A5084064214- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Systemic Lupus Erythematosus Research
- Nephrotoxicity and Medicinal Plants
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Healthcare Systems and Public Health
- Autoimmune Bullous Skin Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Vasculitis and related conditions
- Heart Rate Variability and Autonomic Control
- Renal Transplantation Outcomes and Treatments
Klinička bolnica Merkur
2022-2025
University Hospital Centre Zagreb
2010-2024
University of Zagreb
2014-2024
Andrija Stampar Teaching Institute of Public Health
2024
Hrvatski zavod za javno zdravstvo
2016-2019
Croatian Institute of Transfusion Medicine
2017
College of Slavonski Brod
2016
Sisters of Charity Hospital
2016
Institute of Public Health Bengaluru
2016
University of Bologna
2016
Background Factor H-related protein 5 (FHR-5) is a member of the complement H family. Due to homology H, main regulator alternative pathway, it may also be implicated in pathomechanism kidney diseases where and pathway dysregulation play role. Here, we report first observational study on CFHR5 variations along with serum FHR-5 levels immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) C3 glomerulopathy (C3G) patients together clinical, genetic, complement, follow-up...
Abstract Background Acquired or genetic abnormalities of the complement alternative pathway are primary cause C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about presence and role C4nephritic factor(C4NeF) which stabilize classical C3-convertase. Our aim was to examine C4NeF its connection with clinical features other pathogenic factors. Results One hunfe IC-MPGN/C3G patients were enrolled study....
Abstract Background A novel data-driven cluster analysis identified distinct pathogenic patterns in C3-glomerulopathies and immune complex-mediated membranoproliferative glomerulonephritis. Our aim was to replicate these observations an independent cohort elucidate disease pathophysiology with detailed of functional complement markers. Methods total 92 patients clinical, histological, genetic data were involved the study, hierarchical done by Ward method, where four clusters generated....
Objective: The mechanisms that increase cardiovascular risk in individuals born small for gestational age (SGA) are not well understood. Telomere shortening has been suggested to be a predictor of disease onset. Our aim was determine whether impaired intrauterine growth is associated with early signs vascular aging and telomere length could biomarker this pathway. Methods: One hundred fourteen healthy young men SGA or after normal pregnancy [appropriate (AGA)] were enrolled. Patient data...
Improvements in agricultural practices Croatia have reduced exposure to consumption of aristolochic acid-contaminated flour and development endemic (Balkan) nephropathy. Therefore, it was hypothesized that Bosnian immigrants who settled an area 15-30 years ago would be at lower risk developing nephropathy because acid. To test this hypothesis, past present acid, proximal tubule damage as a hallmark nephropathy, prevalence CKD were analyzed.In cross-sectional observational study from 2005...
Abstract Background and Aims SGLT2 inhibitors, namely dapagliflozin, proved to slow progression of kidney disease in randomized clinical trials. Our aim was assess real world efficacy dapagliflozin on proteinuria level primary glomerulopathies (GN). Method adult patients with biopsy proven glomerulonephritis from all university hospitals Croatia who started as a standard care were enrolled. Data analyzed if had at least six months follow up. None the immunosuppression. are shown N (%) or...
Background: We have previously shown that metzincin protease ADAMTS-4 accompanies renal fibrogenesis, as it appears in the blood of hemodialysis patients. Methods: Native kidney (NKB) and transplant (TXCI) biopsy samples well plasma from patients with various stages CKD were compared to controls. In paired analysis, 15 TXCI their zero-time biopsies (TX0). Tissues evaluated scored (interstitial fibrosis tubular atrophy (IFTA) for NKB Banff ci TXCI). Immunohistochemical (IHC) staining BMP-1...
Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to arterial in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed identify any study related this topic. Therefore, our aim was determine the aRVH analyze whether stenting addition multifactorial drug therapy has beneficial effects on markers of clinical course.In 6-month longitudinal study, 37...
We analyzed correlation between ACE gene polymorphism and adaptive hypertrophic response of LV with regard to BP in competitive oarsmen. was determined using PCR method 52 oarsmen mean age 26 years (range 18–37) age, sex ethnically matched control group 34 persons. The mass echocardiographically calculated after Devereux. measured both mercury sphingomanometer Ambulatory Monitor SpaceLabs 90207. distribution was: 16 (47.1%) II, 12 (35.3%) ID, DD (17.6%); 8 (24%) 18 (52%) ID DD. frequency I...
Regardless of having a similar antihypertensive effect, different drug classes have effect on albuminuria. Patients with albuminuria will usually need more than one to achieve blood pressure control, particularly if the aim is also reduce Albuminuria independently associated cardiovascular and renal risk regardless diabetes status. The recent ESC/ESH guidelines listed microalbuminuria among hypertension-mediated organ damages. Albumin-to-creatinine ratio was suggested be included in routine...
The role of adiponectin in hypertension is still a matter debate. Obtained conflicting results could be mostly explained with diversity subjects included different studies. Our aim was to analyze association blood pressure (BP) group normotensive and untreated hypertensive subjects. Participants (N = 257) were selected from random sample 2487 enrolled an observational cross-sectional study. Subjects diabetes chronic kidney diseases excluded. BP measured using Omron M6 device following...
Our aim was to analyze whether birth weight contributes future hypertension through reduced kidney volume, and albuminuria could be a marker of this pathway. We included 103 patients with newly diagnosed essential 92 normotensive controls. Blood pressure (BP) measured using mercury sphygmomanometer ABP monitor. Kidney volume determined by ultrasound. Data on were obtained from mothers. Albuminuria in 24-hour urine samples. Hypertensive had lower higher than normotensives. There no difference...
<b><i>Background:</i></b> Varicella zoster virus (VZV) is distributed worldwide and highly contagious. In adults immunosuppressed patients of any age, the clinical course much more severe. The most severe complications are pneumonia (the main cause lethal outcomes in this infection), encephalitis, very rarely Reye syndrome hepatitis. <b><i>Case Presentation:</i></b> We present a 59-year-old man who came to emergency department due varicella...
Objective: Arterial stiffness (AS) is an independent risk factor of cardiovascular mortality in general and haemodialysis (HD) population. Endemic (Balkan) nephropathy (EN) a chronic tubulointerstitial salt wasting characterized with later onset arterial hypertension (AH) which could also affect AS. Thus our aim was to analyse AS EN patients compared other end-stage renal disease undergoing HD. Design method: A total 186 HD (90 m, 96 w; 67.35 + 13.07 years) from 3 dialytic units 2 endemic...
<h3>Objective</h3> Light chain deposition has been shown to be an important histologic hallmark with differences in isotype, characteristics and ratio of kappa lambda light chains having a significant role pathobiology, pathogenesis prognosis several glomerular diseases. However, there is, the best our knowledge, no study dedicated evaluating deposits patients lupus nephritis (LN). <h3>Methods</h3> We have conducted retrospective cohort evaluate prognostic significance profile kidney...
Abstract Background and Aims Complement alternative pathway disorders, atypical hemolytic-uremic syndrome (aHUS) C3 glomerulopathy (C3G), are rare diseases with a high rate of recurrence after kidney transplantation. Due to limited availability testing, patients may go undiagnosed, indicating testing during pretransplant evaluation. Posttransplant thrombotic microangiopathy (TMA) is complication A large number post transplant TMAs regarded as secondary, either immunosuppressive drugs or...