A5018583535- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Religion, Spirituality, and Psychology
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- Pediatric Pain Management Techniques
- Pancreatic and Hepatic Oncology Research
- Hedgehog Signaling Pathway Studies
- RNA Interference and Gene Delivery
- Iron Metabolism and Disorders
- Patient-Provider Communication in Healthcare
- Pharmacological Effects and Toxicity Studies
- Protein Degradation and Inhibitors
- Pain Management and Opioid Use
Dell Children's Medical Center of Central Texas
2023-2024
Nemours Children's Health System
2023-2024
Dupont Hospital
2021-2024
DuPont (United States)
2024
Children's Hospital of Philadelphia
2010-2013
University of Pennsylvania
2012
Summary Pain is not a symptom generally associated with thalassaemia. However, providers have noted increasing patient reports of pain, creating an impetus for this prospective, observational assessment pain in thalassaemia patients. The primary study goals were to assess prevalence, severity, location, and potential risk factors. This was multicentre, prospective patients receiving care at 12 Thalassaemia Clinical Research Network sites. assessed using the Brief Inventory. Two hundred...
Pain reports have become increasingly common and problematic in thalassemia. As patients are living longer,there is a growing need to study pain explore its impact on patient lives. The Brief Inventory(BPI) was used quarterly assess interference with thalassemia North America.The Medical Outcomes Study 36-Item Short Form Health Survey the Hospital Anxiety Depression Scale were quality of life, anxiety depression. Of 252 participants, 56% reported at least once over course this study, 32%...
Medulloblastomas (MB) are the most commonly occurring malignant brain tumour in childhood. The mainstay of therapy incorporates gross total resection followed by craniospinal irradiation (CSI) and chemotherapy. To guide post-surgical treatment, patients assigned to average-risk or high-risk groups depending on their age at presentation, presence metastases diagnosis extent postoperative residual disease [1]. recent WHO classification scheme for medulloblastoma divides a into four molecularly...
Aim To assess the feasibility of collecting electronic pain data from thalassaemia patients, based on its acceptability and convenience to participants study team. Methods Participants in Thalassemia Clinical Research Network Assessment Pain Survey Study completed Brief Inventory (BPI) quarterly by paper or phone interview. a substudy BPI Short Form daily over three non-consecutive transfusion cycles through an automated telephone system. Results The consent rate for main was 93%, with 93%...
Abstract BACKGROUND Medulloblastoma (MB) is one of the most frequent high-grade brain tumor types childhood and adolescence. Based on biology, histology, its clinical course, MB a heterogeneous disease with four different molecular (WNT, SHH, Group 3, 4), which are reliably distinguishable by their global DNA methylation pattern. METHODS We analyzed (n=47), copy number variants, transcriptomic data (n=7) histology (n=28) previously unrecognized type MB. RESULTS As result integrating...
Abstract Objective To describe safety and efficacy of dual targeted therapy with dabrafenib (BRAFi) trametinib (MEKi) in an infant inoperable low grade glioma BRAF V600E mutation. Introduction Safety BRAFi MEKi for pediatric (pLGG) is currently being evaluated, however, infants are usually not included these clinical trials. Case We report a case 2-month-old male who presented involuntary movements gaze deviation concerning seizures. MRI brain revealed tumor involving the medulla, T2/FLAIR...