About
Contact & Profiles
A5100660653
Research Areas
- Synthesis and biological activity
- Enzyme function and inhibition
- Crystallization and Solubility Studies
- Melanoma and MAPK Pathways
- Cancer therapeutics and mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Cancer Mechanisms and Therapy
- Synthesis and Catalytic Reactions
- Cytokine Signaling Pathways and Interactions
- X-ray Diffraction in Crystallography
Tanta University
2023-2025
As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective inhibitors for carbonic anhydrase (CA) isoform II to find effective therapeutic agents glaucoma. Subsequently, the target synthesized and assessed their inhibitory action against cytosolic CA I II. Interestingly, molecules poorly inhibited while exhibiting low subnanomolar potency Compound
10.1021/acs.jmedchem.3c02279
article
EN
Journal of Medicinal Chemistry
2024-01-11
10.1016/j.bioorg.2024.107843
article
EN
Bioorganic Chemistry
2024-09-24
10.1016/j.bioorg.2025.108391
article
EN
Bioorganic Chemistry
2025-03-01
10.1016/j.ejmech.2023.115675
article
EN
European Journal of Medicinal Chemistry
2023-07-23
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