A5047830724- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Spectroscopy and Chemometric Analyses
- Genomics, phytochemicals, and oxidative stress
- Adenosine and Purinergic Signaling
- Cancer Mechanisms and Therapy
- Edible Oils Quality and Analysis
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Tuberculosis Research and Epidemiology
- Gestational Trophoblastic Disease Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Receptor Mechanisms and Signaling
- Adolescent and Pediatric Healthcare
- Neuropeptides and Animal Physiology
- Synthesis and Catalytic Reactions
Al-Azhar University
2020-2025
University of Bonn
2016-2024
University of Kufa
2023
Alexandria University
2019
In this study, a series of seven novel 2,4-dioxothiazolidine derivatives with potential anticancer and VEGFR-2 inhibiting abilities were designed synthesized as inhibitors. The compounds tested in vitro for their to inhibit the growth HepG2 MCF-7 cancer cell lines. Among tested, compound 22 (IC50 = 0.079 μM) demonstrated highest anti-VEGFR-2 efficacy. Furthermore, it significant anti-proliferative activities against 2.04 ± 0.06 1.21 0.04 M). Additionally, also increased total apoptotic rate...
Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful strategy for the development anti-inflammatory drugs that can avoid disadvantages using NSAIDs alone. Here, we report new pyridazine-based sulphonamides (5a-c 7a-f) potential multi-target candidates. First, furanone heterocycle in dual CA/COX-2 inhibitor Polmacoxib was replaced with pyridazinone one. Then, hydrophobic tail appended through benzylation 3-hydroxyl group scaffold to afford benzyloxy pyridazines...
Ectonucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of nucleoside tri- and di-phosphates to mono-phosphates. The products are subsequently hydrolyzed by ecto-5′-nucleotidase (ecto-5′-NT) nucleosides. NTPDase inhibitors have potential as novel drugs, e.g., for treatment inflammation, neurodegenerative diseases cancer. In this context, a series anthraquinone derivatives structurally related dye reactive blue-2 (RB-2), was synthesized evaluated human NTPDases...
The G protein-coupled receptor 17 (GPR17) is an orphan involved in inflammatory diseases. GPR17 antagonists have been proposed for the treatment of multiple sclerosis due to their potential induce remyelination. Potent, selective are required enable target validation. In present study, we describe discovery a novel class based on anthranilic acid scaffold. compounds' potencies were evaluated calcium mobilization and radioligand binding assays, structure–activity relationships analyzed....
The repeated usage of heating oils has been proven hazardous due to the degradation process by chemical reactions that lead changes in quality oil.There are numerous analytical methods which capable monitoring deterioration their deep fat frying processes.This work explores effect on physical behaviour soybean and rapeseed blends.Colour measurements, electrical impedance differential scanning calorimetry (DSC) were used for blends process.The results revealed all able respond oil with...
Phenols are well-known noxious compounds, which often found in various water sources.In this research, a new method was used to determine the total phenol and measure biological activity, by using microfluidic paper-based (µPAD), smartphone Sensor.It is portable, low-cost, environmentally friendly.The paper prepared filter cutting method.The reagent dried on paper.The color sensor of device as intensity samples through images captured software downloaded phone.The focus measured from RGB...