This study aimed to evaluate the accuracy and completeness of GPT-4, a large language model, in answering clinical pharmacological questions related pain therapy, with focus on its potential as tool for delivering patient-facing medical information. The objective was assess reliability information context management. A cross-sectional survey-based conducted healthcare professionals, including physicians pharmacists. Participants submitted up 8 pharmacology management, focusing drug...

Significance, origin and nature of posttraumatic brain edema are still being debated. Recently, a "controlled cortical impact injury" (CCII) was introduced to model traumatic injury. Purpose this study investigate the development following CCII. Traumatic injury applied intact dura left hemisphere in Sprague-Dawley rats (n = 52, 250–350 g b.w.). Ketamine/xylazine-anesthesia or inhalation-anesthesia were used. A pneumatic impactor with diameter 5 mm contused temporo-parietal cortex velocity 7...

Brain tissue analysis is highly desired in neurosurgery, such as tumor resection. To guarantee best life quality afterward, exact navigation within the brain during surgery essential. So far, no method has been established that perfectly fulfills this need. Optical coherence tomography (OCT) a promising three-dimensional imaging tool to support neurosurgical resections. We perform preliminary study toward vivo removal assistance by investigating meningioma, healthy white, and gray matter....

Anterior skull base meningiomas represent a wide cohort of tumors with different locations, extensions, configurations, and anatomical relationships. Diagnosis these review their therapies are inseparably connected cranial imaging. We analyzed the influence three-dimensional-virtual reality (3D-VR) reconstructions versus conventional computed tomography (CT) magnetic resonance imaging (MRI) images (two-dimensional (2D) screen 3D) on identification structures surgical planning in patients...

Objective: Tumors in the deep infratentorial region can be accessed via supracerebellar-infratentorial (SCIT) or suboccipital-transcerebellar (SOTC) approaches sitting prone position. Diagnosis of tumors this and review their therapies are inseparably connected with cranial tomographic imaging. We retrospectively evaluate a cohort patients who underwent tumor resection correlate complication rates to literature, potential influence virtual reality (VR) visualization technique on surgery...

Objective of this study was the characterization traumatic brain injury induced by a “Controlled Cortical Impact” with magnetic resonance imaging techniques. The impact applied to intact dura left hemisphere in Sprague-Dawley rats. pneumatic impactor accelerated velocity 7 m/s contusing temporo-parietal depth 2 mm. Posttraumatic hemispheric swelling and water content were determined gravimetrically, Evans Blue extravasation photometrically, volume ischemia TTC-staining planimetry. Magnetic...

Anterior-communicating artery (ACoA) aneurysms have diverse configurations and anatomical variations. The evaluation operative treatment of these necessitates a perfect surgical strategy based on review three-dimensional (3D) angioarchitecture using several radiologic imaging methods. We analyzed the influence 3D virtual reality (VR) reconstructions versus conventional computed tomography angiography (CTA) scans identification vascular anatomy planning in patients with unruptured ACoA...

Abstract Background and Study Aims Spinal fusion for symptomatic lumbar spondylolisthesis can be accomplished using an open or minimally invasive surgical (MIS) technique. Evaluation of segmental instabilities review their therapies are inseparably connected with tomographic imaging. We analyzed a cohort patients who underwent MIS monosegmental dorsal compared outcomes along complication rates. furthermore evaluated the influence virtual reality (VR) visualization on planning in fusion....

Purpose: Large language models (LLM) have recently attracted attention because of their enormous performance. Based on artificial intelligence, LLM enable dialogic communication using quasi-natural that approximates the quality human communication. Thus, could play an important role for patients to become informed. To evaluate validity when providing medical information, we used one first high-performance (ChatGPT) clinical example acute lumbar disc herniation (LDH).Methods: Twenty-four...

Objectives: Following traumatic brain injury metabolic stability is impaired. Duration and reversibility of these changes might be important to guide specific interventions. Methods: To characterize temporal regional in cerebral metabolism, 68 male Sprague–Dawley rats were subjected a focal cortical contusion. Lesion progression mitochondrial impairment determined by magnetic resonance imaging (MRI) triphenyl tetrazolium chloride (TTC) staining, respectively. Metabolic alterations at hours 6...

Das „Mobile Retter“ Modell-Projekt des Kreises Gütersloh intendiert mit der Smartphone-basierten, standortbezogenen Alarmierung von medizinisch qualifizierten Ersthelfern die inakzeptabel hohe Mortalität nach präklinischem Herz-Kreislauf-Stillstand zu senken. vorgestellte Projekt nutzt das große, bereits in Bevölkerung vorhandene Potenzial Ärzten, Rettungsdienstmitarbeitern, Feuerwehrkräften, Sanitätern sowie Gesundheits- und Krankenpflegepersonal (Mobile Retter) zur Einleitung...

(1) Background: In this study, the intraoperative fluorescence behavior of brain metastases after administration 5-aminolevulinic acid (5-ALA) was analyzed. The aim to investigate whether resection using 5-ALA also leads a more complete resections and thus prolongation survival; (2) Methods: following variables have been considered: age, sex, number metastases, localization, involvement eloquent area, correlation between primary tumor/subtype, resection, survival time. influence on degree...

(1) Background: Obesity poses known risks in surgery, including a prolonged operation time and postoperative complications. Given the rising obesity rates frequent lumbar disc surgeries, understanding these is crucial. This study aims to assess impact of on duration complications prolapse surgery. (2) Methods: We retrospectively analyzed 598 patients with monosegmental herniation, correlating their body mass index (BMI) as surrogate parameter for time. Excluding complex cases...

Lubeluzole, a novel nitric oxide synthase (NOS) pathway modulator, was shown to be neuroprotective in cerebral ischemia as studied animal models and clinical trials. The present study investigated the effect of lubeluzole on contusion volume brain edema following traumatic injury. Sprague-Dawley rats (n = 36) were subjected cortical impact Lubeluzole (0.8 mg/kg i.v.; n 18) or corresponding vehicle injected 15 75 minutes trauma. Animals sacrificed 24 hours Contusion measured planimetrically...

Mechanical characteristics of tumor and healthy tissue in the brain differ but slightly. The task designing a system that is able to differentiate dignity with high sensitivity great importance neurosurgery. Even when localization by use preoperative imaging techniques provides surgeon valuable information decide where what resect, shift due change pressure during skull opening demands define limits using tactile visual differentiation. This paper contains general description sensor based on...

Zusammenfassung Ziel der Studie Mit dem Mobile-Retter-System (MR-System) wurde 2013 bundesweit erstmalig die Smartphone-basierte Alarmierung qualifizierter Ersthelfer zur Optimierung des Outcomes nach präklinischem Herz-Kreislauf-Stillstand eingeführt. Hier sollen Unterschiede in MR-Alarmierungen und Rekrutierungen im regionalen Vergleich aufgezeigt werden. Methodik Retrospektive Auswertung von Effizienzparametern aus 7, zwischen 2018 implementierten MR-Regionen. Analyse mit Chi-Quadrat-Test...

Background: Cranioplasty (CP) of autologous bone flap after decompressive craniectomy (DC) is known to be associated with a high complication rate, particularly resorption (BFR). In retrospective study, we used novel virtual reality (VR) visualisation technique identify and evaluate risk factors CP.Method: Twenty-five patients underwent early CP. All complications were recorded. Cranial computed tomography scans visualised via the VR software access fitting accuracy (bone size, gap width at...

in neurosurgery, delineation of tumor boundaries during resection brain tumors is substantial relevance. During operation distinction between and healthy tissue rely on the abilities surgeon based visual tactile differentiation. In this paper a high sensitivity actuator-sensor system using piezoelectric bimorph presented. Frequency shift transfer function bimorph's voltages are detected evaluated. Sensor's evaluated two frequency controls strategies: A phase-locked loop (PLL)...