A5046922491- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Corrosion Behavior and Inhibition
- Air Quality and Health Impacts
- Physiological and biochemical adaptations
- Rice Cultivation and Yield Improvement
- Radiopharmaceutical Chemistry and Applications
- Concrete Corrosion and Durability
- Amphibian and Reptile Biology
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Electrochemical Analysis and Applications
- Gut microbiota and health
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Fish Ecology and Management Studies
- Reproductive System and Pregnancy
- Drug Transport and Resistance Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Brain Metastases and Treatment
- Telomeres, Telomerase, and Senescence
- Vitamin D Research Studies
- High Altitude and Hypoxia
University of New Mexico
2023-2024
Xi'an Jiaotong University
2024
Shanxi Medical University
2024
NYU Langone Health
2024
New Mexico Cancer Center
2023
Shandong University
2012-2023
Huazhong University of Science and Technology
2006-2022
Sichuan University
2022
Mianyang Central Hospital
2020-2021
University of Electronic Science and Technology of China
2021
Abstract The corrosion behavior of copper in aqueous solutions different pH values was investigated using electrochemical and surface analysis methods. It shown that the mechanism changed with associated morphology surf ace films formed. In solution 3, covered porous products cuprous oxide (Cu2O). Corrosion controlled predominately by diffusion solution. 4 to 5, formation cubic Cu2O on provided a barrier dissolution. anodic process mixed ions 6 9, (Cu2O) became more protective. Diffusion...
BackgroundThe comparison between relatively intact nanoscale extracellular vesicle-derived DNA (nEV-DNA) and fragmented circulating cell-free (cfDNA) in mutation detection among patients with non-small-cell lung cancer (NSCLC) has not been carried out yet, thus deserves investigation.Patients methodsBoth nEV-DNA cfDNA was obtained from 377 NSCLC known EGFR status 69 controls. The respective EGFRE19del/T790M/L858R interrogated amplification-refractory-mutation-system-based PCR assays...
The carboxyl terminus of Hsc70-interacting protein (CHIP, also named Stub1), a U-box containing E3 ubiquitin ligase, is involved in degradation certain oncogenic proteins. Recent studies indicated that CHIP suppresses tumor progression human cancers by targeting Src-3, hypoxia inducible factor 1α, NF-κB, ErbB2 and c-Myc. Here, we report was downregulated, predominantly, the late stages colorectal cancer (CRC), promoter hypermethylated CRC specimens. Overexpression HCT-116 cells resulted...
Essential metals play important roles in the carcinogenic process. However, seldom longitudinal investigations have evaluated their lung cancer development. We aimed to investigate associations between multiple essential and incidence explore potential mechanisms. A nested case-control study of 440 incident cases 1:3 frequency matched 1320 healthy controls from Dongfeng-Tongji Cohort was conducted. The baseline plasma concentrations 11 (cobalt, copper, iron, manganese, molybdenum, rubidium,...
Abstract Systemic immune-inflammation index (SII) emerged as a biomarker of chronic inflammation and an independent prognostic factor for many cancers. We aimed to investigate the associations SII level with total cause-specific mortality risks in general populations, potential modification effects lifestyle-related factors on above associations. In this study, we included 30,521 subjects from Dongfeng-Tongji (DFTJ) cohort 25,761 National Health Nutrition Examination Survey (NHANES)...
Observational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk postmenopausal breast cancer. However, whether UA is causally induced by BMI functioned in BMI-breast cancer relationship remains unclear.To elucidate causality direction between UA, bidirectional Mendelian randomization (MR) analyses were performed using summarized data from largest Asian genome-wide association (GWAS) carried out...
The important contribution of dietary triggers to migraine pathogenesis has been recognized. However, the potential causal roles many habits on risk in whole population are still under debate. objective this study was determine association between and (and its subtypes) development, as well possible mediator factors.Based summary statistics from large-scale genome-wide studies, we conducted two-sample Mendelian randomization (MR) bidirectional MR investigate associations 83 subtypes, network...
Abstract Phrynocephalus vlangalii is a species of lizard endemic in China, which lives on Qinghai‐Tibet Plateau ranging from 2000 to 4600 m above sea level. In this study, P. were collected low altitude (2750 m) and high (4564 m). The lizards acclimatized simulated hypoxic chamber (equivalent for 7, 15, 30 days. hematological parameters, heart weight, myocardial capillary density, enzyme activities examined. results showed that acclimatization hypoxia significantly increased hemoglobin...
Thallium (Tl) is a cumulative high toxicant in the environment, but few longitudinal studies have investigated respiratory impairment of Tl exposure.This study aimed to evaluate effect and its interaction with smoking on lung function decline, explore potential mechanisms.The baseline follow-up functions were measured from prospective cohort 1243 workers, who followed 2010 2014. Their urinary levels determined. We also plasma C-reactive protein (CRP) 8-iso-prostaglandin-F2α (8-iso-PGF2α)...
Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed evaluate independent effects and relationships of WBC subtypes with function.The 19,159 participants from NHANES 2011-2012 (n = 3570), coke-oven workers (COW, n 1762) Dongfeng-Tongji (DFTJ, 13,827) cohorts were included in the observational studies. The associations between circulating prebronchodilator evaluated by linear regression models LASSO used...
Phrynocephalus erythrurus (Lacertilia: Agamidae) is considered to be the highest living reptile in world (about 4500-5000 m above sea level), whereas przewalskii inhabits low altitudes 1000-1500 level). Here, we report differences hematological traits between these two different species. Compared with P. przewalskii, results indicated that own higher oxygen carrying capacity by increasing red blood cell count (RBC), hemoglobin concentration ([Hb]) and hematocrit (Hct) elevations could...
This study aims to establish a biological age (BA) predictor and investigate the roles of lifestyles on aging. The 14,848 participants with available information multisystem measurements from Dongfeng-Tongji cohort were used estimate BA. We developed composite BA showing high correlation chronological (CA) (r = 0.82) by using an extreme gradient boosting (XGBoost) algorithm. average frequency hearing threshold, forced expiratory volume in 1 second (FEV1 ), gender, systolic blood pressure,...