A5014014158- Myasthenia Gravis and Thymoma
- Synthesis and biological activity
- Synthesis and Catalytic Reactions
- Quinazolinone synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Enzyme function and inhibition
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Parkinson's Disease and Spinal Disorders
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Chronic Kidney Disease and Diabetes
- Skin Protection and Aging
- Pharmacology and Obesity Treatment
- Aluminum toxicity and tolerance in plants and animals
- Click Chemistry and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Mechanisms and Therapy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Antimicrobial agents and applications
- Chemotherapy-induced organ toxicity mitigation
- Tuberculosis Research and Epidemiology
- Vitamin K Research Studies
- Peptidase Inhibition and Analysis
King Khalid University
2019-2024
University of Khartoum
2012-2022
As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective inhibitors for carbonic anhydrase (CA) isoform II to find effective therapeutic agents glaucoma. Subsequently, the target synthesized and assessed their inhibitory action against cytosolic CA I II. Interestingly, molecules poorly inhibited while exhibiting low subnanomolar potency Compound
Gum Arabic (acacia Senegal) is a complex polysaccharide indigestible to both humans and animals. It has been considered as safe dietary fiber by the United States, Food Drug Administration (FDA) since 1970s. Although its effects were extensively studied in animals, there paucity of data regarding quantified use humans. This study was conducted determine regular (GA) ingestion on body mass index fat percentage among healthy adult females.A two-arm randomized, placebo controlled, double-blind...
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins examined for in vitro antitumor action on NCI-USA panel (58 tumour cell lines). Then, the most potent derivatives CA inhibitory towards physiologically relevant hCA isoforms I, II, tumour-linked IX isoform, addition, activity was evaluated. The failed to inhibit that could be...
The goal of this research was to augment the deposition caffeine loaded Transcutol® enriched cerosomes (TECs) gel for efficient topical treatment cellulite utilizing sonophoresis technique. Caffeine-loaded TECs were prepared using thin film hydration method applying 2
Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective an antioxidant flavonoid, can ameliorate chloride (CdCl2)-induced by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl2 (5 RH. All...
Thirteen components were identified in the methanol extract of Moricandia sinaica leaves (MSLE) through analysis utilizing HPLC-ESI-MS/MS., including flavonoids, anthocyanins, phenolic acids, and fatty acids. The M. contained total phenolics flavonoids (59.37 ± 2.19 mg GAE/g 38.94 2.72 QE/g), respectively. Furthermore, it revealed vitro antioxidant properties as determined by DPPH FRAP assays, with respective IC50 values 10.22 0.64 20.89 1.25 μg/mL. exhibited a notable hepatoprotective...
Non-alcoholic fatty liver disease (NAFLD) is associated with hepatic insulin resistance (IR). Resveratrol (RES) a potent hypolipidemic dietary polyphenol has been identified for its ability to prevent steatosis and IR in high-fat diet (HFD)-fed murine models of NAFLD. In the present study, we have carried an vivo animal experiment identify novel mechanism RES protective action. Sub-chronic (45 days) pretreatment 3 days HFD-fed adult Wistar rats prevented early through inhibiting PKC/JNK...
Doxorubicin (DOX), an anthracycline chemotherapy, plays a prominent role in the treatment of various cancers. Unfortunately, its nephrotoxic effects limit dosing and expose cancer survivors to increased morbidity mortality. This study examined nephroprotective eriodictyol, natural polyphenolic flavanone, DOX-treated rats molecular pathways involved. Forty adult were divided into five groups (8/group): Control; eriodictyol (20 mg/kg/day); DOX (2.5 mg/kg, twice/week); + Eriodictyol;...
Abstract New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides ( 6a–m and 8a–d ) were designed synthesized to potentially inhibit both the epidermal growth factor receptor (EGFR) carbonic anhydrase (CA), with anticancer properties. First, in vitro activity of each target substance was tested using Henrietta Lacks cancer cell line M.D. anderson metastasis breast cells. Then, possible CA inhibition against human isoforms I, II, IX investigated, together EGFR inhibitory activity, most powerful...
Transforming growth factor-β1 (TGF-β1), endothelin-1 and angiotensin II are responsible for extracellular matrix accumulation within the kidney in diabetic nephropathy.This study evaluated effect of adding Gum Arabic (GA) insulin on serum glucose, renal function, TGF-β1, endothelin-1, rats with nephropathy.Sixty male Sprague-Dawley were divided into; normal, normal plus GA, (DM), DM insulin, GA groups. Levels glucose creatinine serum, II, homogenate HbA1c measured.Serum creatinine, increased...
Abstract Background Antimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 human) is one two major classes AMPs humans. The upregulation synthesis a novel non-antibiotic approach to prevent or treat infectious diseases. Butyrate was found induce Cathelicidin expression. Gum Arabic (GA), an exudate from Acacia senegal tree, known for its prebiotic effects. Fermentation GA by colonic bacteria increases serum butyrate...
Fever of unknown origin (FUO) is a medical term describing fever that lasts for at least three weeks without diagnosis being reached after extensive diagnostic evaluation. Therefore, this study aimed to identify the common pathogens causing FUO in patients admitted Abbasia Hospital Egypt from January 2020 December 2022, their antimicrobial susceptibility profiles, and associated resistance genes. The also investigate burden multidrug-resistant (MDR) priority nominated by World Health...
This study investigated if EX-527 has an anti-tumour effect in SKOV-3 and OVCAR-3 ovarian cancer (OC) cell lines this involves the SIRT1/NF-κB axis. Cells were cultured presence or absence of EX-527, a selective SIRT-1 inhibitor. Exendin-4 significantly induced death both inhibited migration invasion. Also, it decreased protein levels Bcl-2, MMP-9, ICAM-1 increased those Bax, cyclin D1 cleaved caspase-3. Mechanistically, activity nuclear accumulation SIRT1 NF-κB p65; acetylated p65,...
Solar ultraviolet radiation (UVR) constitutes a significant hazard to the skin because of its direct carcinogenic action and immunosuppressive action, which are mostly attributed B (UVB) component. Evidence suggests that A (UVA) in natural sunlight might neutralize damaging effect UVB. We aimed at evaluating systemic immunological impacts exposure either (sun UVR) or The experiment included five groups mice: unexposed control group; two animals were daily exposed 30 min sun UVR for 4 days...
This study evaluated the antiplatelet effect of plant carotenoid, astaxanthin (ASTX) in rats fed either control or high cholesterol plus cholic acid diet (HCCD) and possible underlying mechanisms. Adult male Wistar were divided into four groups (n = 8/each), namely, (fed normal diet), + ASTX (10 mg/kg/day), HCCD-fed rats, HCCD ASTX-treated rats. Diets treatments orally administered daily for 30 days. In both significantly increased fecal levels triglycerides cholesterol, reduced platelet...
Activation of autophagy suppresses ovarian cancer (OC). This in vitro study investigated whether the anti-tumour effect exendin-4 against OC involves modulation and figured out possible mechanisms action. SKOV-3 OVCAR-3 cells (1 × 105/ml) were cultured DMEM medium treated with presence or absence chloroquine (CQ), an inhibitor. In some cases, also exendin- 4 without pre-treatment compound C (CC), AMPK inhibitor, insulin-like growth factor (IGF-1), a PI3K/Akt activator. Exendin-4 increased...
This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, oxidative stress in a rat model diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, normal+AS, (DM), DM+insulin, DM+AS, DM+insulin+AS groups. Diabetes mellitus (type 1) was induced by single injection streptozotocin (65 mg/kg), AS treatments carried until culled at end week 12. Serum glucose...
This study investigated the effect of Astaxanthin (ASTX) on levels and activities clotting factors in control rats. Untreated or ASTX-treated rats (10 mg/kg, dissolved DMSO) were used this study. ASTX treatment was conducted for 10 days daily. significantly decreased platelet count prolonged values prothrombin activated partial thromboplastin time (PT aPTT, respectively). Besides, it reduced serum vitamin K plasma hepatic expression K-dependent (FII, FVII, FIX, FX) without altering all other...