Thomas S. Risch
A5103216678- Bat Biology and Ecology Studies
- Wildlife Ecology and Conservation
- Animal Ecology and Behavior Studies
- Species Distribution and Climate Change
- Fire effects on ecosystems
- Animal Behavior and Reproduction
- Avian ecology and behavior
- Acute Myeloid Leukemia Research
- Marine animal studies overview
- Viral Infections and Vectors
- Ecology and Vegetation Dynamics Studies
- Physiological and biochemical adaptations
- Plant and animal studies
- Advanced Chemical Sensor Technologies
- Acute Lymphoblastic Leukemia research
- Genomics and Chromatin Dynamics
- Rangeland and Wildlife Management
- Cancer Genomics and Diagnostics
- Engineering and Materials Science Studies
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Landslides and related hazards
- Multidisciplinary Science and Engineering Research
- Protein Degradation and Inhibitors
- Cryospheric studies and observations
Arkansas State University
2011-2023
Arkansas Biosciences Institute
2020-2023
Max Planck Institute for Molecular Genetics
2014-2022
Chemnitz University of Technology
2022
Alacris (Germany)
2020
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Kerckhoff Klinik
2016-2017
Center for Cancer Research
2013-2014
Massachusetts General Hospital
2013-2014
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight need molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify full spectrum of driver genes molecular processes that operate in medulloblastoma subgroups. Here we analyse somatic landscape across 491 sequenced samples heterogeneity among 1,256 epigenetically analysed cases, subgroup-specific...
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics medicine. We carried out high-resolution genetic, epigenetic, transcriptomic profiling three immune cell types (CD14+ monocytes, CD16+ neutrophils, naive CD4+ T cells) from up 197 individuals. assess, quantitatively, relative cis-genetic transcription evaluate their impact as potential sources confounding epigenome-wide association studies. Further, we...
Abstract Colorectal carcinoma represents a heterogeneous entity, with only fraction of the tumours responding to available therapies, requiring better molecular understanding disease in precision oncology. To address this challenge, OncoTrack consortium recruited 106 CRC patients (stages I–IV) and developed pre-clinical platform generating compendium drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived vivo vitro models. This large biobank tumours, 35...
This article introduces a manually curated data collection for gene expression meta-analysis of patients with ovarian cancer and software reproducible preparation similar databases. resource provides uniformly prepared microarray 2970 from 23 studies documented clinical metadata. It allows users to efficiently identify patient subgroups interest analysis perform immediately without the challenges posed by harmonizing heterogeneous technologies, study designs, processing methods formats. We...
Gene expression analysis by RNA sequencing is now widely used in a number of applications surveying the whole transcriptomes cells and tissues. The recent introduction ribosomal depletion protocols, such as RiboZero, has extended view polyadenylated transcriptome to poly(A)- fraction RNA. However, substantial amounts intronic transcriptional activity been reported RiboZero raising issues regarding their potential nuclear origin impact on actual sequence depth exonic regions.Using HEK293...
Ovarian cancer is the fifth leading cause of death for women in U.S. and seventh most fatal worldwide. Although ovarian notable its initial sensitivity to platinum-based therapies, vast majority patients eventually develop recurrent succumb increasingly platinum-resistant disease. Modern, targeted drugs intervene cell signaling, identifying key disease mechanisms pathways would greatly advance our treatment abilities. In order shed light on molecular diversity cancer, we performed...
// Sekyung Oh 1, 2, * , Ryan A. Flynn 3, Stephen N. Floor 4 James Purzner 5, 6 Lance Martin Brian T. Do Simone Schubert 1 Dedeepya Vaka Sorana Morrissy 7, 8 Yisu Li 9 Marcel Kool 10 Volker Hovestadt 11 David T.W. Jones Paul Northcott Thomas Risch 12 Hans-Jörg Warnatz Marie-Laure Yaspo Christopher M. Adams 13 D. Leib Marcus Breese 14 Marco Marra Malkin 15 Peter Lichter Jennifer Doudna 4, 16, 17, 18 Stefan Pfister Michael Taylor 8, 9, 19 Howard Y. Chang 20, # Yoon-Jae Cho 21, 22,...
1. We examined positive associations and trade‐offs of maternal reproductive traits in a population Columbian ground squirrels, Spermophilus columbianus . 2. Structural size, body condition, mother's personal allocation to mass during reproduction, timing littering were estimated for live‐trapped females that observed an 8‐year period, compared litter mass, average pup using path analyses. 3. Mothers exhibited age‐structured influenced patterns. Yearling mothers significantly smaller, bred...
Asian elephants Elephas maximus are an endangered species and human—elephant conflict (HEC) is the major threat to their survival. HEC causes crop property loss occasionally results in death of both humans Nepal. Elephants responsible for more than 40% human—wildlife conflict, 70% wildlife‐caused human casualties, a 25% production Identification factors associated with elephant invasion can help mitigate by allowing residents representatives address those factors. This study used...
White nose syndrome (WNS) is a cutaneous fungal disease of bats. WNS responsible for unprecedented mortalities in North American cave bat populations. There have been few descriptions enzyme activities that may function host/pathogen interactions, while no study has isolated and described secreted proteases. To address the hypothesis Pseudogymnoascus destructans secretes extracellular proteases wing necrosis during infection, object this was to culture P. on various media, then isolate...
Human-elephant Conflict (HEC) is a significant problem in Nepal, with approximately two-thirds of households being impacted by elephants (Elephas maximus), particularly during the winter. In addition to elephant casualties, more than 10% surveyed have had human casualties (injury or death) past 5 years. This study evaluates economic viability conservation Nepal within context current and proposed HEC mitigation scenarios. Face-to-face interviews were carried out using structured...
Processes associated with recovery of survivors are understudied components wildlife infectious diseases. White-nose syndrome (WNS) in bats provides an opportunity to study disease survivors, understand implications for individual energetics, and assess the role pathogen transmission. We documented temporal patterns from WNS little brown (Myotis lucifugus) following hibernation test hypotheses that: (1) wing structure matches a rapid time scale (i.e. approximately 30 days) suggested by data...
Asian elephants are isolated in fragmented habitat patches and around Bardia National Park (BNP), Nepal. To describe use patterns ecogeographical variables (EGVs) that determine an elephant's niche BNP, we used a General Niche-Environment System Factor Analysis (GNESFA) modeling framework. Novel to our study was the comparison of requirements between core (residential) corridor (travel corridor) areas elucidate site-specific preferences BNP. A total 13 EGVs (four topographic variables, six...
Summary Three hypotheses have been proposed to explain age‐structured patterns of reproductive investment and somatic investment: residual value, senescence evolutionary restraint. We evaluated these for female Columbian ground squirrels ( Spermophilus columbianus ) by examining age‐related investment. Females were designated as successful (those that weaned litters) unsuccessful did not wean litters). Somatic varied among both females different ages, with yearlings having the highest...
We studied litter size variation in a population of Richardson's ground squirrels (Spermophilus richardsonii) Alberta, Canada, from 1987 to 2004. Litter at first emergence juveniles the natal burrow ranged 1 14; most common sizes, collectively accounting for 41.0% 999 litters, were 6 and 7. The number offspring surviving adulthood (attained on hibernation as yearlings) increased with increasing size, result that was not predicted by Lack's "optimal size" hypothesis, Mountford's "cliff-edge"...
Habitat degradation has caused a significant threat to wildlife, particularly megafauna including the Asian elephant that large home range. Recolonization of elephants in 1994 and around Bardia National Park (BNP) provided unique study setting address habitat change over two decades (1990–2013). Elephant presence data 2013 was modeled using Ecological Niche Factor Analysis (ENFA), which identified influential ecogeographical variables for habitat. These were further used regression model...
We studied the evolution of litter size in natural and experimentally manipulated populations Columbian ground squirrels (Spermophilus columbianus) eastern Washington state southwest Alberta. Litter at weaning a large population (mean = 3.51 pups/litter, 248 litters) was significantly lower than (6 pups) that produced most offspring surviving to yearling age class. This evidence contradicted Lack's "optimal size" hypothesis, which predicts productive should approximate mean. had no...