A5086617764- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plant Extracts Effects
- Cytokine Signaling Pathways and Interactions
- Diet, Metabolism, and Disease
- Animal testing and alternatives
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Contact Dermatitis and Allergies
- Phytochemicals and Antioxidant Activities
- T-cell and B-cell Immunology
- Immunotoxicology and immune responses
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Pharmacological Effects of Medicinal Plants
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Medicinal Plants and Neuroprotection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Morinda citrifolia extract uses
- Phytochemistry and Bioactive Compounds
University of Lahore
2020-2025
National Institute of Technology
2025
Capital University of Science and Technology
2023-2024
Center for Experimental and Clinical Infection Research
2018-2022
Helmholtz Centre for Infection Research
2018-2022
University of Sargodha
2013-2022
Medizinische Hochschule Hannover
2020
Centre for Individualised Infection Medicine
2018
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
Most monogenic disorders have a primary clinical presentation. Inherited ISG15 deficiency, however, has manifested with two distinct presentations to date: susceptibility mycobacterial disease and intracranial calcifications from hypomorphic interferon-II (IFN-II) production excessive IFN-I response, respectively. Accordingly, these patients were managed for their infectious neurologic complications. Herein, we describe five new six novel mutations presenting skin lesions who dermatologic...
Abstract Background Congenital ISG15 deficiency is a rare autoinflammatory disorder that driven by chronically elevated systemic interferon levels and predominantly affects central nervous system skin. Methods results We have developed induced pluripotent stem cell‐derived macrophages endothelial cells as model to study the cellular phenotype of identify novel treatments. –/– exhibited expected hyperinflammatory responses, but normal phagocytic function. In addition, they displayed...
Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an agent against glioblastoma (GBM). Network pharmacology analysis was employed identify targets of CT. A comprehensive data mining carried out assess CT and GBM-associated target genes. Protein-protein interaction network constructed hub genes later GO KEGG enrichment performed elucidate the...
Desa Ciherang, yang terletak di Kabupaten Bandung, menghadapi tantangan pengelolaan limbah rumah tangga dan bonggol jagung sebagai pertanian utama. Permasalahan ini diperparah oleh rendahnya tingkat pendidikan penduduk tingginya pengangguran usia produktif, menghambat pemanfaatan menjadi sumber daya ekonomis. Untuk mengatasi hal ini, penelitian mengembangkan sistem digitalisasi berbasis aplikasi mobile bernama Pulus. Sistem dirancang untuk mendukung proses daur ulang dengan menyediakan...
Abstract A series of systemic toxicity tests for various types compounds are presented with illustrative data and discussed in regard to their relevance as potential screening dental products. In developing marketing a new material, it is important not only ensure safety the patient but also dentist, assistant, laboratory worker who routinely handles uses product. Data on number commercially available products well chemical entities, which were tested by one or more methods described.
Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent ulcers that healed scar formation upon corticosteroid treatment. Both had homozygous nonsense mutation in the gene, leading to unstable protein lacking functional domain. characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and induced pluripotent stem cell-derived vascular...
Geraniol (GER) is a plant-derived acyclic isoprenoid monoterpene that has displayed anti-inflammatory effects in numerous vivo and vitro models. This study was therefore designed to evaluate the antiarthritic potential of GER complete Freund's adjuvant (CFA)-induced inflammatory arthritis (IA) model rats. IA induced by intraplantar injection CFA (0.1 mL), week after administration, rats were treated with various doses methotrexate (MTX; 1 mg/kg) or (25, 50, 100 mg/kg). Treatments given on...
Citronellol has been reported to have anti-inflammatory, anti-cancer, and antihypertensive activities, but its effect on myocardial ischemia is still unclear. The aim of this study was investigate the therapeutic effects pharmacological mechanisms citronellol ischemia. Therefore, a rat model established using doxorubicin (DOX) model. To induce cardiotoxicity, rats were given DOX (2.5 mg/kg) intraperitoneally over 14-day period. Group I served as control received tween 80 (0.2%), group II...
The arabinoxylan from Ispaghula (Plantago ovata) husk has been proven scientifically as potential excipient. However, toxicity study of the is still lacking. present was done to investigate acute in two animal species.The mice were exposed (1 g/kg, 5 10 g/kg) and rabbits (2.5 orally observed for a period 14 days. On day 15 hematology, serum biochemistry necropsy performed relative organ weight calculated histological examination carried out. Primary dermal eye irritation tests Cardiac...
The current study was designed to determine pulegone’s antihypertensive and vasoprotective activity in L-NAME-induced hypertensive rats. Firstly, the hypotensive dose-response relationship of pulegone evaluated normotensive anesthetized rats using invasive method. Secondly, mechanism involved determined presence pharmacological drugs such as atropine/muscarinic receptor blocker (1 mg/kg), L-NAME/NOS inhibitor (20 indomethacin/COX (5 mg/kg) Furthermore, studies were carried out assess...
Purpose: To determine the major reasons, sources, diseases and drugs responsible for increasing trend of self-medication.Method: A community-based cross-sectional survey was carried out in district Faisalabad Pakistan. Respondents (1488) were classified on basis age, sex, education, lifestyle their economical level. questionnaire distributed among sample population to collect data.Results: Majority respondents involved self-medication aged between 15 20 years. Family members (N = 717, 48 %)...
Boswellic acids, derived from the Boswellia serrata plant, have been demonstrated to anti-inflammatory properties in experimental animal models. The present study was aimed evaluate uro-protective effect of boswellic acids rats with cyclophosphamide-induced cystitis. Interstitial cystitis induced by cyclophosphamide (CYP). In order analyze reduction urothelial damage, bladder weight, nociception response, and Evans blue dye extravasation were evaluated. To investigate involvement lipid...
This study was designed to explore the antihyperlipidemic effects of amino acid derivatives 2-mercaptobenzimidazole (4J and 4K) in high-fat diet (HFD)-fed rats.Male Sprague-Dawley rats were divided into nine groups which received either standard or HFD for 28 days. Blood samples taken on 27th day from HFD-fed ensure hyperlipidemia. HFD-induced hyperlipidemic later daily dosing vehicle simvastatin (SIM; 20 mg/kg) 4J/4K compounds (10, 20, 30 12 consecutive On 40th day, animals sacrificed,...
Background: Geranyl acetate, a compound found in plant oils, has been studied for its potential effects on renal and cardiovascular ailments. Objective: This study aimed to investigate the diuretic anti-hyperuricemic properties of geranyl acetate male Wistar rats using hyperuricemia-induced rat model. Methods: Molecular docking studies were conducted assess acetate's interactions with various targets. vitro performed evaluate scavenging ability inhibition xanthine oxidase, urease,...
Purpose: To investigate the hypotensive potential of Berberis orthobotrys Bien Ex Aitch (Family: Berberidaceae) in both normotensive and hypertensive rats.Methods: Aqueous-methanol (70:30) extract at doses 25, 50, 75 100 mg/kg was evaluated for its effect on blood pressure heart rate using non-invasive measuring apparatus. After initial screening, dose that produced a maximum selected antihypertensive study. Median lethal (LD50) sub-chronic toxicity were also determined. Various biochemical...