Fluconazole mucoadhesive buccal films were prepared using film forming polymers namely; hydroxypropyl methyl cellulose (HPMC), hydroxyethyl (HEC), chitosan, Eudragit and sodium alginate (SALG) either alone or in combination with bioadhesive polymers. The studied carboxymethyl (SCMC), Carbopol 974P, polycarbophil (AA-A). characterized by means of thickness, surface pH, swelling capacity, vitro adhesion, vivo residence time, drug release to determine the amount from selected formulae...

Fluconazole-entrapped multilamellar liposomes were prepared using the thin-film hydration method. The effects of cholesterol molar ratio, charge-inducing agents, and α-tocopherol acetate on encapsulation efficiency values in vitro drug release studied. Freeze-dried liposomal products with or without cryoprotectants. Results showed that incorporation stearylamine resulted an increased entrapment fluconazole, whereas dicetyl phosphate decreased efficiency. into fluconazole increase liposomes....

Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5–7 h), has narrow absorption window, is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, bioavailability (<60%). Moreover, GBP a freely water-soluble drug, thus it considered challenging candidate to be formulated as extended release dosage form. In this study, raft forming systems were investigated potential drug delivery system for prolonging gastric residence...

Milk thistle extract is a well-known hepatoprotectant with low bioavailability (20-50%). The objective of the present study to prepare and characterize silymarin phytosomes test hepatoprotective effect in CCl4 induced liver injury rats compared milk extract. Phytosomes were prepared using lecithin from soybeans egg yolk. examined scanning electron microscopy, transmission differential calorimetry, Fourier transform infrared spectroscopy proton nuclear magnetic resonance (H(1)NMR). loading...

Proniosomes offer a versatile vesicle drug delivery concept with potential for of drugs via transdermal route.To develop proniosomal gel using cremophor RH 40 as non-ionic surfactant containing the antihypertensive lacidipine so to avoid its extensive first pass metabolism and improve permeation through skin.Proniosomes 1% were prepared by coacervation phase separation method, characterized, optimized 2(3) full factorial design define optimum conditions produce proniosomes high entrapment...

Introduction: Betamethasone dipropionate (BD), a potent corticosteroid, and salicylic acid (SA), keratolytic agent, have been used in combination to treat scalp psoriasis; however, undesirable side effects associated with their prolonged topical use are inevitable. In this study, BD SA were loaded into cubosomes, nanoparticulate system outstanding biocompatibility, bio-adhesivity penetration power. Methods: Design of experiments (DOE) was utilized prepare thirteen different cubosomal...

Abstract The current study is regarding the development and characterization of Darifenacin-loaded self-assembled liquid crystal cubic nanoparticles (LCCN). An anhydrous approach was used for preparation these using a hydrotropic agent (propylene glycol), with minimal energy input. Upon dispersion in aqueous medium, system successfully transformed to cubosomal counterpart as depicted by transmission electron micrographs. A Box-Behnken design optimize formulation variables, namely A: amount...

Baclofen is a centrally acting skeletal muscle relaxant with short elimination half-life, which results in frequent daily dosing and subsequent poor patient compliance. The narrow absorption window of baclofen the upper gastrointestinal tract limits its formulation as extended release dosage forms. In this study, superporous hydrogel (SPH) systems, including conventional SPH, SPH composite hybrid (SPHH), were prepared aiming to increase residence at window. applicability different polymers,...

Solid self-nanoemulsifying (S-SNEDDS) asymmetrically coated osmotic tablets of the poorly water-soluble drug Vinpocetine (VNP) were designed. The aim was to control release VNP by technology taking advantage solubility and bioavailability-enhancing capacity S-SNEDDS. Liquid SNEDDS loaded with 2.5 mg composed Maisine™ 35-1, Transcutol® HP, Cremophor® EL adsorbed on solid carrier Aeroperl®. S-SNEDDS mixed tablet excipients (sodium chloride, Avicel®, HPMC-K4M, PVP-K30, Lubripharm®), then...

The active compounds present in Hypericum perforatum L. (Hypericaceae) include hyperforin, hypericins and flavonoids, which are assumed to be responsible for the activity of extract treatment wounds scars. study aimed incorporate H. standardized a known content phloroglucinols, naphthodianthrones polyphenolic into an effective transdermal drug delivery system capable entrapping both lipophilic hydrophilic constituents form niosomal gels wound treatment. An 80% ethanol (HE) was prepared on...

Bosentan is an endothelin receptor antagonist (ERA) prescribed for patients with pulmonary arterial hypertension (PAH). The oral delivery of bosentan possesses several drawbacks such as low bioavailability (about 50%), short duration action, frequent administration, hepatotoxicity and systemic hypotension. administration would circumvent the pre-systemic metabolism thus improving avoids adverse effects bosentan. However, action are major inhalation therapy. Thus, aim this work to explore...

In order to target celecoxib which is a COX2 inhibitor, with potentials in the prevention and treatment of colitis colon cancer, it was formulated as microparticles using solvent/evaporation method various pH-dependent Eudragit polymers. The in-vitro evaluation prepared showed spherical smooth morphology. encapsulation efficiency yield were high, indicating that used simple efficient at this scale. release study no acidic medium for 2 h followed by drug pH 6.8 case L100-55 L100 7.4 S100....