A5100746402- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Demographic Trends and Gender Preferences
- Transgenic Plants and Applications
- Carcinogens and Genotoxicity Assessment
- Antimicrobial Peptides and Activities
- Cleft Lip and Palate Research
- Effects and risks of endocrine disrupting chemicals
- Corporate Social Responsibility Reporting
- Psychometric Methodologies and Testing
- Digital Platforms and Economics
- Dermatoglyphics and Human Traits
- Reinforcement Learning in Robotics
- Banking stability, regulation, efficiency
- Water Resources and Management
- Digital Imaging for Blood Diseases
- Advanced Clustering Algorithms Research
- Angiogenesis and VEGF in Cancer
- Advanced Statistical Modeling Techniques
- Heavy Metal Exposure and Toxicity
- Adversarial Robustness in Machine Learning
- Selenium in Biological Systems
Southwest Jiaotong University
2022-2025
Huazhong University of Science and Technology
2019-2022
Cixian People's Hospital
2020-2021
Peking University
2020
Peking University Cancer Hospital
2020
Chongqing Technology and Business University
2018
Shanghai Normal University
2013-2018
Peking Union Medical College Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Capital Medical University
2011-2017
Essential metals play important roles in the carcinogenic process. However, seldom longitudinal investigations have evaluated their lung cancer development. We aimed to investigate associations between multiple essential and incidence explore potential mechanisms. A nested case-control study of 440 incident cases 1:3 frequency matched 1320 healthy controls from Dongfeng-Tongji Cohort was conducted. The baseline plasma concentrations 11 (cobalt, copper, iron, manganese, molybdenum, rubidium,...
Abstract Motivation The rapid development of single-cell RNA sequencing (scRNA-seq) has significantly advanced biomedical research. Clustering analysis, crucial for scRNA-seq data, faces challenges including data sparsity, high dimensionality, and variable gene expressions. Better low-dimensional embeddings these complex should maintain intrinsic information while making similar close dissimilar distant. However, existing methods utilizing neural networks typically focus on minimizing...
In patients with gastric cancer (GC), circulating microRNA-21 (miR-21) is overexpressed and may serve as a diagnostic biomarker. the present study, it was hypothesized that serum miR-21 expression levels were associated prognosis in GC. The of measured using quantitative polymerase chain reaction (qPCR) assays 103 GC patients. Survival Cox proportional-hazards regression analyses performed to determine correlation between clinicopathological factors also analyzed. curves not significantly...
The spectrum and frequency of BRCA1/2 pathogenic variants may be ethnicity‐specific. Whether high‐frequency founder mutations are present in Chinese women remains largely unknown. In the current study, germline genes were determined 9,505 unselected Han breast cancer (BC) patients by next‐generation and/ or Sanger sequencing. Four hundred seventy‐one (5.0%) BC carried this cohort. A total 25 recurrent (at least found four unrelated patients) identified cohort (8 BRCA1 17 BRCA2 variants), 161...
The microRNA (miRNA), miR‑34a is significant in colon cancer progression. In the present study, role of cell proliferation and metastasis was investigated. It found that expression tissues lines lower when compared with normal cells. Further research demonstrated inhibited proliferation, induced G1 phase arrest, suppressed epithelial mesenchymal transition Bioinformatic prediction indicated platelet‑derived growth factor receptor α (PDGFRA) a potential target gene luciferase assay identified...
LINC01320 is a new oncogenic gene. Nevertheless, the effect of on pancreatic cancer (PC) still unclear. This research aimed to seek influence PC and its possible mechanism.RT-qPCR used test in tissues cells. Cell viability, apoptosis, migration, invasiveness are detected explore role PC, target genes predicted by bioinformatics methods. The mechanism action was further explored transfection specific siRNA, miRNA mimetics, or inhibitors. In order verify vivo, we carried out tumor...
Based on a university's practice in upgrading its network management platform, presents visual analytic system which integrates topological space, IP space and geographical into collaborative solution to help administrators address difficulties locating end user troubleshooting. Throughout the development cycle, we worked alongside with users clarify their actual demands habitual operations through scenario application, interviews variety of evaluation. This user-centered approach guides us...
Purpose This study aims to explain why low social conduct in corporate responsibility (SC-CSR), especially employee exploitation, has a stronger negative impact on consumer reactions for service firms than manufacturing firms. Design/methodology/approach Five experiments compared and with SC-CSR. Study 1 used choice-based conjoint design examine the relative importance of various shared attributes when consumers chose services versus goods. 2 revealed that SC-CSR led more pronounced toward...
Fetal adducted thumbs have been described in association with hydrocephalus and other abnormalities, but cases without structural malformations the determination of prognosis recurrence risk is challenging. The aim our study to analyze characteristics, natural history, postnatal outcome such cases. A retrospective was conducted over a period 4 years tertiary referral center. All fetuses diagnosed as comprised group. Prenatal sonographic features neonatal are documented. There were fetal...