Knowledge about the volume of collateral flow provides insight into severity coarctation aorta and may be critical in planning operative approach. There is currently no method for quantification aorta. In this study, we applied velocity encoded cine magnetic resonance imaging (VENC-MR) to establish pattern descending thoracic normal subjects patients with coarctation, introducing a new possibility quantify by determining amount flow.VENC-MR was used measure proximal distal 10 subjects. 23...

The interstudy reproducibility of velocity-encoded cine (VEC) magnetic resonance (MR) imaging for quantification regurgitant volume (RV) and fraction (RF) was studied in 10 patients with chronic aortic regurgitation. Each patient underwent two VEC MR studies. RV RF were measured on the flow curve by quantifying antegrade retrograde per cardiac cycle. measurements correlated closely volumetric both studies (r greater than .97). Interstudy measurement high .97), variability low. These results...

Objective An elevated acute-phase response is associated with increased radiologic damage in rheumatoid arthritis (RA), but development of previously normal joints ("new joint involvement") has not been investigated. This study was undertaken to investigate the hypothesis that when there suppression disease activity as judged by C-reactive protein level, new involvement reduced a greater extent than progression already damaged ("damaged progression"). Methods Three hundred fifty-nine...

Velocity-encoded cine magnetic resonance (MR) imaging provides two-dimensional velocity maps of a cross-sectional area vessel. Pulmonary flow and patterns in the main pulmonary artery were analyzed with velocity-encoded MR Doppler echocardiography 10 patients hypertension (PH), one patient dilated artery, healthy subjects, these findings compared. Peak systolic measured was similar to that subjects PH. demonstrated substantial differences across vascular lumen The pattern different than PH;...

Quantification of pulmonary flow is clinically important in the evaluation both congenital and acquired heart disease. Velocity-encoded cine magnetic resonance (MR) a promising technique for measuring velocity volume blood flow. The authors report validation accuracy velocity-encoded MR measurement oblique-angle vitro, with use constant-flow phantom, vivo, nine healthy volunteers whom velocities were measured separately main, right, left arteries. Findings at compared findings Doppler...

To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging.Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded images were acquired at seven to 13 temporal phases in 25 seconds, k-space segmentation and view-sharing reconstruction (+/- 1 m/sec velocity-encoding value) (repetition time msec/echo msec = 16/9). Flow velocity the left anterior descending (LAD) artery was measured twice before after administration of...

Spinal trabecular bone mineral content was measured in the first, second, and third lumbar vertebrae by quantitative computed tomography 88 patients with non-steroid treated rheumatoid arthritis. Results were compared those obtained 105 healthy control subjects. The mean patient group, 135.8 (SD 32.8) mg/ml K2HOP4, significantly lower than that controls (151.9 (32.1) mg/ml, p less 0.01). Division of into three age groups showed reduction most marked youngest group (21-40 years), value male...

OBJECTIVE--To examine whether changes in cancellous bone turnover and resorption cavity depth contribute to loss patients with non-steroid treated rheumatoid arthritis. METHODS--Iliac crest biopsies were obtained from 37 arthritis, 13 male 24 female, aged 37-71 years. Bone characteristics quantitatively assessed using semiautomated computerised techniques. RESULTS--When compared age- sex-matched control values, there was a significant reduction formation rate at tissue level activation...

Technetium labelled, negatively charged, unilamellar liposomes were given by intravenous injection to patients with rheumatoid arthritis and the joints scanned 20-22 hours later. Positive scintigraphy was obtained in all six active disease, and, exception of small interphalangeal joints, clinically involved could be visualised.

Patients with rheumatoid arthritis, psoriatic and osteoarthritis were assessed by clinical evaluation, radiography, joint scintigraphy using technetium labelled methylene diphosphonate (MDP) liposomes. Although both scanning techniques more sensitive than radiographs in detecting disease, the liposomes scans positive only clinically active inflammatory disease. In patients arthritis liposome was also able to discriminate between different grades of tenderness. inactive polyarthropathies,...

Iliac crest trabecular bone volume and structure have been studied in biopsy specimens from 48 patients with classical or definite rheumatoid arthritis, none of whom had received steroids. Results were compared those obtained healthy controls matched for age sex. The mean female aged 34-50 years was significantly lower than (p less 0.01); male values also (mean (SD) 17.8 (3.2) v 22.4 (5.6)% total medullary volume), though this difference not statistically significant. Values older similar to...

OBJECTIVE: To compare the efficacy of hydroxychloroquine, penicillamine, sodium aurothiomalate and auranofin in treatment active rheumatoid arthritis over a period 5 yr. METHOD: Five hundred forty-one patients with definite or classical were entered into an open randomized controlled trial flexible dose regimen designed to reflect clinical practice. Decisions stop any one disease-modifying anti-rheumatic drugs (DMARDs) based on agreed protocol which defined criteria for adverse reactions...

Breath-hold MR cine angiography was used to depict the coronary arteries in healthy volunteers. Multiangle oblique imaging planes were evaluated for feasibility showing continuous segments of proximal and middle portions left anterior descending right arteries.Eighteen subjects examined with a 1.5-T imager. Fat-suppressed fast gradient-echo images (TR = 9.8 msec, TE 3.5 msec) acquired 13-cm receive surface coil. A segmented k-space data acquisition obtain at several phases cardiac cycle...

A case of Cushing's syndrome after long term intra-articular corticosteroid injections is described. Prolonged suppression the hypothalamic-pituitary-adrenal axis occurred as assessed by an insulin tolerance test 11 weeks last injection. Replacement steroid therapy was required.

Achieving hepatitis C virus (HCV) elimination by 2030 requires an increased linkage to care for people who inject drugs (PWID). Project ITTREAT was established mitigate barriers HCV providing integrated service within a local drug and alcohol treatment centre. This study aimed explore the experiences of clients staff involved in assess facilitators community-based service. Between October 2014 April 2016, attendees were interviewed using one-to-one semi-structured interviews. Drug took part...

MR imaging of the myocardium using nonionic contrast medium: signal-intensity changes in patients with subacute myocardial infarction.M C Dulce, A J Duerinckx, Hartiala, G R Caputo, M O'Sullivan, D Cheitlin and B HigginsAudio Available | Share

Journal Article IMMUNOGENETIC HETEROGENEITY IN RHEUMATOID DISEASE AS ILLUSTRATED BY DIFFERENT MHC ASSOCIATIONS (DQ, DW AND C4) ARTICULAR EXTRA-ARTICULAR SUBSETS Get access M. C. HILLARBY, HILLARBY University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford; ARC Epidemiology Research Unit, Manchester; Rheumatology Wrightington Wigan; Staffordshire Stoke-on-Trent and Department Rheumatology, Hospital WalesCardiff Search for other works by this author on: Oxford Academic PubMed...

Objectives. To describe the changes in functional ability (FA) taking place over 5 yr patients with rheumatoid arthritis (RA) starting disease-modifying anti-rheumatic drug (DMARD) therapy, to investigate factors having most influence upon FA and compare these at baseline after of treatment. Methods. Three hundred sixty-six active RA were studied as part a 5-yr randomized controlled study DMARD therapy. was assessed by Health Assessment Questionnaire (HAQ) score every 6 months. Multiple...

A study was designed to establish the reliability of assessing joint tenderness in rheumatoid arthritis. Reliability both within and between observers measured 95% confidence intervals (CI) for a change score calculated. Forty-two patients were assessed by two metrologists over 14-week period using three subjects per week. Results showed close agreement metrologists. The CI repeat measures same metrologist +/- 8.5 12 different metrologist. Taking 5 as clinically significant, significant...

Background and aims Majority of the individuals with hepatitis C virus (HCV) infection in England are people who inject drugs, a vulnerable disenfranchised cohort poor engagement secondary care. Our aim is to describe our experiences setting up successful nurse led HCV service at substance misuse (SMS). Methods We justify need for community review different based models. engaging stakeholders, obtaining funding, set up, challenges faced key recommendations discussed. Finally, summary interim...

Abstract Achieving hepatitic C virus (HCV) elimination requires linking people who use drugs (PWUD) into care. We report final direct‐acting antivirals (DAAs)‐based outcomes from the Integrated‐Test‐stage ‐Treat (ITTREAT) study. Project ITTREAT (2013–2021), based at an addiction centre, was a ‘one‐stop’ service with innovative linkage to care strategies. Primary outcome sustained virological response (SVR12) (intention treat ITT) including whether individuals were recruited in first (period...

We report a case of chronic recurrent multifocal osteomyelitis which presented as back pain in 14-yr-old male. The full distribution the spinal lesions was determined by MRI, proved to be more sensitive than other imaging modalities. After 1 yr, spite good symptomatic response corticosteroid therapy, new MRI abnormalities had developed.