A5102721046- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- Extracellular vesicles in disease
- Immune cells in cancer
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Gut microbiota and health
Jackson Laboratory
2023-2024
Nemours Children's Health System
2022
Cook Children's Medical Center
2016
Dupont Hospital
2015
Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none US Food and Drug Administration-approved adults.
The gut microbiome is increasingly recognized to alter cancer risk, progression and response treatments such as immunotherapy, especially in cutaneous melanoma. However, whether the influences immune checkpoint inhibitor (ICI) immunotherapy non-melanoma skin has not yet been defined. As squamous cell carcinomas (SCC) are closest proximity microbiome, we hypothesized that which regulates immunity, might affect SCC-associated anti-PD1 treatment response. We used ultraviolet radiation induce...
Identifying host genetic factors modulating immune checkpoint inhibitor (ICI) efficacy has been experimentally challenging because of variations in both and tumor genomes, differences the microbiome, patient life exposures. Utilizing Collaborative Cross (CC) multi-parent mouse resource population, we developed an approach that fixes genomic configuration while varying genetics. With this approach, discovered response to anti-PD-1 (aPD1) immunotherapy was significantly heritable four distinct...
Abstract BACKGROUND Head Start 4 is a randomized clinical trial to determine whether dose-intensive tandem consolidation, compared with single cycle, autologous hematopoietic progenitor cell rescue provides survival benefit in pediatric patients medulloblastoma or other embryonal tumors. The incorporates upfront molecular subgrouping and non-mandatory, prospective blood cerebrospinal fluid (CSF) collection. This pilot study aimed identify exosomal non-coding RNAs (exo-ncRNAs) that might...
Accumulating evidences suggest that recurrent tumors may acquire genetic abnormalities different from their treatment naive counterparts. Since surgery is rarely an option for terminal brain tumors, autopsy frequently the only chance to obtain therapy resistant tumor tissues. To determine and if (some) cells can survival postmortem anoxia/starvation identify seed repopulate orthotopic xenograft we collected 29 autopsied including 15 DIPGs, 7 GBMs, 4 medulloblastomas (MB), 2 ependymomas 1...
Brain tumors are the leading cause of cancer related death in children. Autopsy is frequently only chance to obtain tumor tissues and it remains unknown if autopsied can be used for model development. Thus we collected 30 brain tumors, including 15 diffuse intrinsic pontine gliomas (DIPG), 8 glioblastomas (GBM), 4 medulloblastomas (MB), 2 ependymoma 1 atypical teratoid/rhabdoid (ATRT), made following discoveries. i) A small fraction cells exhibited strong survival capacity remained viable,...
The gut microbiome is increasingly recognized to alter cancer risk, progression, and response treatments such as immunotherapy, especially in cutaneous melanoma. However, whether the influences immune checkpoint inhibitor (ICI) immunotherapy non-melanoma skin has not yet been defined. As squamous cell carcinomas (SCC) are closest proximity microbiome, we hypothesized that which regulates immunity, might affect SCC-associated anti-PD1 treatment response. We used ultraviolet radiation induce...