A5025694711- Crystallization and Solubility Studies
- Advanced Fiber Laser Technologies
- Laser-Matter Interactions and Applications
- Crystallography and molecular interactions
- Advanced Control Systems Optimization
- X-ray Diffraction in Crystallography
- Laser-Plasma Interactions and Diagnostics
- Photonic Crystal and Fiber Optics
- Drug Solubulity and Delivery Systems
- Algebraic and Geometric Analysis
- Differential Equations and Boundary Problems
- Cyclone Separators and Fluid Dynamics
- Neural Networks and Applications
- Granular flow and fluidized beds
- Advanced Algorithms and Applications
- Laser Design and Applications
- Solid State Laser Technologies
- Fault Detection and Control Systems
- Control Systems and Identification
- Endometrial and Cervical Cancer Treatments
- Adaptive Control of Nonlinear Systems
- Spectroscopy and Chemometric Analyses
- Advanced Fiber Optic Sensors
- Supercapacitor Materials and Fabrication
- Fluid Dynamics and Mixing
De Montfort University
2015-2025
Tongji University
2025
Tianjin Medical University Cancer Institute and Hospital
2023
China University of Petroleum, East China
2013-2023
Peking University
2023
Peking University Cancer Hospital
2023
China Coal Research Institute (China)
2023
China Coal Technology and Engineering Group Corp (China)
2023
Sinopec (China)
2023
Anhui University of Science and Technology
2023
Inspired by the self-assembly of nanoparticle superlattices, we report a general method that exploits long-chain molecular ligands to induce ordered assembly colloidal nanosheets (NSs), resulting in 2D laminate superlattices with high packing density. Co-assembly two types NSs further enables 2D/2D heterostructured superlattices. As proof concept, co-assembly Ti3 C2 Tx and graphene oxide (GO) followed thermal annealing leads MXene-rGO tunable microstructures, which exhibit significantly...
Due to the precisely controllable size, shape, and composition, self-assembled nanocrystal superlattices exhibit unique collective properties find wide applications in catalysis energy conversion. Identifying their intrinsic electrocatalytic activity is challenging, as averaged on ensembles can hardly be dissected from binders or additives. We here report direct measurement of oxygen evolution reaction at single superparticles ∼8 nm NiFe2O4 and/or ∼4 Au nanocrystals using scanning...
BackgroundThe outcome of patients with resectable mucosal melanoma is poor. Toripalimab combined axitinib has shown impressive results in metastatic an objective response rate 48.3% and a median progression free survival 7.5 months phase 1b trial. It was hypothesized that this combination administered the neoadjuvant setting might induce pathologic melanoma, so we conducted trial.Patients methodsThis single-arm II trial enrolled melanoma. Patients received toripalimab 3 mg/kg Q2W plus 5 mg...
ABSTRACT In this article, particle size distributions (PSDs) measured by different techniques, including image analysis (IA), laser diffraction (LD), ultrasonic attenuation spectroscopy (UAS), and focused-beam reflectance measurement (FBRM), are compared for spherical glass beads nonspherical silica flakes. It is shown that shape strongly affects the results obtained techniques. For spheres, PSDs IA, LD, UAS agree well. There no consistent result among techniques particles. The conversion...
Assembling and maintaining large arrays of individually addressable atoms is a key requirement for continued scaling neutral-atom-based quantum computers simulators. In this work, we demonstrate new paradigm assembly atomic arrays, based on synergistic combination optical tweezers cavity-enhanced lattices, the incremental filling target array from repetitively filled reservoir. protocol, provide microscopic rearrangement atoms, while lattices enable creation numbers deep potentials that...
Background/Objectives: Duloxetine, despite being a leading treatment option for major depressive disorder (MDD), exhibits relatively low adequate response rate when used as monotherapy, and the fundamental molecular mechanisms remain largely elusive. tRNA-derived small RNA (tsRNA) is particularly interesting new class of molecules that becoming increasingly noticeable investigation. Methods: We integrated sequencing with bioinformatics approaches to dissect expression profiles tsRNAs...
This study investigated the role of various polymers as precipitation inhibitors in solutions flufenamic acid (FFA) and its cocrystals with theophylline (FFA–TP) nicotinamide (FFA–NIC). Through a combination NMR spectroscopy, molecular dynamics simulations, nucleation studies using Crystal16, we evaluated effects polyethylene glycol (PEG), polyvinylpyrrolidone–vinyl acetate (PVP–VA), soluplus (SOL), both individually combinations, on nucleation, diffusion, self-association FFA molecules...
The influence of the surfactants sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility dissolution behaviour has been studied in this work. CBZ–NIC was determined by measuring eutectic concentrations drug coformer. Evolution intrinsic rate (IDR) monitored UV imaging system during dissolution. Experimental results indicated that SLS had little upon but they totally opposite effects IDR significantly increased while decreased its IDR.
The development of enabling formulations is a key stage when demonstrating the effectiveness pharmaceutical cocrystals to maximize oral bioavailability for poorly water soluble drugs. Inhibition drug crystallization from supersaturated cocrystal solution through fundamental understanding nucleation and crystal growth important. In this study, influence three polymers polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), copolymer N-vinly-2-pyrrodidone (60%) vinyl acetate (40%) (PVP-VA) on...
Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior cocrystals flufenamic acid with theophylline (FFA-TP CO) nicotinamide (FFA-NIC were investigated at multiple length scales. At molecular level, interactions crystal surfaces a polymer analyzed by observing etching pattern changes using atomic force microscopy. macroscopic scale, rates particular faces single determined...
A novel titanium(IV) oxo cluster comprised solely of Ti, O, and H atoms, [Ti6(Oμ)8(OtH2)20]8+ (Ti6) was synthesized in high yield via controlled hydrolysis condensation TiX4 (X = Cl, Br) the presence TBAX (TBA tetrabutylammonium; X from water, while reactions TiI4 TBAI yielded [Ti8O12(OH2)24]8+ (Ti8). The structures compositions clusters were determined by single-crystal X-ray crystallography, powder diffraction, inductively coupled plasma atomic emission spectrometry, energy-dispersive...
Apigenin (4′,5,7-trihydroxyflavone, APG) has many potential therapeutic benefits; however, its poor aqueous solubility limited clinical applications. In this work, a large scale cocrystal screening been conducted, aiming to discover APG cocrystals for enhancement of and dissolution rate. order reduce the number experimental tests, three computational prescreening tools, i.e., molecular complementarity (MC), hydrogen bond propensity (HBP), energy (HBE), were used provide an initial selection...