A5003533483- Advancements in Battery Materials
- Influenza Virus Research Studies
- Advanced Battery Materials and Technologies
- Supercapacitor Materials and Fabrication
- Respiratory viral infections research
- Advanced Battery Technologies Research
- Diabetes and associated disorders
- Extraction and Separation Processes
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Neonatal and Maternal Infections
- X-ray Diffraction in Crystallography
- Interconnection Networks and Systems
- Animal Virus Infections Studies
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Biochemical and Structural Characterization
- Quantum Dots Synthesis And Properties
- Streptococcal Infections and Treatments
- Magnetic Properties and Synthesis of Ferrites
University of Pennsylvania
2022-2025
California University of Pennsylvania
2024
Guilin University of Technology
2008-2015
Bureau of Geology and Mineral Exploration and Development of Guizhou Province
2013
UConn Health
2007
Guilin University of Electronic Technology
2004
Seasonal influenza vaccines offer little protection against pandemic virus strains. It is difficult to create effective prepandemic because it uncertain which subtype will cause the next pandemic. In this work, we developed a nucleoside-modified messenger RNA (mRNA)-lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known A subtypes and B lineages. This multivalent elicited high levels of cross-reactive subtype-specific antibodies in mice ferrets that reacted encoded...
Abstract mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian viruses from H5 clade 2.3.4.4b are circulating at unprecedently high levels in wild domestic birds have potential to adapt humans. Here, we generate encoding hemagglutinin (HA) glycoprotein a isolate. The mRNA-LNP elicits strong T cell antibody responses female mice,...
A new anatase/rutile TiO2 nanocomposite microspheres (ART) electrode with hierarchically porous structures was successfully synthesized by a one-step route under mild hydrothermal conditions. The morphology, crystal structure and phase composition, specific surface area pore size distribution of the obtained were systematically investigated X-ray diffraction (XRD), Raman spectroscopy, field-emission scanning electron microscopy (FESEM), high resolution transmission (HRTEM) nitrogen...
Abstract Avian H5N1 influenza viruses are circulating widely in cattle and other mammals pose a risk for human pandemic. Previous studies suggest that older humans more resistant to infections due childhood imprinting with group 1 (H1N1 H2N2); however, the immunological basis this is incompletely understood. Here we show antibody titers historical recent strains highest individuals correlate strongly year of birth than age, consistent immune imprinting. After vaccination an...
Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 is circulating widely in lactating cows the United States. Due to critical need for intervention strategies this outbreak, we evaluated antibody and cellular immune responses of a H5 mRNA-LNP vaccine calves. We found that induced robust CD8+ T cellular-mediated response conferred protection against infection.
Anatase TiO2 mesocrystals with a Wulff construction of nearly 100% exposed {101} facets were successfully synthesized by facile, green solvothermal method. Their morphology, and crystal structure are characterized powder X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM) high-resolution transmission (HRTEM). Accordingly, possible growth mechanism anatase is elucidated in this work. The as-prepared single mesocrystal's mean center diameter about 500 nm, the length 1...
A continuous hollow TiO2 structure with three-dimensional (3D) interconnected anatase single crystals self-assembled into compact large pore mesoporous shells had been fabricated in this paper. The as-obtained hierarchically micro/nano-structured materials, denoted as CTAB–TiO2, are simply prepared via a hydrothermal method the assistance of cetyltrimethylammonium bromide (CTAB) micelles. results show that both CTAB and thermal treatment played key role forming micro/nano-structure...
Studies have reported that repeated annual vaccination may influence influenza effectiveness in the current season. We established a 5-year randomized placebo-controlled trial of (Flublok; Sanofi Pasteur) adults 18-45 years age. In first 2 years, participants were to receive vaccine or saline placebo as follows: placebo-placebo (P-P), placebo-vaccine (P-V), vaccine-vaccine (V-V). Serum samples collected each year just before and after 30 182 days. A subset serum at 5 time points from 95...
Fe<sub>2</sub>(MoO<sub>4</sub>)<sub>3</sub> nanoparticle-anchored MoO<sub>3</sub> nanowires <italic>via</italic> strong coupling the reverse diffusion of heteroatoms and largely enhanced lithium-storage properties due to synergistic effect nanoparticles nanowires.
Highly pathogenic avian influenza viruses from H5 clade 2.3.4.4b are circulating at unprecedently high levels in wild and domestic birds have the potential to adapt humans. We generated an mRNA lipid nanoparticle (LNP) vaccine encoding hemagglutinin (HA) glycoprotein a isolate. show that is immunogenic mice ferrets prevents morbidity mortality of following H5N1 challenge.
ABSTRACT Background Studies have reported that repeated annual vaccination may influence the effectiveness of influenza in current season. The mechanisms underlying these differences are unclear but might include “focusing” adaptive immune response to older strains. Methods We established a 5-year randomized placebo-controlled trial (Flublok, Sanofi Pasteur) adults 18-45 years age. Participants were equally between five groups, with planned receipt (V) or saline placebo (P) as follows:...