A5012957755- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Polish Legal and Social Issues
- Ubiquitin and proteasome pathways
- Receptor Mechanisms and Signaling
- Microtubule and mitosis dynamics
- Customer Service Quality and Loyalty
- Glycosylation and Glycoproteins Research
- Biochemical Analysis and Sensing Techniques
- finance, banking, and market dynamics
Wellcome/MRC Institute of Metabolic Science
2021
Addenbrooke's Hospital
2021
University of Cambridge
2021
National Institute for Health Research
2021
NIHR Cambridge Biomedical Research Centre
2021
Medical Research Council
2021
University of Warwick
2018
Bialystok University of Technology
2018
GNAS encodes the Gαs (stimulatory G-protein alpha subunit) protein, which mediates G protein-coupled receptor (GPCR) signaling. mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright's hereditary osteodystrophy. Because of imprinting, on maternal allele also obesity hormone resistance (pseudohypoparathyroidism).We performed exome sequencing targeted resequencing 2548 children who presented with severe obesity, we unexpectedly identified...
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate function. Most obesity-associated impair trafficking the plasma membrane (PM), whereas obesity-protecting either accelerate recycling PM decrease internalization, resulting enhanced signaling. do not affect canonical Gαs protein-mediated signaling, previously considered be non-pathogenic,...
EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly by acting as hub tip-tracking network. Mammalian cells express cell type-specific combinations three with different cellular roles. Here, we reconstitute EB1, EB2 EB3 tip tracking in vitro We find that all EBs show rapid exchange at their signal correlates to assembly rate. However, signals differ maxima position from tip. Using built nucleotide analogues site-directed mutagenesis, prefers...
J Cell Rep. 2021 Mar 23;34(12):108862. 10.1016/j.celrep.2021.108862. https://pubmed.ncbi.nlm.nih.gov/33761344/