A5068033206- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Ultrasound and Hyperthermia Applications
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Appendicitis Diagnosis and Management
- Surfactants and Colloidal Systems
- Cancer, Hypoxia, and Metabolism
- Analytical Chemistry and Chromatography
- Ultrasound and Cavitation Phenomena
- Energetic Materials and Combustion
- Polydiacetylene-based materials and applications
- Cancer Genomics and Diagnostics
- Biological Research and Disease Studies
- Genetics and Neurodevelopmental Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Pharmacological Effects and Assays
- Neurogenesis and neuroplasticity mechanisms
- Cancer Research and Treatment
- Fecal contamination and water quality
- Magnesium in Health and Disease
- Cerebral Venous Sinus Thrombosis
- Folate and B Vitamins Research
- Ocular Surface and Contact Lens
King Saud bin Abdulaziz University for Health Sciences
2024
King Abdullah International Medical Research Center
2024
National Guard Health Affairs
2024
King Abdulaziz Medical City
2024
Prince Mohammed bin Abdulaziz Hospital
2024
University of Toronto
2024
Cairo University
2013-2022
Sebha University
2016
Khartoum International Institute for Arabic Languague
2016
University of Khartoum
2016
Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility hepatic metabolism require development of delivery systems able improve its bypass effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NLCs) were prepared characterized. AT-NLCs by emulsification using high-speed homogenization followed ultrasonication. The NLCs showed particle size between 162.5 ± 12 865.55 28 nm while zeta potential values...
<h3>Background:</h3> Autosomal recessive primary microcephaly (MCPH) is a model disease to study human neurogenesis. In affected individuals the brain grows at reduced rate during fetal life resulting in small but structurally normal and mental retardation. The condition genetically heterogeneous with mutations <i>ASPM</i> being most commonly reported. <h3>Methods results:</h3> We have examined this further by studying three cohorts of microcephalic children extend both phenotype mutation...
The active compounds present in Hypericum perforatum L. (Hypericaceae) include hyperforin, hypericins and flavonoids, which are assumed to be responsible for the activity of extract treatment wounds scars. study aimed incorporate H. standardized a known content phloroglucinols, naphthodianthrones polyphenolic into an effective transdermal drug delivery system capable entrapping both lipophilic hydrophilic constituents form niosomal gels wound treatment. An 80% ethanol (HE) was prepared on...
Purpose: Development of hyaluronic acid conjugated metformin-phospholipid sonocomplexes (HA-MPS), a biphasic complexation product compiled for enhancing both the lipophilicity and targeting potential Metformin (MET) to CD44 receptors on pancreatic cancer. Methods: MET was chemically (HA) via amide coupling reaction. Then, HA physically Lipoid™S100 ultrasound irradiation. A combined D-optimal design implemented statistically optimize formulation variables. The HA-MPS were characterized...
Clonazepam (CP) is a potent long-acting nitrobenzodiazepine derivative that could be used for targeting peripheral benzodiazepine receptors. Phospholipid magnesome new vesicular nanosystem recently developed brain targeting. Improving the uptake of 131I-CP to might effective diagnosis and/or radiotherapy certain diseases tumors.CP was radiolabeled with 131I using direct electrophilic substitution reaction. Quality control performed different techniques. Different formulas were prepared and...
The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as model drug. engineering system had two stages, the first stage tuning MSP physicochemical properties by complexation with pure phosphatidylcholine or phosphatidylinositol enriched soybean lecithin form MSP-phospholipid complex (MSP-PLCP). Changes in were assessed optimum MSP-PLCP formula then used formulation into flushing resistant mucoadhesive polymers;...
The anti-hyperglycemic sodium glucose co-transporter 2 inhibitor Canagliflozin (CFZ) represents a recent antihyperglycemic modality, yet it suffers from low oral bioavailability. current work aims to formulate CFZ-loaded transdermal nanostructured liquid crystal gel matrix (NLCG) improve its therapeutic efficiency. Pre-formulation study included the construction of pseudoternary phase diagrams explore effect two conventional amphiphiles against amphiphilic tri-block copolymer in formulation...
Rituximab (RTX) and recombinant human myelin basic protein (rhMBP) were proven to be effective in ameliorating the symptoms of multiple sclerosis (MS). In this study, a nanoformulation containing rhMBP with RTX on its surface (Nano-rhMBP-RTX) was prepared investigated comparison other treatment groups determine potential neuro-protective effects C57BL/6 mice after inducing experimental autoimmune encephalomyelitis (EAE).EAE induced corresponding by injecting 100 μL an emulsion complete...
Objectives: The paradox of concurrent coronary artery disease (CAD) among patients with rheumatic and non-rheumatic valvular heart (RVHD; non-RVHD) is unclear. We aimed to evaluate the impact RVHD non-RVHD on prevalence CAD various risk factors, assess number diseased coronaries, clinical profile possible predictors in these patients, which may clarify provide an insight for prevention CAD. Methods: records 106 who had undergone valve replacement surgery at King Faisal Cardiac Centre from...
Background: Appendicitis is a common diagnostic challenge in pediatric patients. Based on clinical and laboratory findings, the modified Alvarado scoring system (MAS) commonly used to assess likelihood of appendicitis. This study aims evaluate performance MAS compared radiologic findings its components diagnosis appendicitis children. Methods: retrospective involved 177 patients with abdominal pain. The MAS, examinations (ultrasound), physical examination were evaluated. Data sensitivity,...
Ochratoxin A (OTA), the mycotoxin produced by species of Aspergilli, specifically Aspergillus carbonarius and ochraceus, Penicillium verrucosum have harmful effects on humans, animals, crops that result in illnesses economic losses. Therefore, this study has been undertaken cytotoxic ochratoxin four moulds extracts which used two human cell lines(Hfl-1 Hep-2). Control experiment (uncontaminated solid substrate extract) showed negligible both lines after 72 hr exposure. All mould (OTA)...
Toxicological effects of Ambrosia maritima in Nubian goatsMelon Toxicity Indigenous plant was investigated.Twenty fore, 6-8 month old, 12 female and male Sudanese goats were used.Dried Leaves powder mixed with water given orally by drench to the animals at a dose 1000 or 2000mg/kg/day for 126 days.Two females drenched 1000mg/ kg/day, died day 8 9 post treatment one 2000/kg/day 13.The results revealed that days, showed chronic toxicity evident clinical symptoms, pathological biochemical...
In many applications, a constant thrust of the solid propellant rocket motor (SPRM) throughout operating time is desired.Such thrust-time scenario known as neutral burning.Typically, tubular grains with internal burning surface yield progressive history and, therefore, if required, progression in should be compensated by including side faces well.However, neutrality grain that burns at both and end surfaces subject to limited range slenderness ratio.Tapering port would expand ratio ensures...
Magnesium is the second most abundant intracellular cation and fourth in body. Clinical manifestations of hypomagnesaemia include neuromusclar, neurological, psychiatric cardiac arrhythmias including torsade de pointes resulting sudden death. Incidence hospitalised patients common there a lack clinical awareness. Clinicians should become familiar with conditions therapeutics that are risk factors for underlying magnesium replacement regimens. Two who suffered fatal complications whom was an...
OBJECTIVES: To compare the predictors of 30 days mortality in elderly subjects (Ͼ 65 years) v/s non-elderly (Ͻ 64 with acute ST elevation myocardial infarction (STEMI) who underwent Primary Percutaneous Coronary Intervention (PPCI).METHODS: Retrospective single Centre Observational study, analysing data 533 consecutive patients STEMI presented from April 1st 2008 to 31st Jan 2012 for PCI.Successful PCI was defined as residual stenosis Ͻ 20% and TIMI III flow culprit vessel.RESULTS: Of...
Abstract This study was designed to use some selected tumor markers (TMs) as screening tool discover new cancer cases, and these TMs diagnostic for early detection of cancer. The area is the River Nile State with an 122100 Km2 population 1026000 persons. national control program initiated in 1982 WHO help, updated 1990s based on guidelines. In 2010 National Cancer Registry established but still more efforts are needed register all cases such a poor country like Sudan. According Federal...