Tomo Hayase
A5008177685- Neutropenia and Cancer Infections
- Advanced Biosensing Techniques and Applications
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Hematopoietic Stem Cell Transplantation
- Single-cell and spatial transcriptomics
- Clostridium difficile and Clostridium perfringens research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Microscopic Colitis
- Cystic Fibrosis Research Advances
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
Anderson University - South Carolina
2025
The University of Texas MD Anderson Cancer Center
2021-2024
Immune checkpoint inhibitors (ICIs) target advanced malignancies with high efficacy but also predispose patients to immune-related adverse events like immune-mediated colitis (IMC). Given the association between gut bacteria response ICI therapy and subsequent IMC, fecal microbiota transplantation (FMT) represents a feasible way manipulate microbial composition in patients, potential benefit for IMC. Here, we present large case series of 12 refractory IMC who underwent FMT from healthy...
Not all patients with cancer and severe neutropenia develop fever, the fecal microbiome may play a role. In single-center study of undergoing hematopoietic cell transplant ( n = 119), was characterized at onset neutropenia. A total 63 (53%) developed subsequent their displayed increased relative abundances Akkermansia muciniphila , species mucin-degrading bacteria P 0.006, corrected for multiple comparisons). Two therapies that induce neutropenia, irradiation melphalan, similarly expanded A....
<title>Abstract</title> <bold>Introduction</bold>: Immune checkpoint inhibitors have revolutionized cancer therapy; however, adverse events from an unchecked immune system such as inhibitor mediated diarrhea and colitis (IMDC) can develop. Fecal microbiota transplantation (FMT) remains option for patients with refractory colitis, but has not been tested in upfront setting. <bold>Methods</bold>: From open-label, phase I/II clinical trial (NCT0403861) starting June 2021, we report analysis of...
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the microbiota known to impact on its severity. However, an association between treatment response aGI-GVHD has not been well-studied. In cohort patients with (n=37), we found that non-response standard therapy corticosteroids was associated prior carbapenem antibiotics loss
Abstract Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, which includes antigen-presenting cells (APC) with Fas-inducible NF-κB and T nuclear factor activated (NFAT) reporter. To functionally screen target antigens from cDNA library, productively interacting cell–APC aggregates were detected by dual-reporter...
<div>Abstract<p>Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, which includes antigen-presenting cells (APC) with Fas-inducible NF-κB and T nuclear factor activated (NFAT) reporter. To functionally screen target antigens from cDNA library, productively interacting cell–APC aggregates were...
<p>Tsyn-seq system spike-in assay.</p>
<p>Activation of Fas-iNFκB reporter in FIR-APCs.</p>
<p>Supplementary Data</p>
<p>Supplementary Data</p>
<p>Aggregates of interacting target cells and T cells.</p>
<p>Aggregates of interacting target cells and T cells.</p>
<p>Generation of reporter cells overexpressing CaSki cDNA library.</p>
<p>Tsyn-seq system spike-in assay.</p>
<div>Abstract<p>Tools for genome-wide rapid identification of peptide–major histocompatibility complex targets T-cell receptors (TCR) are not yet universally available. We present a new antigen screening method, the T-synapse (Tsyn) reporter system, which includes antigen-presenting cells (APC) with Fas-inducible NF-κB and T nuclear factor activated (NFAT) reporter. To functionally screen target antigens from cDNA library, productively interacting cell–APC aggregates were...
<p>Generation of reporter cells overexpressing CaSki cDNA library.</p>
<p>Activation of Fas-iNFκB reporter in FIR-APCs.</p>
Abstract Not all cancer patients with severe neutropenia develop fever, and the fecal microbiome may play a role. In neutropenic hematopoietic cell transplant (n=119), 63 (53%) developed subsequent fever had increased Akkermansia muciniphila , mucus-degrading bacteria (p=0.006, corrected for multiple comparisons). mouse models, two therapies, irradiation melphalan, similarly expanded A. . Dietary restriction of unirradiated mice also thinned colonic mucus layer. Azithromycin treatment...