female suffer from more comorbidities, experience symptoms of disease differently and report poorer health-related quality life (HRQoL) after revascularization. However, there is limited data on the impact comorbidity burden recovery in HRQoL patients. We investigated change following revascularization versus 230 (60 female) were assessed before, two weeks, three months six Disease-specific was measured Short-Form Seattle Angina...
Background: The invasive microvascular function indices, coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR), exhibit a dynamic pattern after ST-segment–elevation myocardial infarction. effects injury on evolution prognostic significance are unknown. We investigated relationship between temporal changes CFR IMR, cardiovascular magnetic resonance-derived characteristics in reperfused infarction patients, their association with 1-month left ventricular ejection...
AimA multimodal approach is advised for neurological prognostication in comatose patients after out-of-hospital cardiac arrest (OHCA). Grey-white matter differentiation (grey-white ratio, GWR) obtained from a brain CT scan performed < 24 hours return of circulation can be part this approach. The aims study were to investigate the frequency and method reporting GWR reports their association with outcome.MethodsThis post-hoc descriptive analysis COACT trial. primary endpoint was by...
Measuring change in health-related quality-of-life (HRQoL) is important to assess the impact of disease and/or treatment. Ecological momentary assessment (EMA) comprises repeated HRQoL natural environment and particularly suited capture daily experiences. Our objective was study whether measures or retrospective are more strongly associated with criterion HRQoL. Twenty-six coronary artery patients completed questionnaires before after revascularization. Momentary assessed 14 items which were...
BackgroundThe effect of immediate coronary angiography and percutaneous intervention (PCI) in patients who are successfully resuscitated after cardiac arrest the absence ST-segment elevation myocardial infarction (STEMI) on left ventricular function is currently unknown.MethodsThis prespecified sub-study a multicentre trial evaluated 552 patients, from out-of-hospital without signs STEMI. Patients were randomized to either undergo or delayed angiography, neurologic recovery. All underwent...
Up to 24% of patients presenting with ST-elevation myocardial infarction (STEMI) show resolution and symptoms before revascularization. The mechanisms spontaneous reperfusion are unclear. Given the more favorable outcome transient STEMI, it is important obtain further insights in differential aspects.We compared 251 who presented STEMI (n = 141) or persistent 110). Clinical angiographic laboratory data were collected at admission subset additional index hemostatic steady-state follow-up....
Objectives. Quantitative flow ratio (QFR) computes fractional reserve (FFR) based on invasive coronary angiography (ICA). Residual QFR estimates post‐percutaneous intervention (PCI) FFR. This study sought to assess the relationship of residual with post-PCI Methods. analysis, using pre-PCI ICA, was attempted in 159 vessels lesion location matched PCI simulate performed and allow computation QFR. A FFR < 0.90 used define a suboptimal result. Results. successful 128 (81%) vessels. Median...
The aims of this study were to investigate (1) the extent which response shift occurs among patients with coronary artery disease (CAD) after revascularization, (2) whether assessment changes in health-related quality life (HRQoL), controlled for shift, yield more valid estimates HRQoL, as indicated by stronger associations criterion measures change, than without controlling and (3) if occurrences are related patient characteristics.Patients CAD completed SF-36 Seattle Angina Questionnaire...