A5066447952- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Multiple Sclerosis Research Studies
- Bariatric Surgery and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and exercise physiology
- Health Systems, Economic Evaluations, Quality of Life
- Takotsubo Cardiomyopathy and Associated Phenomena
- Healthcare Systems and Public Health
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Disease and Adiposity
Haukeland University Hospital
2016-2025
University of Bergen
2006-2023
OLVG
2019
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Background During primary percutaneous coronary intervention (PCI), a concurrent chronic total occlusion (CTO) is found in 10% of patients with ST-elevation myocardial infarction (STEMI). Long-term benefits CTO-PCI have been suggested; however, randomised data are lacking. Our aim was to determine mid-term and long-term clinical outcome versus CTO-No PCI STEMI CTO. Methods The Evaluating Xience left ventricular function on occlusiOns afteR (EXPLORE) multicentre trial that included 302 after...
We aimed to investigate the association between use and findings of IVUS with clinical outcomes in PCI arm a randomised trial LMS PCI.The NOBLE patients disease treatment by or CABG. Of 603 treated PCI, 435 (72%) underwent post-PCI assessment, 224 which were analysed core laboratory. At five years, composite MACCE was 18.9% if performed versus 25.0% it not (p=0.45, after adjustment). Overall repeat revascularisation reduced (10.6% vs 16.5%, p=0.11); however, TLR (5.1% 11.6%, p=0.01) used....
Abstract Aims To assess differences in long-term outcome and functional status of patients with cardiogenic shock (CS) treated by percutaneous mechanical circulatory support (pMCS) intra-aortic balloon pump (IABP). Methods results Long-term follow-up the multicentre, randomized IMPRESS Severe Shock trial (NTR3450) was performed 5-year after initial randomization. Between 2012 2015, a total 48 severe CS from acute myocardial infarction (AMI) ST-segment elevation undergoing immediate...
The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) the concurrent chronic total occlusion (CTO) ST-segment elevation myocardial infarction (STEMI) patients global (LV) systolic function. However possible treatment effect will be most pronounced CTO territory. Therefore, we aimed to study compared no-CTO recovery regional LV function, particularly Using...
The EXPLORE (Evaluating Xience and Left Ventricular Function in PCI on Occlusions After STEMI) trial was the first only randomized investigating chronic total occlusion (CTO) percutaneous coronary intervention (PCI) early after primary for ST-segment-elevation myocardial infarction, compared with medical therapy CTO. We performed a 10-year follow-up of to investigate long-term safety clinical impact CTO no-CTO PCI.
Saeed, Sahrai; Eriksen, Erlend; Aukrust, Pål; Halvorsen, Bente; Løland, Kjetil; Bleie, Øyvind; Bogale, Nigussie Author Information
Objectives The primary objectives were to identify the predictors of new permanent pacemaker implantation in patients with aortic stenosis (AS) undergoing transcatheter valve (TAVI). secondary investigate temporal changes following TAVI and its impact on long-term prognosis. Design Prospective observational cohort study AS TAVI. Setting Single-centre conducted at a tertiary hospital Western Norway between 2012 2019. Participants Among 600 consecutive severe who treated TAVI, 52 prior...
Global left ventricular (LV) function is routinely used to assess cardiac function; however, myocardial strain able identify more subtle dysfunction. We aimed determine the recovery and prognostic value of featuring tracking (FT) cardiovascular magnetic resonance (CMR) in ST-segment elevation infarction (STEMI) patients with a concurrent chronic total occlusion (CTO). In randomized EXPLORE trial, there was no significant difference global LV after percutaneous coronary intervention (PCI)...
Objective The impact on cardiac function of collaterals towards a concomitant chronic total coronary occlusion (CTO) in patients with ST-elevation myocardial infarction (STEMI) has not been investigated yet. Therefore, we have evaluated the well-developed compared poorly developed to CTO STEMI. Methods and results In EXPLORE trial, STEMI were randomised either percutaneous intervention (PCI) or no-CTO PCI. Collateral grades scored angiographically using Rentrop grade classification. Left...
Abstract The right ventricle (RV) is frequently involved in ST-segment elevation myocardial infarction (STEMI) when the culprit or concurrent chronic total occlusion (CTO) located coronary artery (RCA). We investigated RV function recovery STEMI-patients with CTO. In EXPLORE, CTO were randomized to percutaneous intervention (PCI) no CTO-PCI. analyzed 174 EXPLORE patients serial cardiovascular magnetic resonance imaging data (baseline and 4-month follow-up), divided into three groups: CTO-RCA...
ST elevation myocardial infarction (STEMI) is caused by an occlusive thrombosis of a coronary artery. We wanted to assess if the thrombus can be characterized according erythrocyte content and age using intravascular optical coherence tomography (OCT) in clinical setting.We performed manual aspiration 66 STEMI patients. OCT was done remnants after aspiration. A light intensity ratio measured through thrombus. Forty two aspirates had which could analyzed histomorphologically for analysis...
`To analyze the impact of additional coronary artery disease, quantified by SYNTAX (SYNergy between PCI with TAXus and cardiac surgery) score, on left ventricular ejection fraction (LVEF) long-term outcomes in a cohort ST-elevated myocardial infarction (STEMI) patients concomitant chronic total occlusion (CTO). A 302 STEMI were randomized to percutaneous intervention CTO (CTO PCI) (n = 148) or conservative treatment 154). scores calculated an independent corelab (Cardialysis BV, Rotterdam)...
Abstract Background Aortic stenosis (AS) is a progressive disease, which untreated leads to irreversible myocardial damage and potentially death. Patients with AS may present acute decompensation (ADAS) even during active surveillance. Purpose In this TAVI-NOR sub-study, we investigate the clinical profile, risk factors, epidemiology long-term outcomes of patients treated TAVI after presenting ADAS compared stable who underwent elective (no ADAS). Method A total 600 severe consecutively...
Abstract Objectives To assess the effect of chronic total occlusion percutaneous coronary intervention (CTO PCI) on ventricular ectopy (VE) and symptomatology during exercise testing. Background During exercise, hypoxic myocardium in CTO‐territory can act as a substrate for VE could lead to anginal complaints. Methods In EXPLORE‐trial, 302 ST‐segment elevation myocardial infarction (STEMI)‐patients were randomized CTO PCI or no‐CTO PCI. For this sub‐study, we analyzed all available...
Abstract Objective To evaluate predictors of procedural success percutaneous coronary intervention (PCI) chronic total occlusions (CTOs) in a non‐infarct‐related artery following ST‐segment elevation myocardial infarction (STEMI), and demonstrate the effect on left ventricular functionality (LVF), infarct size (IS), pro‐arrhythmic electrocardiogram (ECG) parameters. Background Predictors unsuccessful revascularization CTO are numerous, although STEMI, these lacking. Besides, effects failed...