A5051920455- Aquaculture disease management and microbiota
- Chemotherapy-induced organ toxicity mitigation
- Marine Bivalve and Aquaculture Studies
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Invertebrate Immune Response Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Cardiac Ischemia and Reperfusion
- Vitamin D Research Studies
- Pharmacological Effects of Natural Compounds
- Parasite Biology and Host Interactions
- Nitric Oxide and Endothelin Effects
- Forensic Entomology and Diptera Studies
- Chronic Kidney Disease and Diabetes
- Environmental Toxicology and Ecotoxicology
- Aquaculture Nutrition and Growth
- Vitamin C and Antioxidants Research
- Pomegranate: compositions and health benefits
- Ocular Surface and Contact Lens
- Biotin and Related Studies
- Genetic and Environmental Crop Studies
- Nephrotoxicity and Medicinal Plants
- Dietary Effects on Health
- Paraoxonase enzyme and polymorphisms
University of Hafr Al-Batin
2020-2025
Al-Hussein Bin Talal University
2010-2023
Macquarie University
2007-2010
Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical application limited because of multi-organ toxicity. Galangin (Gal) bioactive flavonoid with promising biological activities. This study investigated the hepatoprotective effect Gal in CP-induced rats. Rats received (15, 30 and 60 mg/kg/day) for 15 days followed by single dose CP at day 16. triggered liver injury characterized elevated serum transaminases, alkaline phosphatase (ALP) lactate dehydrogenase...
Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nrf2/HO-1) signaling. Rats received FN (10, 20, 40 mg/kg) for 10 days single dose day 7. induced was characterized by increased serum creatinine urea, molecule-1 (Kim-1), several histological alterations....
Cardiovascular complications are the leading cause of morbidity in diabetes. Oxidative stress and inflammation implicated development progression diabetic cardiomyopathy (DCM). This study explored cardioprotective effect galangin (Gal), a natural flavonoid with radical-scavenging anti-inflammatory activities, rats. An experimental rat model was achieved by single injection 50 mg/kg streptozotocin. Gal (15 mg/kg) administered daily for six weeks samples were then collected. Diabetic rats...
The role of oxidative injury and inflammatory response in cardiovascular diseases heart failure has been well-acknowledged. This study evaluated the protective effect umbelliferone (UMB), a coumarin with promising radical scavenging anti-inflammatory activities, on myocardial induced by isoproterenol (ISO) rats. Rats received 50 mg/kg UMB orally for 14 days 85 ISO twice at an interval 24 h. Administration elevated serum troponin I, creatine kinase-MB lactate dehydrogenase, caused...
Liver injury is among the adverse effects of chemotherapeutic agent cyclophosphamide (CP). This study investigated protective role flavone apigenin (API) against CP-induced liver damage, pointing to involvement Nrf2/HO-1 signaling. Rats were treated with API (20 and 40 mg/kg) for 15 days received CP (150 on day 16. caused damage manifested by an elevation transaminases, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), histological alterations, including granular vacuolation,...
Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity. Formononetin (FN) potent flavonoid that exhibits numerous promising pharmacological activities. In this study, we have assessed the nephroprotective efficacy of FN against GEN-induced renal injury in rats. Rats were orally administered with (60 mg/kg/day, for 2 weeks) and co-treated intraperitoneal (i.p.) injection GEN (100 mg/kg/day) during days 8-14. GEN-treated rats demonstrated increased urea creatinine...
Oxidative stress and inflammation are key components in cardiovascular diseases heart dysfunction. Herein, we evaluated the protective effects of (+)-taxifolin (TAX), a potent flavonoid with significant antioxidant anti-inflammatory actions, on myocardial oxidative tissue injury, inflammation, cell death, using mouse model isoproterenol (ISO)-induced acute injury. Mice were given TAX (25 50 mg/kg, orally) for 14 days before receiving two subsequent injections ISO (100 s.c.) at an interval 24...
Taxifolin (TA) is a natural flavonoid found in many foods and medicinal plants with well-documented antioxidant anti-inflammatory properties. Cyclophosphamide (CP) an effective antineoplastic immunosuppressive agent; however, it associated numerous adverse events, including hepatotoxicity. Herein, we aimed to investigate the potential protective effects of TA using mouse model CP-induced Mice were co-treated (25 50 mg/kg, orally) CP (30 i.p.) for 10 consecutive days sacrificed 24 hours...
Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress inflammation, limiting clinical use. Herein, we looked into the effect of punicalagin (PU), a polyphenolic molecule having variety health-promoting attributes, on MTX-induced hepatotoxicity mice. PU (25 50 mg/kg/day) was given orally mice for 10 days, while single dose MTX (20 mg/kg) injected...
The present study explored the antihyperlipidemic potential of a standardized methanolic extract Averrhoa carambola (A. carambola) leaf (MEACL) in high-fat diet (HFD)-fed rats. MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, mass index (BMI), daily food intake, relative organ weight, histology liver were evaluated. In addition, effect on HMG-CoA reductase pancreatic lipase...
Oxidative tissue injury and inflammatory responses play major roles in cardiovascular diseases heart failure. Visnagin (VIS) is a natural bioactive component of Ammi visnaga, with promising radical scavenging anti-inflammatory activities. This study explored the protective effect VIS against isoproterenol (ISO)-induced acute myocardial oxidative stress rats. was supplemented for 14 days, rats received ISO (100 mg/kg) twice at an interval 24 h. ISO-induced characterized by elevated serum...
Purpose: To determine the status of glycemic control and its associated factors among adult patients with type 2 diabetes mellitus (T2DM) in Hodeidah City, Yemen.
 Methods: This cross-sectional study involved T2DM attending an outpatient clinic at Military Hospital Hodeidah, from January to March 2017. Relevant socio-demographic characteristics, clinical self-management behaviours were recorded face-to-face interviews. Blood pressure, body weight, height measurements also obtained....
In this work an attempt was performed to investigate the in vitro ability of Lucilia sericata maggots control fungi involved superficial fungal infections. A novel GFP-modified yeast culture enable direct visualization ingestion cells by maggot larvae as a method used. The obtained results showed that yeasts were successfully ingested and 1mg/ml excretions/ secretions (ES) considerable anti-fungal activity against growth Trichophyton terrestre mycelium, radial inhibition after 10 days...
Inflammation is a physiological reaction of the immune system required to remove presence pathogenic germs. Many herbal-derived extracts and phytoconstituents show anti-inflammatory effects. Among these natural Ephedra alte (E. alte), which shows pepsin enzyme inhibitory, antibacterial, antioxidant activities. In this work, molecular docking study conducted on five major human cytokines receptors (IL-6, hybrid TLR4, TNF-α, IL-1β, extracted TLR4) explore recognition process complex...