A5010172807- Health disparities and outcomes
- Obesity, Physical Activity, Diet
- Asthma and respiratory diseases
- Sleep and Wakefulness Research
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Obstructive Sleep Apnea Research
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Workplace Health and Well-being
- Noise Effects and Management
- Sleep and related disorders
- Dementia and Cognitive Impairment Research
- Employment and Welfare Studies
- Allergic Rhinitis and Sensitization
- Birth, Development, and Health
- Neutropenia and Cancer Infections
- Behavioral Health and Interventions
- Physical Activity and Health
- Childhood Cancer Survivors' Quality of Life
- Alzheimer's disease research and treatments
- Pediatric health and respiratory diseases
University of Helsinki
2016-2025
University of Turku
2004-2025
Helsinki University Hospital
2016-2025
Turku University Hospital
2003-2025
Pediatrics and Genetics
2011
Turku PET Centre
2002-2011
Institute for Molecular Medicine Finland
1992-2011
Åbo Akademi University
2011
Folkhälsans Forskningscentrum
2010
Stanford University
2009
Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair EC (PAEC) function. This adversely affect survival and promote SMC proliferation. We hypothesized that interventions to normalize of genes are targets BMPR2 signaling could restore PAEC function prevent or reverse PAH. Here we have characterized, human PAECs, a BMPR2-mediated transcriptional complex between PPARγ β-catenin shown disruption this impaired...
Abstract The persistence of rhinovirus and enterovirus RNAs was studied in the nasal secretions children with acute expiratory wheezing (median age: 1.7 years). On admission, 84 samples from 161 (52%) admitted to hospital were positive by reverse transcriptase‐polymerase chain reaction (RT‐PCR), which detects rhino‐ enteroviruses simultaneously. Of samples, 26 (16%) for rhinovirus, 29 (18%) nontypable rhino‐enterovirus. After 2 weeks, 16 these (19%) still positive. Rhinovirus RNA remained 13...
Background. Inability to maintain balance while standing increases risk of falls in older people. The present study assessed whether center pressure (COP) movement measured with force platform technology predicts for among people no manifest deficiency balance.
We report the association between hostility and incidence of ischemic heart disease (IHD) in 3,750 Finnish men aged 40-59. Hostility was assessed from self-ratings on irritability, ease anger-arousal, argumentativeness, four groups were formed summed ratings. At baseline, age-adjusted relative risk (RR) prevalence angina pectoris highest lowest 2.88 (95% confidence limits (CL), range 1.71-4.77). A three-year follow-up yielded 65 deaths 109 IHD-incident cases. did not predict IHD among...
OBJECTIVE--To investigate the risk of cancer in children living close to overhead power lines with magnetic fields > or = 0.01 microteslas (microT). DESIGN--Cohort study. SETTING--The whole Finland. SUBJECTS--68,300 boys and 66,500 girls aged 0-19 years during 1970-89 within 500 m 110-400 kV calculated be microT. Subjects were identified by record linkages nationwide registers. MAIN OUTCOME MEASURES--Numbers observed cases follow up for standardised incidence ratios all cancers...
The purpose of the present study was to examine, first, whether hearing acuity predicts falls and potential association is explained by postural balance and, second, examine shared genetic or environmental effects underlie these associations. Hearing measured using a clinical audiometer as part Finnish Twin Study on Aging in 103 monozygotic 114 dizygotic female twin pairs aged 63–76 years. Postural indicated center pressure (COP) movement semitandem stance, participants filled fall-calendar...
We studied the inheritance of migraine and concomitant symptoms among 2690 monozygotic (1524 female 1166 male) pairs 5497 dizygotic (2951 2546 twin pairs. Our material consists a population‐based questionnaire study Finnish twins in 1981. The definition is based on method. Concordance was assessed using probandwise concordance rates tetrachoric correlations for (MZ) (DZ) For estimating contribution genetic factors to susceptibility migraine, polygenic multifactorial model used. Structural...
To investigate the prevalence of and factors associated with daytime sleepiness occurring every or almost day.A cross-sectional, questionnaire survey.A total 11,354 adults (aged 33-60 years) representative Finnish population.Frequency sleepiness, naps sleep attacks; occurrence emotion-associated muscle weakness, debt, insomnia, apnoeas type snoring; Beck Depression Inventory score; use hypnotics tranquillisers.A 11.0% women 6.7% men suffered from day. Amongst those (n = 1,026) 19.5% 42.3%...
The prevalence and incidence of asthma in relation to cigarette smoking habits was studied a population 14,729 Finnish adult men women who participated postal health survey 1975. Of those invited participate new 1981, 89.7% replied. Asthma diagnosed on the basis self reporting by physician record linkage national register hospital admissions all general tuberculosis hospitals during 1972 1983. 1975 significantly higher among male smokers than non-smokers (relative risk (RR) = 1.73); no...
Evidence of an association between job strain and obesity is inconsistent, mostly limited to small-scale studies, does not distinguish categories underweight or subclasses.
Abstract Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade the treatment choice for vasculopathy, but often fails to reverse refractory cytopenia. We aimed study...
Background: Epidemiologic data on asthma and allergies among adults are mainly based questionnaires: this study validates the questions asthma, allergic rhinitis, conjunctivitis of a new Finnish questionnaire. Methods: To validate used in country‐wide university students aged 18–25 years, we examined 150 subjects who had ever reported or wheezing, 140 without symptoms. Questions were validated relation to current diseases including 1) symptoms detected during preceding year at physician's...
A strong sense of coherence (SOC) is found to be associated with good mental health. This study investigated (1) whether negative life events affect level SOC, (2) initial SOC modifies the effect on and (3) stability differs between genders. The data were derived from 15‐year Health Social Support ( N = 17,271). Ordinary linear regression analysis was used. Negative decreased among both genders irrespective timing event. more recent event, lower SOC. in 1998 did not protect declining during...
The prevalence of narcolepsy is usually presented at about 50/100,000. There are, however, marked differences 2,500-fold between the lowest and highest reported prevalence. This discrepancy least partly explained by in study populations methods. no earlier populationbased epidemiological studies with polygraphically confirmed diagnoses. We studied occurrence symptoms resembling two main manifestations narcolepsy, i.e. abnormal sleep tendency emotion-associated muscular weakness, an adult...
There is a large body of research on adulthood risk factors for retirement due to disability, but studies the effect adverse childhood experiences are scarce.To examine whether predict disability retirement.Data were derived from Health and Social Support Study. The information was gathered postal surveys in 1998 (baseline) 2003 (follow-up questionnaire). analysed data consisted 8817 non-retired respondents aged 40-54 years (5149 women, 3668 men). Negative experiences, such as financial...
SUMMARY The Ullanlinna Narcolepsy Scale (UNS) is a simple questionnaire‐based method used to measure the symptoms of narcoleptic syndrome. 11‐item scale (range 0–44) assesses two main features syndrome, abnormal sleeping tendency and cataplexy. UNS sum score reliably distinguishes patients with syndrome from sleep apnoea, multiple sclerosis, epilepsy. mean in was 27.3 (95% confidence limits 24.4–33.1); apnoea group 9.6 7.2–12.0) came closest this. Validation data were also selected large...