A5045223632- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Liver Disease Diagnosis and Treatment
- Ginger and Zingiberaceae research
- Tryptophan and brain disorders
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Asthma and respiratory diseases
- Cholinesterase and Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Cardiac Ischemia and Reperfusion
- Tea Polyphenols and Effects
- Cardiac Fibrosis and Remodeling
- Medical Education and Admissions
- Morinda citrifolia extract uses
- Evaluation of Teaching Practices
- Effects of Radiation Exposure
- Flavonoids in Medical Research
- Chemotherapy-induced organ toxicity mitigation
- Fungal Biology and Applications
- Advances in Cucurbitaceae Research
- Phytochemical and Pharmacological Studies
University of Hafr Al-Batin
2021-2025
Northern Border University
2018-2023
MCPHS University
2022
Oxidative stress and inflammation are key components in cardiovascular diseases heart dysfunction. Herein, we evaluated the protective effects of (+)-taxifolin (TAX), a potent flavonoid with significant antioxidant anti-inflammatory actions, on myocardial oxidative tissue injury, inflammation, cell death, using mouse model isoproterenol (ISO)-induced acute injury. Mice were given TAX (25 50 mg/kg, orally) for 14 days before receiving two subsequent injections ISO (100 s.c.) at an interval 24...
Taxifolin (TA) is a natural flavonoid found in many foods and medicinal plants with well-documented antioxidant anti-inflammatory properties. Cyclophosphamide (CP) an effective antineoplastic immunosuppressive agent; however, it associated numerous adverse events, including hepatotoxicity. Herein, we aimed to investigate the potential protective effects of TA using mouse model CP-induced Mice were co-treated (25 50 mg/kg, orally) CP (30 i.p.) for 10 consecutive days sacrificed 24 hours...
Conjunctivitis is considered as a common infection of ocular surfaces. Eye drop most commonly used for treatment conjunctivitis, but has some drawback like 95% drug eliminated after administration. Administration levofloxacin to the anterior site in form chitosan coated poly (lactic-co-glycolic acid) nanoparticles (LFV-CS-PLGA-NPs) expected overcome these problem and increasing corneal contact time permeability effective bacterial conjunctivitis. The Nanoparticles were developed by single...
Herbal drugs are being used by traditional systems of medicine in liver damage. Thus, the designed objective was to evaluate hepatoprotective activity ethanolic extract Pterocarpus marsupium Roxb. leaves (EEPM) against paracetamol-induced damage (PILD) SD rats. Group-I rats were administered with 1 ml 1% CMC/kg b.wt per day for 8 days. Group-II body wt. till 7th day, then 3 g paracetamol/kg on eighth day. Groups-III, IV and V animals pretreated 200 mg EEPM/kg/day, 400 100 silymarin/kg/day...
Emerging investigations have indicated that many plant polysaccharides may be beneficial for treating metabolic diseases. To date, the therapeutic efficacy and potential toxicity of extracted from Clinacanthus nutans (C. nutans) remain unexplored. This study investigated in vivo acute subacute oral toxicological profiles highest doses C. bioactive (CNBP) leaves using conventional methods. The total 39 healthy 8–10 weeks male Sprague-Dawley rats (n = 3) were randomly assigned to control (C),...
Chitosan derivatives are reported as anticoagulants in the literature. This work was undertaken to develop novel chitosan anticoagulants. The sulfonated of were formed by reaction with chlorosulfonic acid N,N-dimethylformamide. structures these established FTIR and 1H NMR spectra. prepared evaluated for their vivo anticoagulant effects tail bleeding method Wistar rats utilizing nicoumalone a standard drug. results revealed that sulfonation increases its activity. developed compounds...
Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit most famous in indigenous systems of medicine. The present research work aims to appraise validate the potential polyphenol-rich star tea (SAT) on oxidative stress, obesity related biochemical parameters high-fat-sugar-diet (HFSD)-induced model rats. SAT was prepared using traditional method warm water. Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis performed for simultaneous...
In the present research study, we formulate bilosomes (BMs) of diclofenac (DC) for oral delivery enhancement therapeutic efficacy (anti-inflammatory disease). The BMS were prepared by thin film hydration method and optimized Box−Behnken design (BBD) using cholesterol (A), lipid (B), surfactant (C), bile salt (D) as formulation factors. Their effects evaluated on vesicle size (Y1) entrapment (Y2). DC-BMs-opt showed a 270.21 ± 3.76 nm, PDI 0.265 0.03, efficiency 79.01 2.54%. DSC study result...
Geraniol (GER) is a plant-derived acyclic isoprenoid monoterpene that has displayed anti-inflammatory effects in numerous vivo and vitro models. This study was therefore designed to evaluate the antiarthritic potential of GER complete Freund's adjuvant (CFA)-induced inflammatory arthritis (IA) model rats. IA induced by intraplantar injection CFA (0.1 mL), week after administration, rats were treated with various doses methotrexate (MTX; 1 mg/kg) or (25, 50, 100 mg/kg). Treatments given on...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing immense suffering for the patients. Dopamine D2 and 5-hydroxytryptamine receptor 1A (5-HT1A) receptors' activation has been reported to play crucial role in managing neurological outcomes brain other health disorders. This study aimed investigate of aripiprazole, dopamine 5-HT1A selective activator, restoration memory deficit induced by streptozotocin mice. The cognitive functions animals were determined using...
Background: The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity a rat model following high‐fat‐sugar diet (HFSD). Methods: MPT was prepared through customary method decoction subjected to analysis for its composition using reversed‐phase high‐performance liquid chromatography (RP‐HPLC). Two specific doses MPT, namely, 250 500 mg/kg body weight (BW), were chosen study—referred as MPT‐250 MPT‐500,...
Background and Objectives: Citrullus colocynthis belongs to the Cucurbitaceae family is a wild medicinal plant used in folk literature treat various diseases. The purpose of current study was explore antihypertensive antioxidant potentials (CC) polyphenol-rich fractions using spontaneous hypertensive rat (SHR) model. Materials Methods: concentrated aqueous ethanol extract CC fruit successively fractioned solvents increasing polarity, i.e., hexane, chloroform, ethyl acetate n-butanol....
Leptadenia pyrotechnica Forssk. Decne is a member of family Apocynaceae and locally known as 'Khipp'. It found in dry, sandy habitat Pakistan several other regions around the world including Asia, Tropical Africa, Western Gulf Mediterranean countries. has nutritional value, containing 4 % lipids, 23 proteins, 28 carbohydrates, fibers, vitamin E minerals. Traditionally, this plant been used by communities for pain, different inflammatory kidney disorders. Ethno-botanical studies have reported...
Burn injuries are among the most common accidental health problems worldwide, frequently leading to and socio-economic challenges. Despite this, no standard protocol for managing burn can overcome adverse effects of currently used drugs. The present study sets out develop evaluate efficacy new herbal ointments in providing synergistic anti-inflammatory, antimicrobial, antioxidant, cell-proliferating activities. It also investigates high-performance liquid chromatography (HPLC)...
With the expansion in pharmacy education Saudi Arabia, there is a pressing need to maintain quality assurance programs using several tools. The progress test formative assessment tool that can serve provide information all stakeholders. This study evaluated results of unified was shared among 15 colleges pharmacy.The composed 100 MCQs where 30% which cover basic pharmaceutical sciences and 70% practice. questions were collected from participated test. administered online undergraduate...
In the present study, we have investigated and/or compared role of glibenclamide, G as cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, and lubiprostone, L chloride channel-2 (ClC-2) activator in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced gastrointestinal inflammation. GI inflammation was induced by intrarectal administration DNBS. Rats were randomly allocated 5 groups sham control, distilled water + DNBS, sulfasalazine (S) All pre-treated successively for five days...