A5102900660- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Pneumonia and Respiratory Infections
- Enterobacteriaceae and Cronobacter Research
- Salmonella and Campylobacter epidemiology
- Bacterial Genetics and Biotechnology
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Urinary Tract Infections Management
- Biosimilars and Bioanalytical Methods
- Neonatal and Maternal Infections
- Polyomavirus and related diseases
- Protein Tyrosine Phosphatases
- Health and Medical Research Impacts
- Microbial Metabolism and Applications
- Evolution and Genetic Dynamics
- Advanced Chemical Sensor Technologies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Research and Treatments
- Milk Quality and Mastitis in Dairy Cows
Center for Discovery
2021-2025
Hackensack Meridian Health
2021-2024
Rutgers, The State University of New Jersey
2014-2018
Rutgers New Jersey Medical School
2015-2018
Cancer Research And Biostatistics
2016
University Hospital, Newark
2014
University of Toronto
1993
Princess Margaret Cancer Centre
1993
Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the most problematic antimicrobial-resistant bacteria. We sought to elucidate international epidemiology and clinical impact CRAb. In a prospective observational cohort study, 842 hospitalized patients with CRAb culture were enrolled at 46 hospitals in five global regions between 2017 2019. The primary outcome was all-cause mortality 30 days from index culture. strains underwent whole-genome analysis. Of cases, 536 (64%) represented...
Community-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat.In CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission. Healthcare-associated CRE (HA-CRE) were those the lowest likelihood community acquisition, not home cultured >48 after Specific genetic markers in carbapenemase-producing Klebsiella pneumoniae evaluated through random forest modelling.CA-CRE HA-CRE...
Abstract Background Hematopoietic cell transplant (HCT) recipients and patients with acute leukemia are at high risk of Gram-negative bacteremia during neutropenia. Fluoroquinolone (FQ) prophylaxis is used to prevent bacterial infections neutropenia, but the impact colonization FQ-resistant Enterobacterales (FQRE) on its effectiveness unclear. Methods Adult undergoing HCT or receiving induction chemotherapy for were enrolled 10 U.S. centers from 2021 2023. Patients received FQ Perianal swabs...
Carbapenem-resistant and virulence plasmid-harboring Klebsiella pneumoniae (pVir-CRKP) has emerged spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbapenem-resistant K. isolates multicenter US cohort identified 6 pVir-CRKP isolates, including 2 sequence type (ST) 23, ST893, ST11 isolates. Patients infected with experienced high Pitt bacteremia scores 33% 30-day mortality rate. The exhibited significant...
Abstract Background VNRX-5133 is a cyclic boronate β-lactamase inhibitor (BLI) currently in clinical development with cefepime to treat multidrug-resistant (MDR) infections caused by ESBL- and carbapenemase-producing Enterobacteriaceae (ENT) P. aeruginosa (PSA). has direct inhibitory activity against serine-active site β-lactamases (Ser-BL) emerging VIM/NDM metallo-β-lactamases (MBL). We show herein that cefepime/VNRX-5133 highly active MDR-K. pneumoniae isolates producing BL-variants...
A total of 374 clinical isolates Enterococcus spp. were characterized to determine the species distribution and vancomycin resistance. The ability Vitek system (bioMerieux Inc, Hazelwood, St. Louis, Mo.) identify enterococci level recognize resistance by using computer software version 7.1 was evaluated. Conventional methods used for identification agar dilution susceptibility testing, results which as follows (presented number vancomycin-resistant isolates/number members that identified):...
Molecular typing using repetitive sequenced-based PCR (rep-PCR) and hsp60 sequencing were applied to a collection of diverse Enterobacter cloacae complex isolates. To determine the most practical method for reference laboratories, we analyzed 71 E. isolates from sporadic outbreak occurrences originating 4 geographic areas. While rep-PCR was more discriminating, provided broader objective geographical tracking similar multilocus sequence (MLST). In addition, suggest that MLST may have higher...
Bacterial pneumonia is a common complication in hospitalized patients and it associated with high morbidity mortality. Standard culture-based methods may take 2–3 days to identify the etiologies of HAP, leading delays appropriate therapy. A rapid molecular assay that could diagnose etiology bacterial directly from BAL samples within few hours facilitate faster more directed administration antimicrobial were collected suspected pneumonia, including ventilated patients, December 2016 through...
Bacteremia caused by ceftriaxone-resistant Enterobacteriaceae (CRO-R-E) is associated with inadequate empirical therapy and high mortality in neutropenic patients. Increased knowledge of rates CRO-R-E colonization risk bacteremia these patients needed. From November 2015 to Apr 2017, we collected stool or perianal swab samples from acute leukemia upon initiation induction chemotherapy weekly thereafter during neutropenia. Patients less than 7 days neutropenia while an inpatient were...
ABSTRACT Carbapenem resistant Enterobacteriaceae (CRE) have emerged as a critical public health threat. Organisms expressing the Klebsiella pneumoniae carbapenemase (KPC) were first recognized in US late 1990s and continue to be predominant CRE genotype reported clinical isolates. Strains harboring bla KPC alleles been observed multiple species of , including Enterobacter cloacae complex. A major E. clone, xiangfangensis ST171, has an important cause hospital associated infections (HAI)...