A5062666165- Nanoparticle-Based Drug Delivery
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Nanoparticles: synthesis and applications
- Synthesis and biological activity
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- Probiotics and Fermented Foods
- Natural product bioactivities and synthesis
- Helicobacter pylori-related gastroenterology studies
- Wound Healing and Treatments
- Antimicrobial agents and applications
- Graphene and Nanomaterials Applications
- Cancer therapeutics and mechanisms
- Child Abuse and Trauma
- Migration, Health and Trauma
- Intimate Partner and Family Violence
- Dental Erosion and Treatment
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Synthesis and Biological Evaluation
- Periodontal Regeneration and Treatments
- Seaweed-derived Bioactive Compounds
- Electrospun Nanofibers in Biomedical Applications
- Homelessness and Social Issues
City of Scientific Research and Technological Applications
2016-2025
University of Ottawa
2025
Biotechnology Research Institute
2025
University of California, Berkeley
2022
Indiana University
2020
Indiana University Bloomington
2019
Duke University Hospital
2019
Duke Medical Center
2019
Weill Cornell Medical College in Qatar
2016-2019
University of Pennsylvania
2019
A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids potential activity against VEGFR-2. The cytotoxic effects of synthesised derivatives Caco-2, HepG-2, MDA-MB-231 cell lines were investigated. Compound 12a found be most potent candidate investigated IC50 values 2, 10, 40 µM, respectively. Furthermore, tested in vitro for their VEGFR-2 inhibitory showing strong inhibition....
L-asparaginase is an important enzyme as therapeutic agents used in combination with other drugs the treatment of acute lymphoblastic leukemia. A newly isolated actinomycetes strain, Streptomyces sp. NEAE-82, was potentially producing extracellular L-asparaginase, it identified fradiae sequencing product deposited GenBank database under accession number KJ467538. purified from crude using ammonium sulfate precipitation, dialysis and ion exchange chromatography DEAE Sepharose CL-6B. Further...
The direct link between inflammatory bowel diseases and colorectal cancer is well documented. Previous studies have reported that some lactic acid bacterial strains could inhibit colon progression however; the exact molecules involved not yet been identified. So, in current study, we illustrated tumor suppressive effects of newly identified Lactobacillus acidophilus DSMZ 20079 cell-free pentasaccharide against cells. chemical structure purified was investigated by MALDI-TOF mass spectrum, 1D...
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects these compounds were estimated against A549, Caco-2, HepG2, MDA-MB-231. Compounds 13 14 showed comparable activities with doxorubicin Caco-2 cells. These strongly inhibited kinase activity. cytotoxic evaluated Vero Compound 7 highest value safety selectivity. Cell migration assay displayed ability compound to prevent healing abilities in cancer...
We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed their in vitro anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 MDA-MB-231. Compound 14a showed most potent effects lines (IC50 = 1.5 31.5 μM, respectively). Next, VEGFR-2 inhibitory activity, safety profiles selectivity indices examined all synthesized normal Vero line. (the safest member Caco-2 line) was further...
Curcumin (CU) is a natural polyphenolic phytoingredient. CU has anti-inflammatory, anti-oxidant, and anticancer activities. The poor solubility, bioavailability, stability of diminish its clinical application. Hence, structural modification highly recommended. analog; 3,5-bis(4-bromobenzylidene)-1-propanoylpiperidin-4-one (PIP) exhibited high stability, safety, more potent antiproliferative activity against hepatocellular carcinoma. In the present study, nano-bilosomes (BLs) were formulated...
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2 inhibitors. On a biological level, the in vitro ability obtained candidates to inhibit was found be strong with IC50 values range 76.64-175.50 nM. To investigate cytotoxicity safety, all compounds tested against panel four cancer cell lines (A549, Caco2, HepG2 MDA) well two normal (Vero WI-38). Interestingly, compound 12 exhibited noticeable A549, Caco2 MDA 5.40, 0.58 0.94 µM, respectively. These...
This study was conducted to investigate the antimicrobial-biofilm activity of chitosan (Ch-NPs), silver nanoparticles (Ag-NPs), ozonated olive oil (O3-oil) either separately or combined together against endodontic pathogens. While testing antimicrobial activity, Ch-NPs showed least minimum inhibitory concentration (MIC) and bactericidal (MBC) values exerting eightfold higher than O3-oil both Enterococcus faecalis Streptococcus mutans as well fourfold fungicidal Candida albicans....
Abstract Biosynthesis of gold nanoparticles (AuNPs) using algal polysaccharides is a simple, low-cost, and an eco-friendly approach. In the current study, different concentrations Arthospira platensis exopolysaccharides (EPS) were used to synthetize AuNPs via reduction ions. The biologically synthesized (AuNPs1, AuNPs2, AuNPs3) prepared in 3 forms through utilization three ratios EPS-reducing agents. analysis confirmed spherical shape EPS-coated AuNPs. Furthermore, by EPS l -ascorbic acid...
Bacterial infections are the key cause of death in patients suffering from burns and diabetic wounds while use traditional antibiotics has been growing steadily. Thus, present study, we trying to introduce a paradigm shift strategy improve chronic wound healing bacterial infection. To that end, have biologically synthesized silver nanoparticles (AgNPs) using Arthrospira sp polysaccharides, evaluated their antibacterial efficacy with safety pattern. Scanning electron micrographs showed...
Natural extracted ingredients are evolutionarily selected molecules and used to control inflammation, cancerous progression transformation. Several studies have evaluated the beneficial properties of certain pharmaceutical from Ficus carica (FC). The current study aimed investigate antioxidant anticancer FC ethanolic leaves extract. dried coarse powder F. was exhaustively with ethanol. resulting crude extract (FCE) assayed for total phenolic content and, activities, since both interrelated....
Abstract Background Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to metastasis chemotherapy resistance presence stem-like cells. We posited that natural polysaccharide known as 6-glucans, derived from Pleurotus ostreatus , could effectively counteract associated with cells breast cancer. Methods computationally developed a specific dual combinatorial therapy involving 6-glucans Paclitaxel (PTX) tested on...
New anticancer agents are continually needed because cancerous cells continue to evolve resistance the currently available chemotherapeutic agents. The aim of present study was screen, purify and characterize a hepatotoxic bacteriocin from Enterococcus species. production isolates achieved based on their antibacterial activity against indicator reference strains. showed broad spectrum by forming inhibition zones with diameters ranged between 12-29 mm. most potent produced strain molecularly...
Medicinal mushrooms have been used for centuries against cancer and infectious diseases. These positive biological effects of are due in part to the indirect action stimulating immune cells. The objective current study is investigate possible immunomodulatory mushroom polysaccharides on NK cells different In this study, fruiting bodies isolated from cultured Pleurotus ostreatus were extracted partially purified using DEAE ion-exchange chromatography. activation collected fractions Natural...