A5084836202- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- TGF-β signaling in diseases
- Pancreatic function and diabetes
- Lung Cancer Research Studies
- Chromatin Remodeling and Cancer
- Kruppel-like factors research
- Protein Kinase Regulation and GTPase Signaling
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Mycotoxins in Agriculture and Food
Shanghai Institute of Nutrition and Health
2019-2024
University of Chinese Academy of Sciences
2019-2024
Second Military Medical University
2021-2024
Eastern Hepatobiliary Surgery Hospital
2021-2024
East China University of Science and Technology
2019-2021
Shanghai Institutes for Biological Sciences
2019
National Vaccine and Serum Institute
2017
Significance In this study, we find that ARID2 expression is negatively correlated with HCC metastasis and positively associated prognosis of patients. We demonstrate inhibits cells by recruiting DNMT1 to the promoter Snail, which elevates DNA methylation suppresses Snail transcription. Notably, discover a C2H2 truncated mutation (3817C > T) in metastatic tissue. further reveal domain required for ARID2–DNMT1 interaction loss-of-function mutants disrupted are poor survival Taken together,...
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic in world, however, no drug treatment been approved for this disease. Thus, it is urgent to find effective therapeutic targets clinical intervention. In study, we that liver-specific knockout of PPDPF (PPDPF-LKO) leads spontaneous formation a mouse model at 32 weeks age on chow diets, which enhanced by HFD. Mechanistic study reveals negatively regulates mTORC1-S6K-SREBP1 signaling. interferes with interaction...
Background and aims The efficacy safety of systemic atezolizumab bevacizumab (atezo/bev) in treatment patients with unresectable hepatocellular carcinoma (HCC) have been demonstrated. However, the this HCC extrahepatic portal vein tumor thrombus (ePVTT) is not satisfactory. This study aimed to combining intensity-modulated radiotherapy (IMRT) atezo/bev these patients. Methods multicenter prospective included ePVTT treated IMRT combined from March September 2021 three centers China. outcomes...
Hepatocellular carcinoma (HCC) is a highly heterogeneous solid tumor with high morbidity and mortality. AT-rich interaction domain 1A (ARID1A) accounts for up to 10% of mutations in liver cancer, however, its role HCC remains controversial, no targeted therapy has been established.The expression ARID1A clinical samples was examined by Western blot immunohistochemical staining. knocked out Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)...
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) has been reported to play a role in tumorigenesis. However, its function hepatocellular carcinoma (HCC) remains poorly understood. In this study, we report that PPDPF is significantly downregulated HCC the decreased expression indicates poor prognosis. dimethylnitrosamine (DEN)-induced mouse model, hepatocyte-specific depletion of Ppdpf promotes hepatocarcinogenesis, reintroduction into liver-specific knockout (LKO)...
The attenuated Japanese encephalitis virus (JEV) strain SA14-14-2 has been successfully utilized to prevent JEV infection; however, the attenuation determinants have not fully elucidated. envelope (E) protein of differs from that virulent parental SA14 at eight amino acid positions (E107, E138, E176, E177, E264, E279, E315, and E439). Here, we investigated SA14-14-2-attenuation by mutating E107, E279 in their status tested replication capacity, neurovirulence, neuroinvasiveness, mortality...
Abstract Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, underlying mechanisms remain largely elusive. In this study, we report that expression choroideremia-like (CHML) increased HCC, associated with survival, early and more satellite nodules HCC patients. CHML promotes migration, invasion metastasis cells, a Rab14-dependent manner. Mechanism study reveals facilitates constant recycling Rab14 by escorting to membrane....
Ochratoxin A(OTA) is considered to be one of the most important contaminants food and feed worldwide. The liver key target organs for OTA exert its toxic effects. Due current lifestyle diet, nonalcoholic fatty disease (NAFLD) has been common disease. To examine potential effect on hepatic lipid metabolism NAFLD, C57BL/6 male mice received 1 mg/kg by gavage daily. Compared with controls, increased deposition TG accumulation in mouse livers. In vitro treatment also promoted droplets primary...
Abstract Objectives Wnt1‐inducible signalling pathway protein 3 (WISP3/CCN6) belongs to the CCN (CYR61/CTGF/NOV) family of proteins, dysregulation this contributed tumorigenicity various tumours. In study, we need explore its role in hepatocellular carcinoma that remains largely elusive. Materials and Methods The expression WISP3/CCN6 was analysed by qRT‐PCR Western blotting. Effects WISP3 on proliferation metastasis HCC cells were examined, respectively, MTT assay Boyden Chamber. Roles...
The role of epithelial V-like antigen 1 (EVA1) has been well studied in thymic development and homostasis; however, its putative relationship with cancer remains largely unknown. Therefore, here we investigated the EVA1 hepatocellular carcinoma. Interestingly, expression was significantly increased carcinoma (HCC) also associated a poor prognosis recurrence HCC patients. Overexpression promoted cell growth, invasion migration vitro. Consistently, knockdown inhibited proliferation vitro,...
Anti-programmed cell death ligand 1/vascular endothelial growth factor inhibition, coupled with chemotherapy, may potentiate antitumor immunity leading to enhanced clinical benefit, but it has not been investigated in advanced biliary tract cancer (BTC).We the efficacy and safety of atezolizumab, bevacizumab, gemcitabine plus oxaliplatin (GEMOX) BTC explore potential biomarkers related response.Multicenter, single-arm, retrospective study.Advanced patients, who received a triple combination...
Metastasis is the main cause of colorectal cancer (CRC)-related death, and 5-year relative survival rate for CRC patients with distant metastasis only 14%. X-linked inhibitor apoptosis (XIAP)-associated factor 1 (XAF1) a zinc-rich protein belonging to interferon (IFN)-induced gene family. Here, we report metastasis-promoting role XAF1 in by acting as novel adaptor valosin-containing (VCP). facilitates VCP-mediated deubiquitination E3 ligase RING finger 114 (RNF114), which promotes K48-linked...
Abstract The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the of GDP for GTP on RAS. However, regulation GEF activity remains elusive. Here, authors report that PPDPF functions as an important regulator SOS1. expression is significantly increased in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and recurrence PDAC patients. Overexpression promotes cell growth vitro vivo, while knockout exerts opposite effects. Pancreatic‐specific deletion profoundly...
Neuroepithelial cell transforming gene 1 (NET1), a member of the guanine nucleotide exchange factor family, is involved in various cancers, including gastric cancer, breast cancer and glioma. However, role NET1 hepatocellular carcinoma (HCC) remains largely uncovered. In this study, we found that expression was upregulated HCC, closely associated with poor prognosis some clinical characteristics HCC patients. Whilst forced cells observed to significantly promote growth metastasis vitro vivo;...
The use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research been conducted on the overall survival (OS) patients with varying tumor responses and treatment duration.This retrospective study analyzed HCC who received sintilimab between January 2019 December 2020 at four centers China. evaluation progression was based Response Evaluation Criteria Solid Tumors version 1.1. investigated correlation response OS, impact drug OS following...
The therapeutic effect of transcatheter arterial chemoembolization (TACE) is limited for patients with hepatocellular carcinoma (HCC). Herein, we designed an open-label, single-arm phase II clinical trial to investigate the efficacy and safety TACE combined atezolizumab plus bevacizumab Barcelona Clinic Liver Cancer (BCLC) stage-B HCC. Patients will initially receive TACE. Atezolizumab be initiated 2-14 days after first session. repeated on demand. primary endpoint objective response rate....
The upregulation of EPH receptor B4 (EPHB4) results in a survival advantage for tumor cells via the inhibition casapse‑8‑mediated apoptotic pathway, which begins from cell membrane. present study investigated expression patterns EPHB4, ephrin B2 (EFNB2) and caspase‑8 patients with esophageal squamous carcinoma (ESCC). association between certain clinicopathological characteristics was also determined. mRNA levels EFNB2 paired primary ESCC samples adjacent tissues collected 96 were quantified...
Introduction Vascular invasion and metastasis are poor prognostic factors in patients with hepatocellular carcinoma (HCC). The efficacy of available therapeutic regimens for unresectable HCC is not satisfactory portal vein tumour thrombosis (PVTT). Therefore, this open-label, single-arm phase II clinical trial aims to investigate the safety radiotherapy combined atezolizumab plus bevacizumab treating PVTT. Methods analysis We plan enrol diagnosed complicated by Intensity-modulated (IMRT)...
Chao Song, Mengmeng Liu, Ganggang Wang, Zijin Xu, Siyang Han, Maozhen Peng, Liang Wenquan Yaolin Qianzhi Ni, Junyi He
Rho guanine nucleotide exchange factor 16 (ARHGEF16) is a newly discovered Rho-family (GEF) involved in the activation of GTPases. However, its roles colon cancer cell proliferation, migration, and invasion remain unknown. This study analyzed expression ARHGEF16 explored biological effects on cells, so as to find new therapeutic targets for treatment cancer.