A5083724932- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Cancer survivorship and care
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Cervical Cancer and HPV Research
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Polyomavirus and related diseases
- Silicon Carbide Semiconductor Technologies
- Family Support in Illness
- T-cell and Retrovirus Studies
- Advanced Radiotherapy Techniques
- Advancements in Semiconductor Devices and Circuit Design
- Bone and Joint Diseases
University of Wisconsin Carbone Cancer Center
2020-2024
University of Wisconsin–Madison
2020-2024
Mayo Clinic in Arizona
2016-2020
National Heart Lung and Blood Institute
2011-2020
National Institutes of Health
2012-2020
Highland Community College - Illinois
2020
Cleveland Clinic
2014-2019
Mayo Clinic
2016-2018
WinnMed
2017
National Center for Advancing Translational Sciences
2016
PURPOSE CNS progression or relapse is an uncommon but devastating complication of aggressive B-cell lymphoma. There no consensus regarding the optimal approach to prophylaxis. This study was designed determine whether high-dose methotrexate (HD-MTX) effective at preventing in patients high risk this complication. PATIENTS AND METHODS Patients age 18-80 years with lymphoma and progression, treated curative-intent anti–CD20-based chemoimmunotherapy, were included international, retrospective,...
Checkpoint inhibitor (CPI) therapy with anti-PD-1 antibodies has been associated mixed outcomes in small cohorts of patients relapsed aggressive B-cell lymphomas after CAR-T failure. To define CPI efficacy more definitively this population, we retrospectively evaluated clinical a large cohort 96 receiving failure across 15 US academic centers. Most (53%) had diffuse lymphoma, were treated axicabtagene ciloleucel (53%), early (≤180 days) (83%), and received pembrolizumab (49%) or nivolumab...
While MYC translocations in B-cell lymphoma (BCL) have been extensively studied, the significance of amplification (MYC amp) is poorly understood. This study characterizes BCL showing amp, defined as uncountable FISH signals. Retrospective analysis all for aberrations performed at our institution (1/2010-2/2018) identified 44/9715 (0.45%) cases with amp. amp probe signals appeared a cloud-like distribution (70%) or single homogenous-staining-region (30%). In total 59% also had separation by...
7006 Background: Rituximab maintenance (RM) after first-line (1L) bendamustine and rituximab (BR) in MCL did not improve progression-free survival the MAINTAIN trial (Rummel et al, ASCO 2016) but was associated with improved outcomes a North American observational study (Martin JCO 2023). We sought to examine potential benefit of RM BR using large cohort from 26 US academic centers. Methods: Patients who received 1L (without stem cell transplant) outside clinical trials were included. At...
Abstract The impact of physical activity (PA) on lymphoma survival is not known. association PA and change in with overall (OS), lymphoma‐specific (LSS) event‐free (EFS) was evaluated a prospective cohort newly diagnosed patients (2002‐2012). We calculated Leisure Score Indexes (mLSI) from the self‐reported usual adult (baseline) at 3‐years post‐diagnosis (FU3), grouping by active vs insufficiently American Cancer Society guidelines. Associations were assessed using hazard ratios (HRs) 95%...
Both early- and late-onset noninfectious pulmonary injury are important contributors to the nonrelapse mortality seen after allogeneic stem cell transplantation (allo-SCT), particularly in subjects conditioned with high-dose total body irradiation (TBI). To characterize kinetics of recovery from long-term survivors, we collected data on 138 who survived > 3 years (median survival, 10.2 years) predominantly TBI-based allo-SCT their HLA-matched siblings. Baseline function tests served as...
Given the occurrence of cancer during a complex developmental time, adolescent and young adult (AYA) patients have unique psychosocial needs that necessitate supportive care, which is optimally provided using National Comprehensive Cancer Network (NCCN) AYA guidelines. We sought to explore compliance with NCCN guidelines compare oncology providers' perceptions care needs.Retrospective chart reviews (15-39 years at time diagnosis) sarcoma seen least once in 2019 University Wisconsin...
The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 assess the association BMI before diagnosis, at change over time with lymphoma-specific (LSS). A total 4009 (670 diffuse large B-cell (DLBCL), 689 follicular (FL), 1018 chronic lymphocytic leukemia/small (CLL/SLL), 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was...