A5000335501- Glioma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Chromatin Remodeling and Cancer
- Microtubule and mitosis dynamics
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmacological Effects and Toxicity Studies
- Magnetism in coordination complexes
- Plasmonic and Surface Plasmon Research
- Renal cell carcinoma treatment
- Single-cell and spatial transcriptomics
University Medical Center Hamburg-Eppendorf
2023-2024
Universität Hamburg
2023-2024
University Hospital Münster
2020-2021
Uniwersytecki Szpital Dziecięcy
2018
Children's Clinical University Hospital
2018
Abstract Background Molecular brain tumor diagnosis is usually dependent on tissue biopsies or resections. This can pose several risks associated with anesthesia neurosurgery, especially for lesions in the stem other difficult-to-reach anatomical sites. Apart from initial diagnosis, progression, recurrence, acquisition of novel genetic alterations only be proven by re-biopsies. Methods We employed Nanopore sequencing cell-free DNA (cfDNA) cerebrospinal fluid (CSF) and analyzed copy number...
As<sub>2</sub>O<sub>3</sub>was introduced as an anion into MOF nanoparticles<italic>via</italic>a postsynthetic ligand exchange; material cytotoxicity was investigated<italic>in vitro</italic>.
Abstract BACKGROUND Medulloblastoma (MB) is one of the most frequent high-grade brain tumor types childhood and adolescence. Based on biology, histology, its clinical course, MB a heterogeneous disease with four different molecular (WNT, SHH, Group 3, 4), which are reliably distinguishable by their global DNA methylation pattern. METHODS We analyzed (n=47), copy number variants, transcriptomic data (n=7) histology (n=28) previously unrecognized type MB. RESULTS As result integrating...
Abstract BACKGROUND European Reference Networks (ERN) are collaborative networks connecting healthcare professionals across Europe. A virtual tumor board for pediatric patients with central nervous system (CNS) tumors was established within the ERN oncology (ERN PaedCan) in September 2022. We report feasibility, implementation of recommendations and satisfaction participants. METHODS web-based questionnaire distributed to physicians presenting cases between November 2022 2023. Questions...
Abstract BACKGROUND Outcome of children with medulloblastoma (MB) and Fanconi Anemia (FA), an inherited DNA repair deficiency, has not systematically been described. Treatment is complicated by high vulnerability to treatment-associated side effects, yet structured data are lacking. This study provides a comprehensive overview about clinical molecular characteristics pediatric FA MB patients. METHODS Clinical including detailed information on treatment toxicities six previously unreported...
The outcome of children with medulloblastoma (MB) and Fanconi Anemia (FA), an inherited DNA repair deficiency, has not been described systematically. Treatment is complicated by high vulnerability to treatment-associated side effects, yet structured data are lacking. This study aims give a comprehensive overview clinical molecular characteristics pediatric FA MB patients. Clinical including detailed information on the treatment toxicities 6 previously unreported patients were supplemented 16...
Abstract For exact molecular diagnosis of CNS tumors, tumor tissue obtained through surgery is usually needed. However, knowledge on the type beforehand might influence surgical strategies and reduce surgery-associated risks. Molecular analyses liquid biopsies have therefore gained increasing interest in order to secure before or replace rare instances. Moreover, minimally invasive nature enables a tight longitudinal monitoring with potentially higher sensitivity than imaging approaches. In...
Abstract Atypical Teratoid Rhabdoid Tumors (ATRT) are aggressive brain malignancies of the infant. Despite intensive multimodal therapy, overall prognosis remains poor, making investigations on targeted therapies crucial. Arsenic trioxide (ATO) is known to inhibit cell growth ATRT in vitro and vivo but its efficacy solid tumors limited by adverse effects. We aimed characterize whether a nanoparticle-based drug delivery could overcome these limitations. Therefore metal-organic frameworks...